Molecular Whole-Body Cancer Staging Using Positron Emission Tomography: Consequences for Therapeutic Management and Metabolic Radiation Treatment Planning

Schmücking, Michael; Baüm, Richard; Griesinger, Frank; Presselt, N.; Bonnet, R.; Przetak, C; Niesen, A.; Leonhardi, J.; Lopatta, Eric; Herse, B.; Wendt, Thomas

doi:10.1007/978-3-642-59349-9_19

Cited by 40 publications

(23 citation statements)

References 15 publications

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“…The magnitude of this change in the primary tumor volume was higher than the magnitude of change in the lymph nodal volume. Similar results were seen in a study by Schmucking et al where about 92% patients experienced a decrease in tumor volume with the use of PETCT [17].…”

Section: Discussionsupporting

confidence: 90%

Impact of Integrating Pet-Ct in Radiotherapy Planning of Non-small Cell Carcinoma Lung: Dosimetric and Radiobiological Comparison

Kapoor¹,

Bansal²

2015

J Integr Oncol

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The integration of PET and CT scans allows the simultaneous use of biologic and anatomic imaging data for better delineating tumor and sparing normal critical structures. The aim of this study is to assess the impact on target volume delineation using CT vs. PETCT based plans, and to determine radiobiological effect on tumor and normal tissue by comparing Tumor control probability (TCP) & normal tissue complication probability (NTCP) of CT & PET-CT based plans. 15 patients of inoperable NSCLC planned for radical radiotherapy, underwent a planning CT scan of the thorax. Target volumes were contoured. Later PETCT images with the auto contoured MTV (Metabolic target volume) images, were fused with the planning CT images. Margins were similarly given to PETMTV for the generation of PET CTV and PET PTV. 3 Dimensional conformal radiotherapy (3DCRT) plans were made on the planning CT images and the planning PETCT images, and were compared dosimetrically and radio biologically. The study shows that the use of PETCT resulted in significant decrease in PETCT generated MTV versus GTV delineated on CT. Also, there was statistical significant decrease in the volume of the normal lung irradiated in terms of V40 and the MLD. TCP for PETCT based plans was significantly higher than that with CT based plans. Also, PETCT based planning resulted in a statistically significant decrease in the NTCP for lung and spinal cord. Therefore, the study concludes that incorporation of PETCT into radiotherapy planning of NSCLC is technically feasible and dosimetrically appealing strategy for patient treatment.

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Section: Discussionsupporting

confidence: 90%

Impact of Integrating Pet-Ct in Radiotherapy Planning of Non-small Cell Carcinoma Lung: Dosimetric and Radiobiological Comparison

Kapoor¹,

Bansal²

2015

J Integr Oncol

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“…Although pathologic complete response is mostly seen in patients who achieve major tumor shrinkage on CT, it is difficult to differentiate residual tumor from scar tissue in a residual mass on CT. 72 Several studies showed that FDG-PET could be very helpful in this condition. 38,[73][74][75] PET response was correlated with pathologic response in 5 studies, 38,40,68,74,75 and 5 studies also reported on the correlation of PET response and survival. 4,33,40,67,68 Multivariate stepwise analysis in the multicenter trial of Hoekstra et al 33 showed that PET identified prognostically different strata in patients considered responsive according to CT. 33 Unanimously, all studies on this subject (Table 3) show that the degree of residual tumor FDG uptake after induction therapy is, like tumor FDG uptake at diagnosis, a strong prognostic factor.…”

Section: Prognostic Value Of Fdg-pet After Induction Treatmentmentioning

confidence: 95%

Predictive and prognostic value of FDG‐PET in nonsmall‐cell lung cancer

Geus‐Oei

Heijden

Corstens

et al. 2007

Cancer

141

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“…In patients suffering from metastases of unknown primaries (CUP), the origin tumor was found in 24-53% [18]. Relevant changes of therapeutic management were reported in 18-52% of advanced NSCLC [5,12,18,21]. In patients with CUP, 44-63% had a different therapy after FDG PET [13,16].…”

Section: Discussionmentioning

confidence: 99%