Molecularly imprinted polymer based electrochemical detection of L-cysteine at carbon paste electrode

Aswini, K.K.; Mohan, A. M. Vinu; Biju, V.M.

doi:10.1016/j.msec.2014.01.020

Cited by 51 publications

(13 citation statements)

References 32 publications

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“…This suggests that the reduction peak is associated with the interaction of the carboxylic group of MAA with the phosphate group. Although this reduction peak has not been previously reported for similar CPEs modified with MAA-MIP, [23][24][25][26][27][28][29][30] none of these systems employed a phosphate molecule as the template for the MIP construction or were used as sensors for phosphate. The addition of 0.1 mmol L -1 H 3 PO 4 to the supporting electrolyte solution increased the cathodic current at the reduction peak of +0.5 V for the modified electrodes.…”

Section: B Electrochemical Behavior Of Unmodified and Modified Cpesmentioning

confidence: 60%

Low-Range Detection of the Phosphate Group by a Molecularly Imprinted Polymer-Modified Carbon Paste Electrode

et al. 2015

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A series of size-selective polymeric sensors for the phosphate group was designed and synthesized using the molecularly imprinted polymer (MIP) technique based on the non-covalent interaction of the template dipentyl phosphate (DPP) with the functional monomer methacrylic acid (MAA). Very low-range specific electrochemical detection of phosphate molecules was performed by square wave voltammetry (SWV) with a modified carbon paste electrode (CPE). Calibration curves were obtained within the linear range of 20 to 300 nmol L -1 for all modified CPEs, with the lowest detection limit (DL) determined as 8.82 nmol L -1 . Potential inorganic interferents, such as carbonate, nitrate and sulfate ions, were investigated and no signal disturbance was observed for relative concentrations 100 times higher than the phosphate concentration. Furthermore, the modified electrodes also showed good selectivity for phosphate molecules containing alkyl chains with up to five carbon atoms. The selectivity study confirmed that imprinted sites were successfully synthesized and only structures that are the same size or smaller than those of the template molecule are selected by maximizing intermolecular interactions at the MIP binding site. Moreover, the sensors presented good stability, maintaining the same degree of selectivity for several months. These sensors were also applied in the determination of phosphate in a cola soft drink.Index Terms-Carbon paste selective electrode, phosphate, molecularly imprinted polymer.

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Section: B Electrochemical Behavior Of Unmodified and Modified Cpesmentioning

confidence: 60%

Low-Range Detection of the Phosphate Group by a Molecularly Imprinted Polymer-Modified Carbon Paste Electrode

et al. 2015

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“…The surface was regenerated after each set of electrochemical experiments by removing a thin layer of paste from the surface. The modified carbon paste electrode (MIP‐CPE) was prepared by mixing MIP with graphite powder by replacing it in specified percentages (1 %, 5 %, 10 %, 15 % and 20 %) , and mixing till became homogenous for almost ten minutes, and then the paraffin oil was added and the components were mixed together for another ten minutes. The NIP modified CPE (NIP‐CPE) was prepared by following the same procedure at the optimum composition obtained for (MIP‐CPE).…”

Section: Methodsmentioning

confidence: 99%

Voltammetric Determination of Valaciclovir Using a Molecularly Imprinted Polymer Modified Carbon Paste Electrode

et al. 2017

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A molecularly imprinted polymer (MIP) was rationally synthesized with the aid of computer based studies. The computational studies were used to screen for the most suitable template to functional monomer molar ratio. Two functional monomers were involved in the study (methacrylic acid and 4‐vinylpyridine). Four MIP ratios were synthesized in accordance with the results of the computational studies and their performance was evaluated using equilibrium rebinding assays. The MIP with the best performance was used as an additive in carbon paste electrodes for the voltammetric determination of valaciclovir (VCV). Following the optimization of voltammetric parameters, a linear response was obtained in the range of 1.0x10−6–7.0x10−4 M with a limit of detection at 4.45x10−7 M. The MIP modified carbon paste electrode was successfully applied for the determination of VCV in pure solutions and dosage form.

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“…First comparing the adsorption capacity values for MIP 5 and MIP 6 , it should be noted that MIP 6 had higher adsorption capacity and IF than MIP 5 . Therefore we used AM as functional monomer to prepare MIPs.…”

Section: Application For Metolcarb Mips In the Four Algorithmsmentioning

confidence: 99%

Validation and application of modeling algorithms for the design of molecularly imprinted polymers

Liu

Zhang

et al. 2014

J of Separation Science

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In the study, four different semiempirical algorithms, modified neglect of diatomic overlap, a reparameterization of Austin Model 1, complete neglect of differential overlap and typed neglect of differential overlap, have been applied for the energy optimization of template, monomer, and template-monomer complexes of imprinted polymers. For phosmet-, estrone-, and metolcarb-imprinted polymers, the binding energies of template-monomer complexes were calculated and the docking configures were assessed in different molar ratio of template/monomer. It was found that two algorithms were not suitable for calculating the binding energy in template-monomers complex system. For the other algorithms, the obtained optimum molar ratio of template and monomers were consistent with the experimental results. Therefore, two algorithms have been selected and applied for the preparation of enrofloxacin-imprinted polymers. Meanwhile using a different molar ratio of template and monomer, we prepared imprinted polymers and nonimprinted polymers, and evaluated the adsorption to template. It was verified that the experimental results were in good agreement with the modeling results. As a result, the semiempirical algorithm had certain feasibility in designing the preparation of imprinted polymers.

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Molecularly imprinted polymer based electrochemical detection of L-cysteine at carbon paste electrode

Cited by 51 publications

References 32 publications

Low-Range Detection of the Phosphate Group by a Molecularly Imprinted Polymer-Modified Carbon Paste Electrode

Low-Range Detection of the Phosphate Group by a Molecularly Imprinted Polymer-Modified Carbon Paste Electrode

Voltammetric Determination of Valaciclovir Using a Molecularly Imprinted Polymer Modified Carbon Paste Electrode

Validation and application of modeling algorithms for the design of molecularly imprinted polymers

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