Molecularly imprinted electrochemical sensor based on nickel nanoparticle-modified electrodes for phenobarbital determination

A novel strategy to improve the sensitivity of antibiotics determination based on bioelectrocatalysis at molecularly imprinted polymer film electrodes

“…Table 1 shows the performances of some examples of other MIP film systems for voltammetric determination of electro-inactive small molecules in comparison with the present system. Taking the LOD as an example, the KA-PPY MIP film system based on bioelectrocatalysis was superior to ordinary MIP film systems without using nanomaterials (Karimian et al, 2013;Liu et al, 2011;Wang et al, 2014), and it was comparable to or at the same order of magnitude as those with nanoparticles (Han et al, 2014;Xue et al, 2014;Yu et al, 2014). Some MIP systems with incorporated gold nanoparticles and/or carbon nanotubes demonstrated extremely high sensitivity (Rezaei et al, 2014a(Rezaei et al, , 2014b, possibly because the high effective surface area of electrodes led to the increase in the amount of recognition sites in the MIP films, and the excellent conductivity of the systems resulted in better electron transfer of the probe with the underlying electrodes (Irshad et al, 2013;Sharma et al, 2013).…”

“…To improve the sensitivity, nanomaterials have been introduced to MIP films in recent years (Guan et al, 2008;Han et al, 2014;Irshad et al, 2013;Xue et al, 2014;Yu et al, 2014). The introduction of nanoparticles not only increases the effective surface area and the corresponding amount of specific recognition sites in MIP films, but also improves the permeability of the films, leading to a higher CV response of the probe at the template-free MIP film electrodes and better detection sensitivity for the analyte.…”

Enzymes as Tools in MIP-Sensors

“…(ii) Binding of the target modulates the diffusive permeation of redox markers in a concentration-dependent manner. This effect has been frequently applied to characterize each step of MIP preparation for electro-inactive targets, such as melamine, methyl parathion, phenobarbital, caffeine, 17β-estradiol, acetylsalicylic acid, and warfarin [72][73][74][75][76]. In addition, this method is frequently applied to quantify the binding of the target analyte.…”

A highly sensitive sensor for simultaneous determination of ascorbic acid, dopamine and uric acid based on ultra-small Ni nanoparticles

“…Especially, nickel nanoparticles (Ni NPs) have been extensively used in electrode modification because of their inherent electrocatalytic activity for oxidation reactions, which is based on mediation redox reaction of Ni(OH) 2 /NiOOH on the electrode surface [25], as well as their good stability, mechanical strength, rapid electron transport and low cost [26,27]. Liu et al [28] developed a nonenzymatic glucose sensor based on the renewable Ni NPs-loaded carbon nanofiber paste (NiCFP) electrode.…”

“…Liu et al [28] developed a nonenzymatic glucose sensor based on the renewable Ni NPs-loaded carbon nanofiber paste (NiCFP) electrode. Yu et al [27] improved the sensitivity of sensors for Phenobarbital determination using uniform Ni NPs. Chen et al [29] developed a novel imprinted electrochemical sensor based on Ni NPs-graphene modified electrode for the determination of tetrabromobisphenol A. Zhang et al [30] prepared Ni NPs-carbon nanotubes hybrid to fabricate paste electrodes for electrochemical sensing of carbohydrates.…”