Molecularly Imprinted Micro-Solid-Phase Extraction for the Selective Determination of Phenolic Compounds in Environmental Water Samples with High Performance Liquid Chromatraphy

Abstract

ABSTRACT2,4,6-trichlorophenol molecularly imprinted suspension polymer has been prepared and applied to the molecularly imprinted micro-solid-phase extraction procedure for selective preconcentration of phenolic compounds from environmental water samples. The influence of functional monomer, cross-linker, polymerization condition, porogen, and the ratio of template molecule and functional monomer to cross-linker on the size of the obtained particles were investigated. It was found that methyacrylic acid as functional monomer, divinylbenzene as cross-linker, the molar ratio of template molecule and functional monomer to cross-linker was 1:4:20, the amount of AIBN was 100 mg, ultraviolet radiation at 365 nm were the optimal conditions, and at these conditions, the polymers had the best adsorption efficiency and had the monodispersity of 2 -3 μm microsphere particles. The characteristics of the MIMSPE method were valid by high performance liquid chromatography. This MIMSPE-HPLC method has been successfully applied to the direct preconcentration and determination of phenolic compounds (phenol, 4-chlorophenol, 2,4-dichlorophenol, 2,4,6-trichlorophenol, pentachlorophenol) in environmental water samples.

A Review: Using Multiple Templates for Molecular Imprinted Polymer: Is It Good?

“…SPE itself has been applied in the field of extraction and separation for a long time [ 95 , 96 ]. However, general absorbents cannot absorb the analyte optimally due to the presence of a complex matrix mixed with the analyte [ 97 , 98 ]. Therefore, we need absorbents that have high selectivity and are stable, reusable, low cost, and time efficient [ 98 , 99 , 100 ].…”

“…However, general absorbents cannot absorb the analyte optimally due to the presence of a complex matrix mixed with the analyte [ 97 , 98 ]. Therefore, we need absorbents that have high selectivity and are stable, reusable, low cost, and time efficient [ 98 , 99 , 100 ]. As previously explained, MT-MIP has these advantages.…”

A highly sensitive monoclonal antibody−based paper sensor for simultaneously detecting valnemulin and tiamulin in porcine liver

“…Many conventional analytical methods have been established to supervise the use of PLEs, such as high‐performance liquid chromatography (Feng, Yang, Xu, Zhang, & Liu, 2013; Guo et al., 2011), liquid chromatographic–tandem mass spectrometry (Patyra, Nebot, Gavilán, Cepeda, & Kwiatek, 2018) and ultra‐high‐performance liquid chromatography–tandem mass spectrometry (Gajda, Nowacka‐Kozak, Gbylik‐Sikorska, & Posyniak, 2019; Li et al., 2016; Yang et al., 2014). These technical tools possess excellent accuracy, sensitivity, and reproducibility (Shi, Yang, He, & Fu, 2019); however, they are expensive, time‐consuming, and require professional training to use, making them not suitable for on‐site rapid detection (Qin et al., 2019).…”