Molecular Triad RANK/ RANKL/ OPG in Mandible and Femur of Wistar Rats (Rattus norvegicus) With Type 2 Diabetes Mellitus

Hendrijantini, Nike; Rostiny, Rostiny; Kurdi, Abil; Ari, Muhammad Dimas Aditya; Sitalaksmi, Ratri Maya; Hapsari, Primarinda D.; Arief, Valentina Vida; Sati, Puthi Y.I.

doi:10.18639/rabm.2019.959614

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…Conversely, a decrease in OPG expression or an increase in RANKL expression can lead to pathological bone resorption characterized by an increase in the RANKL/OPG ratio. 16,18,32 This study found that the value of the RANKL/OPG ratio in the DM group was significantly lower than in the osteoporosis and control groups. This is probably caused by hyperglycemia which can cause a significant decrease in the RANKL/OPG ratio produced by osteoblasts.…”

Section: Discussionmentioning

confidence: 71%

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Bone Remodeling in Mandible of Wistar Rats with Diabetes Mellitus and Osteoporosis

et al. 2022

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Objectives This study aimed to determine some of bone molecular expressions and its possible bone remodeling pathway between diabetes mellitus (DM) and osteoporosis model in the mandibular bone of Wistar rats. Materials and Methods Twenty-seven female Wistar rats were divided randomly into control and treatment groups. Treatment groups were injected with streptozotocin intraperitoneally to induce DM (P1) and underwent bilateral ovariectomy to generate osteoporosis (P2). All groups were terminated after 12 weeks. Immunohistochemical and hematoxylin–eosin staining were performed to determine the expression of Runt-related transcription factor 2 (RUNX2), Osterix, vascular endothelial growth factor (VEGF), receptor activator of nuclear factor κB ligand (RANKL), osteoprotegerin (OPG), tartrate-resistant acid phosphatase (TRAP), and observed the osteoblast and osteoclast. Statistical analysis was performed using one-way analysis of variance. Results The lowest mean of RUNX2 and VEGF expression was found in the P2 group. The lowest mean of Osterix expression was found in the P1 group. Both P1 and P2 groups of osteoblast/osteoclast ratio were decreased. There were no significant differences in the expression of TRAP between all groups; however, increased expression of RANKL/OPG ratio was only found in the P2 group. Conclusion DM and osteoporosis induce changes in the bone remodeling pathway which are represented by a decrease in osteoblast biomarkers and an increase in osteoclast biomarkers.

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Section: Discussionmentioning

confidence: 71%

“…Conversely, a decrease in OPG expression or an increase in RANKL expression can lead to pathological bone resorption characterized by an increase in the RANKL/OPG ratio. 16 18 32 …”

Section: Discussionmentioning

confidence: 99%

Bone Remodeling in Mandible of Wistar Rats with Diabetes Mellitus and Osteoporosis

et al. 2022

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Human umbilical cord mesenchymal stem cells induction in peri-implantitis Rattus norvegicus accelerates and enhances osteogenesis activity and implant osseointegration

Hendrijantini

Kuntjoro

Agustono

et al. 2023

The Saudi Dental Journal

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Free Radicals and Actinobacteria as a Misexplored Goldmine of Antioxidant Compounds

Oliveira

Gusmão

Silva

et al. 2021

An. Acad. Bras. Ciênc.

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Free radicals are highly reactive unstable molecules, which can be synthesized in different ways, considered harmful and threatening to humans; these chemical species have free traffi c throughout the human body, interacting with biological molecules and human body organ tissues. The interaction between free radicals and biological molecules is the main factor for disease development or pre-existing disease symptoms aggravation. Antioxidants are chemical compounds able to donate electric charge to stabilize molecules such as free radicals. Recent studies have proved the benefi ts of antioxidants intake in health improvement. In this way, the search for natural sources of antioxidants has become an ascending trend. In this fi eld, the microbial sources are considered poorly explored compared to the numerous amount of other compounds obtained from them, especially from Actinobacteria. The searched literature about Actinobacteria highlights an important capacity of producing natural antioxidants; however, there is a lack of in vivo studies of these isolated compounds. In this review, we gathered information that supports our point of view that Actinobacteria is a truly renewable and superfi cially explored source of natural antioxidants. Furthermore, our purpose is also to point this limitation and stimulate more researches in this area.

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Molecular Triad RANK/ RANKL/ OPG in Mandible and Femur of Wistar Rats (Rattus norvegicus) With Type 2 Diabetes Mellitus

Cited by 3 publications

References 23 publications

Bone Remodeling in Mandible of Wistar Rats with Diabetes Mellitus and Osteoporosis

Bone Remodeling in Mandible of Wistar Rats with Diabetes Mellitus and Osteoporosis

Human umbilical cord mesenchymal stem cells induction in peri-implantitis Rattus norvegicus accelerates and enhances osteogenesis activity and implant osseointegration

Free Radicals and Actinobacteria as a Misexplored Goldmine of Antioxidant Compounds

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