Molecularly Imprinted Polymers (MIPs) in Sensors for Environmental and Biomedical Applications: A Review

Kadhem, Abbas J.; Gentile, Guillermina José; Cortalezzi, María Marta Fidalgo de

doi:10.3390/molecules26206233

Cited by 96 publications

(49 citation statements)

References 302 publications

(216 reference statements)

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“…MIPs are mechanically and chemically stable even at extreme pH and temperature values and, therefore, suitable for MIP-based sensors preparation even if they are single-use or multi-use [73,74]. Owing to these advantages, MIPs found applications in catalysis [75], immunoassays [30], separation [76] and sensing [77][78][79] procedures, in the pharmaceutical and medical fields [68,70,74,80], as well as in food [81,82] and environmental monitoring and control [68,70,80,83,84].…”

Section: Molecularly Imprinted Polymersmentioning

confidence: 99%

“…There are also some general reviews regarding the various types of electrochemical sensors (mainly modified with graphene [62][63][64] or nanomaterials [65,66]) and methods developed for antibiotic analysis [37,40,67]. Besides nanomaterials, MIPs are often chosen as electrode surface modifiers due to their ease of preparation and high stability, but mainly due to their inherent nature-inspired molecular recognition properties based on their tailored structure, which enhance both the selectivity and the sensitivity of the detection method owing to the preferred interaction with specific or closely related target molecules [68]. Our paper systematizes all types of carbon-based sensors modified both with MIPs alone and in combination with manifold other materials recently reported for antibiotic electroanalysis.…”

Section: Introductionmentioning

confidence: 99%

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Recent Trends in the Development of Carbon-Based Electrodes Modified with Molecularly Imprinted Polymers for Antibiotic Electroanalysis

et al. 2022

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Antibiotics are antibacterial agents applied in human and veterinary medicine. They are also employed to stimulate the growth of food-producing animals. Despite their benefits, the uncontrolled use of antibiotics results in serious problems, and therefore their concentration levels in different foods as well as in environmental samples were regulated. As a consequence, there is an increasing demand for the development of sensitive and selective analytical tools for antibiotic reliable and rapid detection. These requirements are accomplished by the combination of simple, cost-effective and affordable electroanalytical methods with molecularly imprinted polymers (MIPs) with high recognition specificity, based on their “lock and key” working principle, used to modify the electrode surface, which is the “heart” of any electrochemical device. This review presents a comprehensive overview of MIP-modified carbon-based electrodes developed in recent years for antibiotic detection. The MIP preparation and electrode modification procedures, along with the performance characteristics of sensors and analytical methods, as well as the applications for the antibiotics’ quantification from different matrices (pharmaceutical, biological, food and environmental samples), are discussed. The information provided by this review can inspire researchers to go deeper into the field of MIP-modified sensors and to develop efficient means for reliable antibiotic determination.

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Section: Molecularly Imprinted Polymersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent Trends in the Development of Carbon-Based Electrodes Modified with Molecularly Imprinted Polymers for Antibiotic Electroanalysis

et al. 2022

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“…Initiated by an inducer (catalyst, light, electricity, etc. ), functional monomer produces polymers with molecule templates via covalent or non-covalent forces, and after polymerization of the crosslinker, the polymers are branded with the size and shape of template molecules [ 41 , 42 ]. After removing the template, the polymers remain at binding sites that are complementary to a template.…”

Section: Brief Introduction Of Miecsmentioning

confidence: 99%

Towards Development of Molecularly Imprinted Electrochemical Sensors for Food and Drug Safety: Progress and Trends

et al. 2022

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Due to their advantages of good flexibility, low cost, simple operations, and small equipment size, electrochemical sensors have been commonly employed in food safety. However, when they are applied to detect various food or drug samples, their stability and specificity can be greatly influenced by the complex matrix. By combining electrochemical sensors with molecular imprinting techniques (MIT), they will be endowed with new functions of specific recognition and separation, which make them powerful tools in analytical fields. MIT-based electrochemical sensors (MIECs) require preparing or modifying molecularly imprinted polymers (MIPs) on the electrode surface. In this review, we explored different MIECs regarding the design, working principle and functions. Additionally, the applications of MIECs in food and drug safety were discussed, as well as the challenges and prospects for developing new electrochemical methods. The strengths and weaknesses of MIECs including low stability and electrode fouling are discussed to indicate the research direction for future electrochemical sensors.

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“…The research field has highlighted MIPbased electrochemical, mass-sensitive, and optical sensors and their advantages [22,23]. A comprehensive review of recent reports in the environmental and biomedical fields, with a focus on electrochemical and optical signaling mechanisms, has been presented [24].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Quartz Crystal Microbalance Biosensors Based on the Molecular Imprinting Technique for Disease-Related Biomarkers

2022

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The molecular imprinting technique is a quickly developing field of interest regarding the synthesis of artificial recognition elements that enable the specific determination of target molecule/analyte from a matrix. Recently, these smart materials can be successfully applied to biomolecule detection in biomimetic biosensors. These biosensors contain a biorecognition element (a bioreceptor) and a transducer, like their biosensor analogs. Here, the basic difference is that molecular imprinting-based biosensors use a synthetic recognition element. Molecular imprinting polymers used as the artificial recognition elements in biosensor platforms are complementary in shape, size, specific binding sites, and functionality to their template analytes. Recent progress in biomolecular recognition has supplied extra diagnostic and treatment methods for various diseases. Cost-effective, more robust, and high-throughput assays are needed for monitoring biomarkers in clinical settings. Quartz crystal microbalance (QCM) biosensors are promising tools for the real-time and quick detection of biomolecules in the past two decades A quick, simple-to-use, and cheap biomarkers detection technology based on biosensors has been developed. This critical review presents current applications in molecular imprinting-based quartz crystal microbalance biosensors for the quantification of biomarkers for disease monitoring and diagnostic results.

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Molecularly Imprinted Polymers (MIPs) in Sensors for Environmental and Biomedical Applications: A Review

Cited by 96 publications

References 302 publications

Recent Trends in the Development of Carbon-Based Electrodes Modified with Molecularly Imprinted Polymers for Antibiotic Electroanalysis

Recent Trends in the Development of Carbon-Based Electrodes Modified with Molecularly Imprinted Polymers for Antibiotic Electroanalysis

Towards Development of Molecularly Imprinted Electrochemical Sensors for Food and Drug Safety: Progress and Trends

Recent Advances in Quartz Crystal Microbalance Biosensors Based on the Molecular Imprinting Technique for Disease-Related Biomarkers

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