Molecular Tuning Nanoarchitectonics for Molecular Recognition and Molecular Manipulation

Abstract

Although forefront research fields on molecular machineries and nano‐manipulation have been developed, their current achievements stay mostly in basic science and are far from practical usages in daily life. In this short review, interfacial nanoarchitectonics for structural and functional tuning of molecular machines, molecular receptors, and related molecular objects is conceptually overviewed towards possible applications. As their typical functions, regulation methods of molecular recognitions and the other functions in three mode, (i) fixed structure mode, (ii) switching mode, and (iii) tuning mode, are mainly discussed. The exemplified facts reveal great possibilities in molecular tuning at interfaces. The functional molecules immobilized at interfacial media can be manipulated in relation with macroscopic human motions, which would be one of the promising ways to use molecular‐level functions in life‐related activities.

Nanoarchitectonics for Analytical Science at Interfaces and with Supramolecular Nanostructures

“…Langmuir monolayer systems are also used for delicate tuning of molecular receptors for pressure-dependent chiral recognition 85 and discrimination between thymine and uracil derivatives. 86 This molecular tuning mode for molecular recognition 87 would be a novel methodology to select optimized (or the most desirable) receptor performance from numerous conformational candidates. It corresponds to the new generation molecular recognition mode after the first generation mode for one most stable complex and the second generation for switching receptors by external stimulation (Fig.…”

Progress in Molecular Nanoarchitectonics and Materials Nanoarchitectonics

“…Interfaces are nice playgrounds to produce various functional material properties [ 96 ]. Nanoarchitectonics at interfaces is advantageous for delicate tuning of functions [ 97 ]. For example, Ajayaghosh and co-workers delicately nanoarchitected the surface of conventional alumina materials to regenerate the bio-like wettability functions of rose petal and lotus leaf effects ( Figure 14 ) [ 98 ].…”

Nanoarchitectonics for Coordination Asymmetry and Related Chemistry

“…89 In addition, macroscopic mechanical deformation of the air-water interface enables us to manipulate conformation of receptor molecules to discriminate enantiomers of amino acids 90 and differentiate thymine and uracil derivatives. 91 Molecular manipulations at the air-water interface lead to receptor-tuning-type molecular recognition, 92 which is considered as the third generation of molecular recognition modes 93 next to one-stable state molecular recognition (the first generation) 94 and receptor-switching molecular recognition (the second generation). 95…”