Molecularly Imprinted Polymer‐Based Smart Prodrug Delivery System for Specific Targeting, Prolonged Retention, and Tumor Microenvironment‐Triggered Release

Gu, Zikuan; Dong, Yueru; Xu, Shuxin; Wang, Lisheng; Liu, Zhen

doi:10.1002/anie.202012956

Cited by 112 publications

(58 citation statements)

References 59 publications

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“…Thus, MIP-NPs are ideal for functional interactions with biomolecules, opening applications in molecular diagnosis both at the cell and tissue levels, 8 for in vivo removal of toxins, 5 for interfering with metastatic proliferation, 9 , 10 for protein refolding, 11 or for acting as targeted prodrugs in contrasting the growth of cancer cells. 12 …”

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Silk Fibroin Nanoparticles

Bossi

Bucciarelli

Maniglio

2021

ACS Appl. Mater. Interfaces

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Nanosized biomimetics prepared by the strategy of molecular imprinting, that is, the stamping of recognition sites by means of a template-assisted synthesis, are demonstrating potential as plastic antibodies in medicine, proving effective for cell imaging and targeted therapies. Most molecularly imprinted nanoparticles (MIP-NPs) are currently made of soft matter, such as polyacrylamide and derivatives. Yet, MIP-NPs biocompatibility is crucial for their effective translation into clinical uses. Here, we propose the original idea to synthesize fully biocompatible molecularly imprinted nanoparticles starting from the natural polymer silk fibroin (MIP SF-NPs), which is nontoxic and highly biocompatible. The conditions to produce MIP SF-NPs of different sizes ( d mean ∼ 50 nm; d mean ∼ 100 nm) were set using the response surface method. The stamping of a single, high affinity ( K D = 57 × 10 –9 M), and selective recognition site per silk fibroin nanoparticle was demonstrated, together with the confirmation of nontoxicity. Additionally, MIP SF-NPs were used to decorate silk microfibers and silk nanofibers, providing a general means to add entailed biofunctionalities to materials.

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Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Silk Fibroin Nanoparticles

Bossi

Bucciarelli

Maniglio

2021

ACS Appl. Mater. Interfaces

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“…The controlled release of Flu is significant for alleviating its side effects. [ 15 ] As shown in Figure 1h, esterase promoted the release of Flu significantly. The results indicated that the rapid release of Flu only occurred in the cytoplasm.…”

Section: Resultsmentioning

confidence: 92%

Traceable Nano‐Biohybrid Complexes by One‐Step Synthesis as CRISPR‐Chem Vectors for Neurodegenerative Diseases Synergistic Treatment

et al. 2021

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Abnormal protein aggregations are essential pathological features of neurodegenerative diseases. Eliminating while inhibiting the regeneration of these protein aggregates is considered an effective treatment strategy. Herein, the CRISPR/Cas9 gene‐editing tool is employed to inhibit the regeneration of disease‐related proteins, while chemical drugs are applied to eliminate the proteins that are produced. To efficiently deliver CRISPR‐chem drugs into brain lesions, traceable nano‐biohybrid complexes (F‐TBIO) are constructed by one‐step synthesis and CRISPR/Cas9 plasmids (CF‐TBIO) are loaded in a controllable manner. CF‐TBIO can knock out the BACE1 gene and reduce the burden of amyloid‐β, and thereby significantly improve the cognitive abilities of 2xTg‐AD mice. In particular, by prolonging the dosing interval, the pathological damage and behavioral abilities of 2xTg‐AD mice are still significantly improved. During the therapeutic process, CF‐TBIO with a high relaxation rate provides accurate imaging signals in the complex brain physiological environment. The finding shows that CF‐TBIO has great potential to serve as a CRISPR‐chem drug‐delivery platform for neurodegenerative diseases therapy.

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“…Results from fluorescence imaging showed a high targeting capacity and long retention times when compared to the non-imprinted control. Moreover, the tumor growth rate was significantly reduced with the proposed method [ 106 ].…”

Section: Molecular Imprinting For Te Applicationsmentioning

confidence: 99%

Molecular Imprinting Strategies for Tissue Engineering Applications: A Review

2021

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Tissue Engineering (TE) represents a promising solution to fabricate engineered constructs able to restore tissue damage after implantation. In the classic TE approach, biomaterials are used alongside growth factors to create a scaffolding structure that supports cells during the construct maturation. A current challenge in TE is the creation of engineered constructs able to mimic the complex microenvironment found in the natural tissue, so as to promote and guide cell migration, proliferation, and differentiation. In this context, the introduction inside the scaffold of molecularly imprinted polymers (MIPs)—synthetic receptors able to reversibly bind to biomolecules—holds great promise to enhance the scaffold-cell interaction. In this review, we analyze the main strategies that have been used for MIP design and fabrication with a particular focus on biomedical research. Furthermore, to highlight the potential of MIPs for scaffold-based TE, we present recent examples on how MIPs have been used in TE to introduce biophysical cues as well as for drug delivery and sequestering.

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Molecularly Imprinted Polymer‐Based Smart Prodrug Delivery System for Specific Targeting, Prolonged Retention, and Tumor Microenvironment‐Triggered Release

Cited by 112 publications

References 59 publications

Molecularly Imprinted Silk Fibroin Nanoparticles

Molecularly Imprinted Silk Fibroin Nanoparticles

Traceable Nano‐Biohybrid Complexes by One‐Step Synthesis as CRISPR‐Chem Vectors for Neurodegenerative Diseases Synergistic Treatment

Molecular Imprinting Strategies for Tissue Engineering Applications: A Review

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