Molecularly Imprinted Nanomaterial‐Based Highly Sensitive and Selective Medical Devices

Prasad, Bhim Bali; Tiwari, Mahavir Prasad

doi:10.1002/9781118523025.ch12

Cited by 5 publications

(3 citation statements)

References 212 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Molecularly imprinted polymers (MIPs) able to mimic natural receptors, offer tailored selectivity towards target molecules and better chemical and thermal stability in a simple and cost-effective manner [ 1 ]. MIPs have been widely employed for the concentration, separation and analysis of various bioactives, either as stationary phases in chromatography and capillary electrophoresis [ 2 , 3 , 4 , 5 , 6 ], or as recognition elements in chemo- and biosensing [ 7 , 8 , 9 ]. Within the extensive body of literature, a considerable part focuses on the use of these polymers for chiral analysis [ 2 , 7 , 10 , 11 , 12 , 13 ] in various pharmaceutical, biomedical or environmental applications.…”

Section: Introductionmentioning

confidence: 99%

Improved Enantioselectivity for Atenolol Employing Pivot Based Molecular Imprinting

et al. 2018

View full text Add to dashboard Cite

In the last few decades, molecular imprinting technology went through a spectacular evolution becoming a well-established tool for the synthesis of highly selective biomimetic molecular recognition platforms. Nevertheless, there is still room for advancement in the molecular imprinting of highly polar chiral compounds. The aim of the present work was to investigate the favorable kosmotropic effect of a ternary complex involving a polar chiral template (eutomer of atenolol) and a functional monomer, bridged by a central metal ion through well-defined, spatially directional coordinate bonds. The efficiency of the chiral molecular recognition was systematically assessed on polymers obtained both by non-covalent and metal-mediated molecular imprinting. The influence on the chromatographic retention and enantioselectivity of different experimental variables (functional monomers, cross-linkers, chaotropic agents, metal ions, porogenic systems, etc.) were studied on both slurry packed and monolithic HPLC columns. Deliberate changes in the imprinting and rebinding (chromatographic) processes, along with additional thermodynamic studies shed light on the particularities of the molecular recognition mechanism. The best performing polymer in terms of enantioselectivity (α = 1.60) was achieved using 4-vinyl pyridine as functional monomer and secondary ligand for the Co(II)-mediated imprinting of S-atenolol in the presence of EDMA as cross-linker in a porogenic mixture of [BMIM][BF4]:DMF:DMSO = 10:1:5, v/v/v.

show abstract

Section: Introductionmentioning

confidence: 99%

Improved Enantioselectivity for Atenolol Employing Pivot Based Molecular Imprinting

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Their non-invasive nature and remote patient monitoring reduce hospital visits and throwaway medical supplies, further supporting sustainability goals. [2][3][4] These technologies have been applied to innovate and develop low-power sensor modes that can enable devices to function for long periods without compromising their performance. These modes typically use innovative algorithms and energy-efficient components to substantially minimize sensor power consumption, while increasing the battery life and therefore decreasing the battery replacement requirements.…”

Section: Sensors and Diagnosticsmentioning

confidence: 99%

“…Intelligent point-of-care (PoC) devices are crucial for managing healthcare and making decisions in real-time. 1,2 The internet of things (IoT) and associated health applications are increasing the commercial value of sensors. Biosensor nanotechnology is used to design wearable electronic devices with advanced materials.…”

Section: Introductionmentioning

confidence: 99%

Emergence of integrated biosensing-enabled digital healthcare devices

Mishra,

Singh,

Chauhan

et al. 2024

Sens. Diagn.

View full text Add to dashboard Cite

show abstract

Recent advances in capillary electrochromatography using molecularly imprinted polymers

2014

View full text Add to dashboard Cite

There is an increased and continuous need for developing new methods for the separation and quantification of an increasing number of analytes in the environmental, pharmaceutical, pharmacological, and toxicological sciences. CEC is still withholding its popularity, representing a viable alternative to the more conventional techniques (HPLC, GC) due to the numerous advantages, such as, low sample/reagent volumes, high separation efficiencies, hybrid separation principle, etc. One particular promising direction in CEC is the use of molecularly imprinted polymers (MIPs) as stationary phases. They are usually immobilized in the capillary column as a continuous polymeric monolith or as a thin polymer coating attached to the capillary's inner wall. Another emerging trend is the use of MIPs in the form of nanoparticles as a pseudostationary phase. This review discusses the recent developments (2011-2013) in finding the optimal polymerization mixture and the suitable MIP format that should be employed in CEC separations. The most important applications of MIPs in CEC technique are also highlighted.

show abstract

Molecularly Imprinted Nanomaterial‐Based Highly Sensitive and Selective Medical Devices

Cited by 5 publications

References 212 publications

Improved Enantioselectivity for Atenolol Employing Pivot Based Molecular Imprinting

Improved Enantioselectivity for Atenolol Employing Pivot Based Molecular Imprinting

Emergence of integrated biosensing-enabled digital healthcare devices

Recent advances in capillary electrochromatography using molecularly imprinted polymers

Contact Info

Product

Resources

About