Molecularly imprinted membrane with innovative structure and high performance for chiral separation of amino acids

Gao, Baojiao; Li, Yanbin; Cui, Kunli

doi:10.1080/00914037.2017.1354198

Cited by 23 publications

(5 citation statements)

References 30 publications

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“…Gao et al 253 used a chloromethylated polysulfone membrane and applied an advanced surface imprinting technique for the separation of a racemic mixture of aspartic acid. By amine modification, an aminated polysulfone membrane was obtained.…”

Section: Membrane-based Chiral Separationmentioning

confidence: 99%

Semi-continuous and continuous processes for enantiomeric separation

2022

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Section: Membrane-based Chiral Separationmentioning

confidence: 99%

Semi-continuous and continuous processes for enantiomeric separation

2022

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“…As a result, the membrane not only exhibited excellent selectivity for 3,4‐dihydroxy‐D,L‐phenylalanine (D,L‐DOPA) with a chiral selectivity factor of over 2.0 but also showed remarkable flux. Gao et al 15 developed a chiral molecularly imprinted membrane using chloromethylated polysulfone (CMPSF) as the substrate membrane and L‐aspartic acid (L‐ASP) as the imprinted molecule. This membrane exhibited favorable chiral recognition of L‐ASP, achieving an enantiomeric excess percentage (ee%) of 82%.…”

Section: Introductionmentioning

confidence: 99%

Enantiomeric separation of tryptophan via novel chiral polyamide composite membrane

Peng,

Wei,

Peng

et al. 2024

Chirality

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The separation of chiral drugs continues to pose a significant challenge. However, in recent years, the emergence of membrane‐based chiral separation has shown promising effectiveness due to its environmentally friendly, energy‐efficient, and cost‐effective characteristics. In this study, we prepared chiral composite membrane via interfacial polymerization (IP), utilizing β‐cyclodextrin (β‐CD) and piperazine (PIP) as mixed monomers in the aqueous phase. The chiral separation process was facilitated by β‐CD, serving as a chiral selective agent. The resulting membrane were characterized using SEM, FT‐IR, and XPS. Subsequently, the chiral separation performance of the membrane for DL‐tryptophan (Trp) was investigated. Lastly, the water flux, dye rejection, and stability of the membrane were also examined. The results showed that the optimized chiral PIP0.5β‐CD0.5 membrane achieved an enantiomeric excess percentage (ee%) of 43.0% for D‐Trp, with a solute flux of 66.18 nmol·cm−2·h−1, and maintained a good chiral separation stability. Additionally, the membrane demonstrated positive performance in the selective separation of mixed dyes, allowing for steady operation over a long period of time. This study offers fresh insights into membrane‐based chiral separations.

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“…When the mixed solution penetrates into the MIM, the target molecule will be captured by the recognition site according to the specific interaction, thereby promoting or hindering the delivery of the target molecule. Hence, the selective separation of chiral pesticides can be achieved. − …”

Section: Introductionmentioning

confidence: 99%

Highly Improved Chiral-Selective Resolution in Pillar[5]arene-Functionalized Molecularly Imprinted Membranes

Wang

Yang

et al. 2022

ACS Appl. Polym. Mater.

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It is a challenging task to achieve the effective separation of chiral compounds under simple and rapid conditions. In order to solve this problem, this study used the molecularly imprinted membrane (MIM) technology developed on the basis of biological semi-permeable membranes, using S-triadimefon as the template molecule, and successfully prepared MIMs by photo-initiated polymerization. By adding macrocyclic molecular 1,4-bis(allyloxy)pillar[5]arene as a functional monomers, the effectiveness of the chiral recognition sites of the target molecules is improved, thereby improving the chiral selectivity of the MIM and optimizing the molar ratio of template molecules, monomers, and cross-linkers. On this basis, the separation effect of non-MIM (NIM), single-monomer MIM (MIM-I), and two-monomer MIM (MIM-II) on triadimefon enantiomers was investigated. It was found that the enantiomer excess (e. e.) % value of MIM-I is larger than that of NIM, but the value of MIM-I is still very low. When pillar[5]arene, a macrocyclic molecule was added as the second monomer, its e. e. % increased from 27.4 to 84.8%.

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Molecularly imprinted membrane with innovative structure and high performance for chiral separation of amino acids

Cited by 23 publications

References 30 publications

Semi-continuous and continuous processes for enantiomeric separation

Semi-continuous and continuous processes for enantiomeric separation

Enantiomeric separation of tryptophan via novel chiral polyamide composite membrane

Highly Improved Chiral-Selective Resolution in Pillar[5]arene-Functionalized Molecularly Imprinted Membranes

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