Molecularly imprinted polymer of 5-methyluridine for solid-phase extraction of pyrimidine nucleoside cancer markers in urine

Jégourel, Damien; Delépée, Raphaël; Breton, Florent; Rolland, Antoine; Vidal, Richard; Agrofoglio, Luigi A.

doi:10.1016/j.bmc.2008.08.063

Cited by 41 publications

(23 citation statements)

References 53 publications

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“…[97] liberated during the RNA turnover. The modified nucleosides do not fit into the macromolecular nucleic acid structure, thus they cannot be reutilized for the de novo RNA synthesis and circulate freely in blood before elimination in urines by the same excretion pathway than normal nucleosides [98].…”

Section: Review Of the Literature Related To Mip-based Sensors Formentioning

confidence: 99%

MIP-Based Sensors: Promising New Tools for Cancer Biomarker Determination

Selvolini

Marrazza

2017

Sensors

145

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Detecting cancer disease at an early stage is one of the most important issues for increasing the survival rate of patients. Cancer biomarker detection helps to provide a diagnosis before the disease becomes incurable in later stages. Biomarkers can also be used to evaluate the progression of therapies and surgery treatments. In recent years, molecularly imprinted polymer (MIP) based sensors have been intensely investigated as promising analytical devices in several fields, including clinical analysis, offering desired portability, fast response, specificity, and low cost. The aim of this review is to provide readers with an overview on recent important achievements in MIP-based sensors coupled to various transducers (e.g., electrochemical, optical, and piezoelectric) for the determination of cancer biomarkers by selected publications from 2012 to 2016.

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Section: Review Of the Literature Related To Mip-based Sensors Formentioning

confidence: 99%

MIP-Based Sensors: Promising New Tools for Cancer Biomarker Determination

Selvolini

Marrazza

2017

Sensors

145

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“…Only few reports of the successful application of MIPbased solid-phase extraction (SPE) for the extraction and pre-concentration of nucleosides have already appeared in literature [19,20]. In particular, a MIP of 5-methyluridine has been used for the SPE of pyrimidine nucleosides from the urine [20].…”

Section: Introductionmentioning

confidence: 99%

“…In particular, a MIP of 5-methyluridine has been used for the SPE of pyrimidine nucleosides from the urine [20]. However, to the best of our knowledge, no report has yet demonstrated the development of MIPs which possessed both a high binding capacity and selectivity for only one specific modified nucleoside.…”

Section: Introductionmentioning

confidence: 99%

“…For the imprinting of polar compounds, such as nucleosides, the classical approach usually consists in the derivatization of the polar compounds into less polar analogues, such as acetylated nucleosides and nucleotides [21,22] or vinyl-phenylboronate ester derivatives of nucleosides [19,20]. This approach requires additional and not always simple steps in the preparation of imprinted polymers.…”

Section: Introductionmentioning

confidence: 99%

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Molecularly imprinted polymers for solid-phase extraction of 1-methyladenosine from human urine

Scorrano

Longo

Vasapollo

2010

Analytica Chimica Acta

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“…In recent years, MIPs as highly selective solid extraction sorbents have been widely used in separation, pre-concentration and determining, and thus molecular imprinting solid-phase extraction (MISPE) as a new technique was found. Now, MISPE technique has attracted increasing attention [18][19][20][21]. We think that MISPE is promising and has potential in the separation and purification of alkaloids.…”

Section: Introductionmentioning

confidence: 99%

Preparation and recognition performance of cytisine alkaloid‐imprinted material prepared using novel surface molecular imprinting technique

Gao

Niu

2010

J of Separation Science

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Methacrylic acid was first graft-polymerized on the surfaces of micron-sized silica gel particles in the manner of "grafting from" using 3-methacryloxypropyl trimethoxysilane as an intermedia, obtaining the grafted particle polymethacrylic acid PMAA/SiO(2). By adopting the novel surface-molecular imprinting technique put forward by us, cytisine molecule-imprinted material MIP-PMAA/SiO(2) was prepared with ethylene glycol diglycidyl ether as crosslinking agent. The binding characteristics of MIP-PMAA/SiO(2) towards cytisine was investigated in depth with both batch and column methods and using matrine and oxymatrine as two contrast alkaloids, which with cytisine coexist in sophora alopecuroides and their chemical structure is similar to cytisine to a certain extent. The experimental results show that the surface-imprinted material MIP-PMAA/SiO(2) has excellent binding affinity for cytisine (20.1 g/100 g of binding capacity), and it is more important that MIP-PMAA/SiO(2) has very high recognition selectivity for cytisine in relation to the two contrast alkaloids. The selectivity coefficients of the grafted particles PMAA/SiO(2) (non-imprinted material) for cytosine in relation to matrine and oxymatrine are only 1.03 and 1.06, respectively, displaying no recognition selectivity for cytisine. However, after imprinting, the selectivity coefficient of MIP-PMAA/SiO(2) for cytisine in respect to matrine and oxymatrine are remarkably enhanced to 12.08 and 15.05, respectively.

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Molecularly imprinted polymer of 5-methyluridine for solid-phase extraction of pyrimidine nucleoside cancer markers in urine

Cited by 41 publications

References 53 publications

MIP-Based Sensors: Promising New Tools for Cancer Biomarker Determination

MIP-Based Sensors: Promising New Tools for Cancer Biomarker Determination

Molecularly imprinted polymers for solid-phase extraction of 1-methyladenosine from human urine

Preparation and recognition performance of cytisine alkaloid‐imprinted material prepared using novel surface molecular imprinting technique

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