Molecularly Imprinted Sol-Gel-Based QCM Sensor Arrays for the Detection and Recognition of Volatile Aldehydes

Liu, Chuanjun; Wyszynski, Bartosz; Yatabe, Rui; Hayashi, Kenshi; Toko, Kiyoshi

doi:10.3390/s17020382

Cited by 39 publications

(23 citation statements)

References 54 publications

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“…When real body odor samples were tested, the presence of all target analytes detected by the QCM sensor arrays was confirmed by GC-MS measurements [138][139][140]. It could be shown by the selective detection of aldehydes with an array that molecularly imprinted sol-gels offer a promising alternative to MIPs [141]. Furthermore, utilizing a similar array with coatings made of MIP nanobeads for organic acid detection resulted in enhanced sensitivity and selectivity because of the nanobead structures [142].…”

Section: Qcm Multi-sensor Arraysmentioning

confidence: 80%

Bulk and Surface Acoustic Wave Sensor Arrays for Multi-Analyte Detection: A Review

Länge

2019

Sensors

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Bulk acoustic wave (BAW) and surface acoustic wave (SAW) sensor devices have successfully been used in a wide variety of gas sensing, liquid sensing, and biosensing applications. Devices include BAW sensors using thickness shear modes and SAW sensors using Rayleigh waves or horizontally polarized shear waves (HPSWs). Analyte specificity and selectivity of the sensors are determined by the sensor coatings. If a group of analytes is to be detected or if only selective coatings (i.e., coatings responding to more than one analyte) are available, the use of multi-sensor arrays is advantageous, as the evaluation of the resulting signal patterns allows qualitative and quantitative characterization of the sample. Virtual sensor arrays utilize only one sensor but combine it with enhanced signal evaluation methods or preceding sample separation, which results in similar results as obtained with multi-sensor arrays. Both array types have shown to be promising with regard to system integration and low costs. This review discusses principles and design considerations for acoustic multi-sensor and virtual sensor arrays and outlines the use of these arrays in multi-analyte detection applications, focusing mainly on developments of the past decade.

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Section: Qcm Multi-sensor Arraysmentioning

confidence: 80%

Bulk and Surface Acoustic Wave Sensor Arrays for Multi-Analyte Detection: A Review

Länge

2019

Sensors

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“…Instead of using organic polymers, Liu et al employed sol–gel materials for detecting volatile aldehyde vapors (Liu et al, 2017 ). These metabolic byproducts play an important role in oxidative stress as well as in cancer.…”

Section: Implementation Of Mips In Electronic Noses and Tonguesmentioning

confidence: 99%

Combining Two Selection Principles: Sensor Arrays Based on Both Biomimetic Recognition and Chemometrics

Cuypers

Lieberzeit

2018

Front. Chem.

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Electronic noses mimic smell and taste senses by using sensor arrays to assess complex samples and to simultaneously detect multiple analytes. In most cases, the sensors forming such arrays are not highly selective. Selectivity is attained by pattern recognition/chemometric data treatment of the response pattern. However, especially when aiming at quantifying analytes rather than qualitatively detecting them, it makes sense to implement chemical recognition via receptor layers, leading to increased selectivity of individual sensors. This review focuses on existing sensor arrays developed based on biomimetic approaches to maximize chemical selectivity. Such sensor arrays for instance use molecularly imprint polymers (MIPs) in both e-noses and e-tongues, for example, to characterize headspace gas compositions or to detect protein profiles. Other array types employ entire cells, proteins, and peptides, as well as aptamers, respectively, in multisensor systems. There are two main reasons for combining chemoselectivity and chemometrics: First, this combined approach increases the analytical quality of quantitative data. Second, the approach helps in gaining a deeper understanding of the olfactory processes in nature.

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“…The next paper [ 5 ] discusses the detection of several types of aldehydes. Hexanal, nonanal, and benzaldehyde were chosen as analytes.…”

Section: Summary Of the Special Issuementioning

confidence: 99%

Molecular Imprinting and Functional Polymers for All Transducers and Applications

Dickert

2018

Sensors

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Abstract:The main challenge in developing a chemical sensor is the synthesis of recognition coatings, which are very sensitive and selective to analytes of interest. Molecular imprinting has proven to be the most innovative strategy for this purpose in functional polymer design in the last few decades. Moreover, the introduction of functional groups brings about new applications for all available transducers. Sensitivity and selectivity features of sensor coatings can be tuned by this approach. The strategy produces molecular cavities and interaction sites in sensor coatings. The synthesis of these tailored recognition materials is performed in an outstanding manner, saving time and the high costs of chemicals. Furthermore, intermolecular interactions between the analyte and chemical layers will generate sites that are complementary to the analyte. This procedure can easily be done, directly on a transducer surface, which entails engulfing the analyte by a prepolymer and crosslinking the polymeric material. These imprinted polymers form a robust recognition layer on the transducer surface, which cannot be peeled off and can withstand very harsh conditions, both in gaseous and liquid media. These recognition materials are very suitable, for small molecules and even large bioparticles.

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Molecularly Imprinted Sol-Gel-Based QCM Sensor Arrays for the Detection and Recognition of Volatile Aldehydes

Cited by 39 publications

References 54 publications

Bulk and Surface Acoustic Wave Sensor Arrays for Multi-Analyte Detection: A Review

Bulk and Surface Acoustic Wave Sensor Arrays for Multi-Analyte Detection: A Review

Combining Two Selection Principles: Sensor Arrays Based on Both Biomimetic Recognition and Chemometrics

Molecular Imprinting and Functional Polymers for All Transducers and Applications

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