Molecular weight of polymers from methacryloyl lipids in bilayer membranes

Dorn, Klaus; Patton, Elizabeth; Klingbiel, R. T.; O’Brien, David F.; Ringsdorf, Helmut

doi:10.1002/marc.1983.030040802

Cited by 32 publications

(11 citation statements)

References 12 publications

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“…This peak may correspond to polymer formed in small particles through homogeneous nucleation or phase separation from the vesicle bilayer. In contrast, the greatest degree of polymerization reported for vesicles formed from polymerizable surfactants is approximately 500 monomer units . In our vesicles prepared with DVB the polymerized structure is certainly composed of a single cross-linked polymer molecule.…”

Section: Characterization Of Polymerized Vesiclesmentioning

confidence: 66%

Polymerization of Equilibrium Vesicles

1997

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Spontaneous vesicles form in aqueous solutions of mixtures of cationic and anionic surfactants. Here we report that vesicles are also found in systems containing a polymerizable monomer as a fourth component and that these vesicles can be polymerized with retention of the equilibrium structure. This is a convenient and versatile approach in which the vesicle architecture can be controlled by equilibrium surfactant selfassembly prior to polymerization, while the microstructure of the spherical polymer network can be controlled by the choice of monomer and degree of cross-linking.

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Section: Characterization Of Polymerized Vesiclesmentioning

confidence: 66%

Polymerization of Equilibrium Vesicles

1997

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“…The improved stability leads to a number of technological applications. The patents cover a wide range of the subject matter, for example: construction of stabilized vesicles [115, 1161, [115,118,120,1211, and antigen analysis [122]. A headgroup polymerizable lipid has been synthesized and studied with the goal of producing flexible membranes mimicking the skin ~421.…”

Section: Polymerizable Phospholipids and Technological Applicationsmentioning

confidence: 99%

Polymerizable phospholipids: a novel class of biomaterials

Singh

Schnur

1994

Polymers for Advanced Techs

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Polymerizable phospholipids are organic monomers that are able to self-assemble into membranes. This is quite similar to the self assembly of naturally occurring lipid membranes found in biological systems. The polymerizable lipids can then be polymerized to stabilize these membranes. These stabilized structures have a number of different morphologies which offer a variety of technically attractive features. This article reviews the chemical and physical properties of fhese materials in terms of their technological applications. DESIGNING A POLYMERIZABLE PHOSPHOLIPIDSince the first appearance of reports [9-121 describing the idea of polymerized vesicles for membrane stabilization, polymerizable phospholipids have attracted considerable attention from different disciplines. Consequently, the number of reports on the design, synthesis and application of novel polymerizable

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“…SEC has been used to characterize the molecular weight of lipid polymers. 16 Then, the glycerol backbone was removed from the lipid polymer by acid catalyzed transesterification,17 and the derived diacetylene acyl-chain polymer was also analyzed by SEC. Since determining molecular weights by SEC depends on calibration of the size exclusion column by polymer standards, and molecular weight standards do not exist for diacetylene polymers, SEC was used as a qualitative tool to compare the lipid and acyl-chain polymers from the different size vesicle samples. The reported molecular weights for the lipid and acyl-chain polymers reflect the molecular weights measured using polystyrene standards to calibrate the SEC column.…”

Section: Introductionmentioning

confidence: 99%

Effect of vesicle size on the polymerization of a diacetylene lipid

Peek¹,

Callahan²,

Namboodiri³

et al. 1994

Macromolecules

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The effect of vesicle size on the photopolymerization products of the polymerizable diacetylene lipid l,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine (DCe.gPC) has been examined using size exclusion chromatography (SEC) and mass spectrometry. Lipid polymers from 50-, 100-, 300-, and 600-nm vesicles have the same molecular weight range with a prominent polystyrene equivalent molecular weight peak between 1.6 x 10® and 2.2 x 104. The observed intensity of this peak increased as vesicle size was increased from 50through 300-nm diameter, but was decreased in 600-nm diameter vesicles. After acid catalyzed transesterification of the lipid polymers, the derived acyl chain polymers were examined by SEC. These polymers have a common prominent peak corresponding to a polystyrene equivalent molecular weight between 2.5 X 104 and 2.2 X 103. Size exclusion chromatography (SEC) and chemical ionization mass spectrometry revealed the presence of the polymerized acyl-chain dimer and trimer after methanolysis of the lipid polymer.

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Molecular weight of polymers from methacryloyl lipids in bilayer membranes

Cited by 32 publications

References 12 publications

Polymerization of Equilibrium Vesicles

Polymerization of Equilibrium Vesicles

Polymerizable phospholipids: a novel class of biomaterials

Effect of vesicle size on the polymerization of a diacetylene lipid

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