Molecularly or atomically precise nanostructures for bio-applications: how far have we come?

Wang, Jie; Li, Ping; Wang, Chao; Liu, Ning; Xing, Dongming

doi:10.1039/d3mh00574g

Cited by 2 publications

(1 citation statement)

References 188 publications

(276 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The applications of nanomaterials are widely and rapidly growing. The interest in their use in biomedicine has increased greatly in the past years as such materials embody an attractive framework where new tools for imaging, diagnostic, and therapeutic purposes are flourishing [1]. Within this field, mesoporous silica nanoparticles (MSNs) are rising as some of the most promising and customizable drug delivery systems [2,3].…”

Section: Introductionmentioning

confidence: 99%

Toxicological Profiling and Long-Term Effects of Bare, PEGylated- and Galacto-Oligosaccharide-Functionalized Mesoporous Silica Nanoparticles

Barguilla,

Candela-Noguera,

Oliver

et al. 2023

IJMS

View full text Add to dashboard Cite

Mesoporous silica nanoparticles (MSNs) are amongst the most used nanoparticles in biomedicine. However, the potentially toxic effects of MSNs have not yet been fully evaluated, being a controversial matter in research. In this study, bare MSNs, PEGylated MSNs (MSNs-PEG), and galacto-oligosaccharide-functionalized MSNs (MSNs-GAL) are synthesized and characterized to assess their genotoxicity and transforming ability on human lung epithelial BEAS-2B cells in short- (48 h) and long-term (8 weeks) exposure scenarios. Initial short-term treatments show a dose-dependent increase in genotoxicity for MSNs-PEG-treated cells but not oxidative DNA damage for MSNs, MSNs-PEG, or for MSNs-GAL. In addition, after 8 weeks of continuous exposure, neither induced genotoxic nor oxidative DNA is observed. Nevertheless, long-term treatment with MSNs-PEG and MSNs-GAL, but not bare MSNs, induces cell transformation features, as evidenced by the cell’s enhanced ability to grow independently of anchorage, to migrate, and to invade. Further, the secretome from cells treated with MSNs and MSNs-GAL, but not MSNs-PEG, shows certain tumor-promoting abilities, increasing the number and size of HeLa cell colonies formed in the indirect soft-agar assay. These results show that MSNs, specifically the functionalized ones, provoke some measurable adverse effects linked to tumorigenesis. These effects are in the order of other nanomaterials, such as carbon nanotubes or cerium dioxide nanoparticles, but they are lower than those provoked by some approved drugs, such as doxorubicin or dexamethasone.

show abstract

Section: Introductionmentioning

confidence: 99%

Toxicological Profiling and Long-Term Effects of Bare, PEGylated- and Galacto-Oligosaccharide-Functionalized Mesoporous Silica Nanoparticles

Barguilla,

Candela-Noguera,

Oliver

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

DNA‐Assisted Separation of Nanoparticles

Sun,

Liu,

Song

et al. 2024

Small Methods

View full text Add to dashboard Cite

DNA, as natural polymers, not only serves as the genetic material but also shows great potential as assistants for efficient and targeted nanoparticle separation. This is due to its high programmability, excellent biocompatibility, and stability for effectively binding with various types of nanoparticles or bioparticles, while modifying physical properties of target particles such as charge, mass and size. Researchers have achieved remarkable efficiency in separating nanoparticles by precisely designing DNA sequences and their interactions with target particles. This achievement primarily relies on the differences in physical properties of nanoparticles or medium modulated by DNA. In this minireview, diverse strategies are overviewed using DNA to assist nanoparticles separation, and the applications of these separation strategies are highlighted. Finally, the current challenges and prospects in DNA‐assisted nanoparticles separation are discussed.

show abstract

Molecularly or atomically precise nanostructures for bio-applications: how far have we come?

Abstract: A huge variety of nanostructures are promising for biomedical applications, but only a few have been practically applied. Among the various reasons, the limited structural preciseness is a critical one,...

Cited by 2 publications

References 188 publications

Toxicological Profiling and Long-Term Effects of Bare, PEGylated- and Galacto-Oligosaccharide-Functionalized Mesoporous Silica Nanoparticles

Toxicological Profiling and Long-Term Effects of Bare, PEGylated- and Galacto-Oligosaccharide-Functionalized Mesoporous Silica Nanoparticles

DNA‐Assisted Separation of Nanoparticles

Contact Info

Product

Resources

About