Molecularly imprinted polymer based diffusive gradients in thin‐films for in situ selective sampling and determination of ciprofloxacin

Li, Yanan; Chen, Hong; Zhu, Yu; Zhang, Tingting; Gu, Jie; Xu, Yongxia; Lǐ, Jiànróng

doi:10.1002/jssc.201800649

Cited by 10 publications

(3 citation statements)

References 30 publications

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“…The highly polar aprotic solvent (ACN) is suitable for preparing of CIP imprinted polymers. 19,24 In contrast, the polar protic solvent (methanol) reduces the imprinted polymer selectivity due to their competitive interaction with MAA via hydrogen bond. 19 Moreover, the MIPs synthesized in highly polar solvents have small particles (<2 mm) for SPE applications.…”

Section: Synthesis Of Imprinted Polymersmentioning

confidence: 99%

Co-precipitation polymerization of dual functional monomers and polystyrene-co-divinylbenzene for ciprofloxacin imprinted polymer preparation

et al. 2021

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Section: Synthesis Of Imprinted Polymersmentioning

confidence: 99%

Co-precipitation polymerization of dual functional monomers and polystyrene-co-divinylbenzene for ciprofloxacin imprinted polymer preparation

et al. 2021

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“…DGTs have been successfully applied to measure trace components in situ in aquatic environments, especially to monitor trace contaminants with high water solubility. − Since Chen et al applied DGT to detect the sulfonamide antibiotic in water in 2012, DGT has been gradually developed for the detection of various organic substances in aquatic environment. To date, DGT has been applied to detect pharmaceuticals, , antibiotics, estrogen, anionic pesticides, illicit drugs, , and organophosphate esters . Guo et al confirmed that DGTs can be used for in situ monitoring of several illicit drugs, including METH, in waste waters and rivers .…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Accumulation of Methamphetamine and Its Metabolite Amphetamine by Diffusive Gradients in Thin Films to Estimate Their Bioavailability in Zebrafish

Yin

Guo

et al. 2019

Environ. Sci. Technol. Lett.

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In this study, we evaluated the application of the diffusive gradient in the thin films (DGT) technique to predict the bioavailability of methamphetamine (METH) and its metabolite, amphetamine (AMP), in zebrafish (Danio rerio). We simultaneously exposed zebrafish and DGT devices to water spiked with different concentrations of METH. Subsequently, METH and its major metabolite, AMP, were quantified in DGTs and in zebrafish in vivo, the latter of which tended to bioaccumulate and biotransform METH to AMP. After a two-week duration of METH exposure, concentrations were up to 4.49 ± 0.17, 6.42 ± 0.06, and 132 ± 0.48 ng/g wet weight for METH and 4.25 ± 0.62, 8.46 ± 0.58, and 419 ± 45.0 ng/g wet weight for AMP in zebrafish when exposed to 0.01, 1.00, and 100.00 μg/L of METH solution, respectively. Although the in vivo bioaccumulation and biotransformation of METH in zebrafish are likely complex, we found a strong positive correlation (R 2 = 0.97–1.00, p < 0.001) between the mass of METH uptake by the DGT and the METH concentrations in vivo in zebrafish. Similarly, there was also a significant correlation (R 2 = 0.95, p < 0.001) between the AMP concentration in zebrafish and the mass of AMP uptake by the DGT at a METH exposure concentration of 1.00 μg/L. The correlation in the other two exposure concentrations was not strong, probably due to the fact that AMP accumulated in fish did not increase in a concentration-dependent manner. Taken together, these findings suggest that the DGT may act as a useful tool for estimating the bioavailability of METH and its metabolite, AMP, in aquatic organisms.

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“…In contrast, research and development of DGT for organic chemicals only started in 2012, but it has already attracted considerable interest and is developing rapidly . To date, sampler development and testing of 136 organic compounds has been reported in the literature (a few from personal communication), with more being conducted. − Compound classes include pharmaceuticals and personal care products, illicit drugs, endocrine-disrupting chemicals and pesticides, etc. Table S1 summarizes these publications.…”

mentioning

confidence: 99%

Investigating Potential Limitations of Current Diffusive Gradients in Thin Films (DGT) Samplers for Measuring Organic Chemicals

et al. 2019

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The diffusive gradients in thin films (DGT) passive sampler has emerged as a 21 powerful tool for measuring in situ concentrations of organic contaminants in waters with 22 appropriate spatial and temporal resolution at low cost. This study addresses the property range of compounds which can be routinely sampled with the present design of DGT device.24 Sorption experiments and DGT deployment with 9 model chemicals [organophosphate esters 25 with a wide range of log K OW (0.8-9.5), molecular weight (182-435 Da)] and different 26 functional groups showed compounds with high hydrophobicity and aromatic rings are prone 27 to retention on membrane filters, which slows the supply of chemical to the binding resin of 28 the sampler. The current DGT sampler (PTFE membrane filter, agarose gel diffusion layer 29 and HLB binding layer) is potentially reliable for measuring hydrophilic [log K OW (0.8-2.6)]30 and non-aromatic-ring chemicals. For compounds of higher values of K OW or with aromatic 31 rings, knowledge of the lag phase is necessary to optimize sampling times to avoid biasing 32 subsequent laboratory analyses. A standard procedure is used to measure lag times (from 33 minutes to days), by exposing a series of DGT samplers in waters until linear mass 34 accumulation in samplers is achieved. We discuss how monitoring of a wide array of organic 35 contaminants across classes should be possible in future, with a range of validated new DGT 36 devices, optimized for the choice of membrane filter, diffusive material and binding resin.

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Molecularly imprinted polymer based diffusive gradients in thin‐films for in situ selective sampling and determination of ciprofloxacin

Cited by 10 publications

References 30 publications

Co-precipitation polymerization of dual functional monomers and polystyrene-co-divinylbenzene for ciprofloxacin imprinted polymer preparation

Co-precipitation polymerization of dual functional monomers and polystyrene-co-divinylbenzene for ciprofloxacin imprinted polymer preparation

Biomimetic Accumulation of Methamphetamine and Its Metabolite Amphetamine by Diffusive Gradients in Thin Films to Estimate Their Bioavailability in Zebrafish

Investigating Potential Limitations of Current Diffusive Gradients in Thin Films (DGT) Samplers for Measuring Organic Chemicals

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