Molecularly Imprinted Microspheres for Bisphenol A Prepared Using a Microfluidic Device

Takano, Eri; Tanaka, Fujimaru; Ooya, Tooru; Takeuchi, Toshio

doi:10.2116/analsci.28.457

Cited by 11 publications

(5 citation statements)

References 23 publications

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“…Another O/W attempt to create spherical MIP particles was reported by Takano et al [58]. A Y-junction microfluidic device was prepared for the affinity-based solid phase extraction of Bisphenol A (BPA), which acts like an endocrine disruptor by interacting with estrogen receptors.…”

Section: Droplet-based Microfluidics For the Preparation Of Mips And ...mentioning

confidence: 99%

Molecularly Imprinted Polymeric Particles Created Using Droplet-Based Microfluidics: Preparation and Applications

Orbay

Sanyal

2023

Micromachines

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Recent years have witnessed increased attention to the use of droplet-based microfluidics as a tool for the fabrication of microparticles due to this method’s ability to exploit fluid mechanics to create materials with a narrow range of sizes. In addition, this approach offers a controllable way to configure the composition of the resulting micro/nanomaterials. To date, molecularly imprinted polymers (MIPs) in particle form have been prepared using various polymerization methods for several applications in biology and chemistry. However, the traditional approach, that is, the production of microparticles through grinding and sieving, generally leads to poor control over particle size and distribution. Droplet-based microfluidics offers an attractive alternative for the fabrication of molecularly imprinted microparticles. This mini-review aims to present recent examples highlighting the application of droplet-based microfluidics to fabricate molecularly imprinted polymeric particles for applications in the chemical and biomedical sciences.

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Section: Droplet-based Microfluidics For the Preparation Of Mips And ...mentioning

confidence: 99%

Molecularly Imprinted Polymeric Particles Created Using Droplet-Based Microfluidics: Preparation and Applications

Orbay

Sanyal

2023

Micromachines

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“…BPA-MIP particles were also prepared using a similar microfluidic device with a width of 630 μm and a depth of 330 μm [91]. A dispersed phase of a dichloromethane solution containing styrene, divinylbenzene, and 2,2'-azobis(2,4-dimethylvaleronitrile) was pumped at 10 μL min -1 , and a continuous phase containing 5.0 wt % poly(vinyl alcohol) was pumped at various flow rates between 300 and 2200 μL min -1 .…”

Section: Preparation Of Mips Using Microfluidicsmentioning

confidence: 99%

Molecularly Imprinted Tailor-Made Functional Polymer Receptors for Highly Sensitive and Selective Separation and Detection of Target Molecules

et al. 2016

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Molecularly imprinted polymers (MIPs) are functional materials capable of molecular recognition and other biorelevant functions and can be prepared with ease in a tailor-made fashion by copolymerization in the presence of a crosslinker and a template molecule (the target molecule or its analog) conjugated with a functional monomer(s). These robust and affordable synthetic polymer receptors are highly accepted as favorable alternatives to biomacromolecules such as antibodies and enzymes. This article provides a critical review of the present state of MIPs to establish perspectives on this technique via a survey of early to contemporary work, mainly conducted by the authors, covering new principles and methodology to generate MIPs. These include the design and synthesis of new functional monomers and crosslinkers to develop and/or introduce new functionalities, new polymerization methods to improve the imprint effect, and highly sensitive MIP-based assays and sensors.

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“…[10][11][12] The synthesis of molecular imprinting polymer (MIP) is based on the copolymerization of the template and functional monomer through the covalent/non-covalent interactions with excess cross linkers. After polymerization, they have special cavities with corresponding steric and chemical memory with the removal of the template.…”

Section: Introductionmentioning

confidence: 99%

Development and Applications of Quantum Dot-based Molecularly Imprinted Polymer Composites for Optosensing of Carbofuran in Water

et al. 2017

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23Chen et al. fabricated and successfully utilized MIP-coated QDs for cyphenothrin detection in river water. 24 However, in these methods the value of fluorescence they collected were all by fluorescence spectrophotometry, which only supplies the fluorescence information of samples illuminated by the light source of the instrument. In addition, the polymers of each sample could not keep the same dispersion state, which resulted in inaccuracies in the detected fluorescence data. So a more effective method was needed.As a new analytical technique, cytometric bead array (CBA) has achieved real-time and rapid detection of targeted 2017 © The Japan Society for Analytical Chemistry † To whom correspondence should be addressed. In this paper, quantum dot (QD)-based molecularly imprinted polymer (MIP) was fabricated and successfully utilized as a fluorescent probe for highly selective and sensitive detection of carbofuran in water samples. The MIPs were synthesized followed by a multi-step swelling and polymerization method, and then labeled with CdSe/ZnS QDs via gradual solvent evaporation. Then the prepared QDs-MIP microspheres were introduced to flow cytometry by virtue of their good dispersibility in water, and fast adsorption and desorption. Under optimized conditions, the fluorescence intensity of QDs-MIP decreased linearly with the increasing of carbofuran in the concentration range of 1 -20 μg L -1 (R 2 > 0.99) and it can detect down to 0.2 μg L -1 of carbofuran. This method was simple, selective and applied successfully to the optosensing of trace carbofuran in water samples with good recoveries ranging from 94.1 ± 3.7 to 98.4 ± 4.5%.

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Molecularly Imprinted Microspheres for Bisphenol A Prepared Using a Microfluidic Device

Cited by 11 publications

References 23 publications

Molecularly Imprinted Polymeric Particles Created Using Droplet-Based Microfluidics: Preparation and Applications

Molecularly Imprinted Polymeric Particles Created Using Droplet-Based Microfluidics: Preparation and Applications

Molecularly Imprinted Tailor-Made Functional Polymer Receptors for Highly Sensitive and Selective Separation and Detection of Target Molecules

Development and Applications of Quantum Dot-based Molecularly Imprinted Polymer Composites for Optosensing of Carbofuran in Water

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