2023
DOI: 10.1002/adma.202207053
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Molecular Tuning of a Benzene‐1,3,5‐Tricarboxamide Supramolecular Fibrous Hydrogel Enables Control over Viscoelasticity and Creates Tunable ECM‐Mimetic Hydrogels and Bioinks

Abstract: Traditional synthetic covalent hydrogels lack the native tissue dynamics and hierarchical fibrous structure found in the extracellular matrix (ECM). These dynamics and fibrous nanostructures are imperative in obtaining the correct cell/material interactions. Consequently, the challenge to engineer functional dynamics in a fibrous hydrogel and recapitulate native ECM properties remains a bottle‐neck to biomimetic hydrogel environments. Here, the molecular tuning of a supramolecular benzene‐1,3,5‐tricarboxamide … Show more

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Cited by 24 publications
(14 citation statements)
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“…In brief, the double hydrogel network, multi-level aggregation structure, and multiple non covalent interactions, including 𝜋-𝜋 stacking, electrostatic and various hydrogen bonding interactions, as well as dipole-dipole interactions of polymer clusters, all could provide efficient energy dissipation and recombination force, contributing to the self-healing and stretchable ability of the hydrogels. [54,55] Moreover, a significant amount of water was trapped within the 3D network of the hydrogel, enabling the mobility of TTpy molecules and supplying unsaturated hydrogen bonds, thereby facilitating rapid recombination of aggregations.…”
Section: Resultsmentioning
confidence: 99%
“…In brief, the double hydrogel network, multi-level aggregation structure, and multiple non covalent interactions, including 𝜋-𝜋 stacking, electrostatic and various hydrogen bonding interactions, as well as dipole-dipole interactions of polymer clusters, all could provide efficient energy dissipation and recombination force, contributing to the self-healing and stretchable ability of the hydrogels. [54,55] Moreover, a significant amount of water was trapped within the 3D network of the hydrogel, enabling the mobility of TTpy molecules and supplying unsaturated hydrogen bonds, thereby facilitating rapid recombination of aggregations.…”
Section: Resultsmentioning
confidence: 99%
“…Shear-thinning hydrogels have clearly been shown to increase cell viability during bioprinting, [61] and this property has been rationally designed using dynamic covalent bonds [62,63] and supramolecular hostguest interactions. [64][65][66] Recent reports showed the engineering of shear-thinning and 3D printing of self-assembled fibrous peptide amphiphiles, [67] peptide inks, [68,69] and BTAs; [70] however, designing a synthetic biomimetic bioink with 1D self-assembled fibers that possess both shear-thinning and remarkable toughness remains a formidable challenge.…”
Section: Introductionmentioning
confidence: 99%
“…With the development of hydrogel biomaterials, researchers have developed various types of viscoelastic and dynamic stiffness hydrogels to construct dynamic mechanical microenvironments. Viscoelastic hydrogels encompass physically crosslinked hydrogels (e.g., ion bonding [ 40 , 41 , 42 ], hydrogen bonding [ 43 , 44 , 45 ], hydrophobic interactions [ 46 , 47 , 48 ], and supramolecular interactions [ 49 , 50 , 51 ]) and dynamically covalently crosslinked hydrogels [ 52 , 53 , 54 ]. Dynamic stiffness hydrogels mainly include three types: dynamically softening hydrogels [ 55 ], dynamically stiffening hydrogels [ 56 ], and dynamically reversible stiffness hydrogels [ 57 , 58 ].…”
Section: Introductionmentioning
confidence: 99%