Molecularly imprinted cryogel membranes for mitomycin C delivery

Öncel, Pınar; Çetin, Kemal; Topçu, Aykut Arif; Yavuz, Handan; Deni̇zli̇, Adil

doi:10.1080/09205063.2017.1282772

Cited by 31 publications

(15 citation statements)

References 41 publications

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“…Öncel et al also designed poly(2-hydroxyethyl methacrylate- N -methacryloyl- l -glutamic acid)-based cryogel for the delivery of mitomycin C. They carried out in vitro drug delivery studies to examine the effects of cross-linker ratio and template amount and observed that the cumulative release of mitomycin C was decreased with an increase in cross-linking agent ratio and higher template amount in cryogel structure. Cytotoxicity behavior of cryogel was investigated using mouse fibroblast cell line L929, and the results showed that L929 cell viability of cryogel was measured as 97.27 ± 3.57, which means it is not toxic [79].…”

Section: Composite Cryogels As Versatile Tools For Biomedical Applmentioning

confidence: 99%

Supermacroporous Composite Cryogels in Biomedical Applications

Saylan

Denizli

2019

Gels

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Supermacroporous gels, called cryogels, are unique scaffolds that can be prepared by polymerization of monomer solution under sub-zero temperatures. They are widely used in many applications and have significant potential biomaterials, especially for biomedical applications due to their inherent interconnected supermacroporous structures and easy formation of composite polymers in comparison to other porous polymer synthesis techniques. This review highlights the fundamentals of supermacroporous cryogels and composite cryogels, and then comprehensively summarizes recent studies in preparation, functionalization, and utilization with mechanical, biological and physicochemical features, according to the biomedical applications. Furthermore, conclusions and outlooks are discussed for the use of these promising and durable supermacroporous composite cryogels.

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Section: Composite Cryogels As Versatile Tools For Biomedical Applmentioning

confidence: 99%

Supermacroporous Composite Cryogels in Biomedical Applications

Saylan

Denizli

2019

Gels

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“…Materials generated by this technique present high chemical resistance, thermal stability, good mechanical properties and reusability [23]. Hence, considering the advantages of MI, many scientists have been using this technique to develop various advanced materials [24][25][26], such as membranes [27,28], beads [29], particles [30,31], micro-and nano-gels [32,33] or thin films [34,35], to be utilized as separation tools [36], catalysts [37] or sensors and biosensors [38] for metal recovery [39,40], drug delivery [41] and ternary mixture separation [42]. In this context, some authors have already reported the use of MI for developing TNT-MIPs using surface imprinting of silica nanoparticles [43] and nanotubes [44] or bulk imprinting of films [16,27].…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Sensitive Elements for 2,4,6-Trinitrotoluene Tested on Multi-Layered Sensors

et al. 2020

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In spite of technological progress, most of the current techniques for 2,4,6-trinitrotoluene (TNT) detection are time consuming due to laborious sensor preparation. Thereby, the aim of this work was to enlarge the knowledge for preparing sensitive elements for TNT with the aid of molecular imprinting; a known technique used to deliver biomimetic materials. The study first depicts the auto-assembly mechanism of (TNT) with functional diamino-silanes (i.e., N-(2-aminoethyl)-3-aminopropyl methyl dimethoxysilane), via “double” Meisenheimer complexes. This mechanism is being described herein for the first time and applied further to obtain molecularly imprinted polymer (MIP) films for TNT recognition. For testing the potential application of films as chemical sensor elements, typical rebinding assays of TNT in a liquid state and the rebinding of TNT in a vapor state, using multilayered sensor chips composed of quartz-chromium (Cr)-gold (Au)-titanium oxide (TiO2), were employed. Batch rebinding experiments have shown that thinner films were more efficient on retaining TNT molecules in the first five min, with a specificity of about 1.90. The quartz-Cr-Au-TiO2-MIP capacitive sensors, tested in vapor state, registered short response times (less than 25 s), low sensitivity to humidity and high specificity for TNT.

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“…They reported 7.4 optimal pH and 37 • C temperature for controlled release of curcumin. They obtained optimum values which were very compatible with in-body usage without any extreme release factors [50]. Çetin and Denizli have prepared 5-fluorouracil (5-FU) imprinted cryogel discs using a coordination complex between metal-chelate monomer MAH and 5-FU with the assistance of Cu(II) ion [51].…”

Section: Controlled Drug Deliverymentioning

confidence: 96%

Biomedical Applications of Polymeric Cryogels

et al. 2019

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The application of interconnected supermacroporous cryogels as support matrices for the purification, separation and immobilization of whole cells and different biological macromolecules has been well reported in literature. Cryogels have advantages over traditional gel carriers in the field of biochromatography and related biomedical applications. These matrices nearly mimic the three-dimensional structure of native tissue extracellular matrix. In addition, mechanical, osmotic and chemical stability of cryogels make them attractive polymeric materials for the construction of scaffolds in tissue engineering applications and in vitro cell culture, separation materials for many different processes such as immobilization of biomolecules, capturing of target molecules, and controlled drug delivery. The low mass transfer resistance of cryogel matrices makes them useful in chromatographic applications with the immobilization of different affinity ligands to these materials. Cryogels have been introduced as gel matrices prepared using partially frozen monomer or polymer solutions at temperature below zero. These materials can be produced with different shapes and are of interest in the therapeutic area. This review highlights the recent advances in cryogelation technologies by emphasizing their biomedical applications to supply an overview of their rising stars day to day.

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Molecularly imprinted cryogel membranes for mitomycin C delivery

Cited by 31 publications

References 41 publications

Supermacroporous Composite Cryogels in Biomedical Applications

Supermacroporous Composite Cryogels in Biomedical Applications

Biomimetic Sensitive Elements for 2,4,6-Trinitrotoluene Tested on Multi-Layered Sensors

Biomedical Applications of Polymeric Cryogels

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