Molecularly imprinted polymeric coatings for sensitive and selective gravimetric detection of artemether

Arshad, Usman; Mujahid, Adnan; Lieberzeit, Peter A.; Afzal, Adeel; Bajwa, Sadia Z.; Iqbal, Naseer; Roshan, Sumaira

doi:10.1039/d0ra04785f

Cited by 15 publications

(9 citation statements)

References 37 publications

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“…Then, Ti 3 C 2 T x @CuFc-MOF/MIP is synthesized with polymerizing the MIP on the Ti 3 C 2 T x @CuFc-MOF. As illustrated in Figure d, Ti 3 C 2 T x @CuFc-MOF/MIP exhibited characteristic peaks of methacrylic acid (functional molecules of MIP) at 1728 and 1159 cm –1 , indicating the successful loading of the MIP on the heterostructure . It could also be observed from Figure S9a,b that abundant and dense MIPs are uniformly dispersed on the Ti 3 C 2 T x @CuFc-MOF.…”

Section: Resultsmentioning

confidence: 99%

Molecularly Imprinted Heterostructure-Based Electrochemosensor for Ultratrace and Precise Detection of 2-Methylisoborneol in Water

Xiao,

Zhu,

et al. 2024

ACS Sens.

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Ultratrace 2-methylisoborneol (2-MIB, ∼ng/L) in source water is the main odorant in the algae-derived odor episodes, whose accurate on-site detection will have a promising application potential. Due to the chemical inertness of 2-MIB, sensitive and selective detection of 2-MIB remains much challenging. Herein, molecularly imprinted polymer cavities were polymerized on the heterostructure Ti 3 C 2 T x @CuFc-metal−organic framework to selectively capture 2-MIB, where the heterostructure could catalyze the probe redox reaction of [Fe(CN) 6 3−/4− ] and amplify the corresponding current signals. The prepared electrochemical sensor showed higher sensitivity on 2-MIB detection than the reported ones. Excellent stability, reusability, and selectivity for 2-MIB detection were also verified. The linear range and limit of detection of our sensor for 2-MIB were optimized to 0.0001−100 μg/L and 30 pg/L, respectively, performing much better than the reported sensors. Comparable performance to gas chromatography−mass spectrometry was achieved when the sensor was applied to real water samples with or without 2-MIB standards. Overall, our research has made great progress in the application of an on-site sensor in 2-MIB detection and well advances the development of molecularly imprinted polymer-based electrochemical sensors.

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Section: Resultsmentioning

confidence: 99%

Molecularly Imprinted Heterostructure-Based Electrochemosensor for Ultratrace and Precise Detection of 2-Methylisoborneol in Water

Xiao,

Zhu,

et al. 2024

ACS Sens.

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“…We calculated the limit of detection (LoD) as 3.3 × (standard deviation of the intercept)/slope and the limit of quantification LoQ as 10 × (standard deviation of the intercept)/slope [ 40 ]. The standard deviation of this sensor was 17.7 Hz and the slope was 10.944, resulting in LoD values of 5.3 μg/mL (80 nM) and LoQ of 16.2 μg/mL (244 nM).…”

Section: Resultsmentioning

confidence: 99%

QCM-based assay designs for human serum albumin

2021

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Solid-phase synthesis is an elegant way to create molecularly imprinted polymer nanoparticles (nano-MIPs) comprising a single binding site, i.e. mimics of antibodies. When using human serum albumin (HSA) as the template, one achieves nano-MIPs with 53 ± 19 nm diameter, while non-imprinted polymer nanoparticles (nano-NIPs) reach 191 ± 96 nm. Fluorescence assays lead to Stern–Volmer plots revealing selective binding to HSA with selectivity factors of 1.2 compared to bovine serum albumin (BSA), 1.9 for lysozyme, and 4.1 for pepsin. Direct quartz crystal microbalance (QCM) assays confirm these results: nano-MIPs bind to HSA immobilized on QCM surfaces. This opens the way for competitive QCM-based assays for HSA: adding HSA to nanoparticle solutions indeed reduces binding to the QCM surfaces in a concentration-dependent manner. They achieve a limit of detection (LoD) of 80 nM and a limit of quantification (LoQ) of 244 nM. Furthermore, the assay shows recovery rates around 100% for HSA even in the presence of competing analytes.

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“…E5062A). The change of frequencies and damping values before/after coating and after washing the polymer was recorded and allowed us to estimate the respective layers' heights based on the experience of the group [31]. In addition, removal of the template molecules from the MIP film was also monitored by the network analyzer: Successful removal resulted in an increase of the resonance frequency of QCM after washing.…”

Section: Coating Process Of Thin Films On Qcmmentioning

confidence: 99%

Development of a MIP-Based QCM Sensor for Selective Detection of Penicillins in Aqueous Media

et al. 2021

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Pharmaceuticals wastes have been recognized as emerging pollutants to the environment. Among those, antibiotics in the aquatic environment are one of the major sources of concern, as chronic, low-dose exposure can lead to antibiotic resistance. Herein, we report on molecularly imprinted polymers (MIP) to recognize penicillin V potassium salt (PenV-K), penicillin G potassium salt (PenG-K), and amoxicillin sodium salt (Amo-Na), which belong to the most widespread group of antibiotics worldwide. Characterization and optimization led to two MIPs comprising methacrylic acid as the monomer and roughly 55% ethylene glycol dimethacrylate as the crosslinker. The obtained layers led to sensitive, selective, repeatable, and reusable sensor responses on quartz crystal microbalances (QCM). The LoD for PenV-K, PenG-K, and Amo-Na sensors are 0.25 mM, 0.30 mM, and 0.28 mM, respectively; imprinting factors reach at least around three. Furthermore, the sensors displayed relative selectivity factors of up to 50% among the three penicillins, which is appreciable given their structural similarity.

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Molecularly imprinted polymeric coatings for sensitive and selective gravimetric detection of artemether

Abstract: Chemical structures of the antimalarial drugs: artemisinin, artemether (a methyl ether derivative of artemisinin), and lumefantrine.

Cited by 15 publications

References 37 publications

Molecularly Imprinted Heterostructure-Based Electrochemosensor for Ultratrace and Precise Detection of 2-Methylisoborneol in Water

Molecularly Imprinted Heterostructure-Based Electrochemosensor for Ultratrace and Precise Detection of 2-Methylisoborneol in Water

QCM-based assay designs for human serum albumin

Development of a MIP-Based QCM Sensor for Selective Detection of Penicillins in Aqueous Media

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