Molecularly targeted agents: Their promise as cancer chemopreventive interventions

Thiery-Vuillemin, A.; Nguyen, Thanh V.; Pivot, Xavier; Spano, Jean Philippe; Dufresnne, A.; Soria, Jean‐Charles

doi:10.1016/j.ejca.2005.06.005

Cited by 31 publications

(21 citation statements)

References 115 publications

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“…An investigation on human subjects has demonstrated that apigenin gets absorbed systemically by subjects fed with a diet high in parsley, resulting in the elevated levels of the antioxidant enzymes, erythrocyte glutathione reductase and superoxide dismutase 23 , with no alterations in their activities. Other biological effects induced by the metabolite include the reduction of plasma levels of low-density lipoproteins, inhibition of platelet aggregation, and reduction of cell proliferation [24][25][26][27] . This fact is apparent from another cross-sectional study conducted in Japan in which the total intake of flavonoids among women was found to be inversely correlated with plasma total cholesterol and low-density lipoprotein concentration 28 .…”

Section: Determination Of In Vitro Antioxidant and Metal Ion Chelatinmentioning

confidence: 99%

Foliar Biophenolic Antioxidant Metabolites of Alternanthera bettzickiana

Petrus¹,

Kalpana²,

Devi³

2014

Orient. J. Chem

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Alternanthera bettzickiana (Regel) Nicholson (Family: Amaranthaceae) is an erect herb and an ornamental pot plant, claimed to be useful in purifying and nourishing blood, in addition to the acclaimed soft laxative, galactagogue, antipyretic and wound healing characteristics. The tender leaves and shoots are commonly consumed like vegetable or spinach and in soups, either cooked alone or mixed with other vegetables and served with a staple food like rice or ugali. From the hydrophilic extract of the fresh leaves that exhibited in vitro antioxidant/radical scavenging (ABTS •+ and FRAP assays) and metal (Ferrous ion) chelating capacities, six biophenolic antioxidants, viz.,prop-2-enoic acid and (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid, have been isolated and characterised for the first time adopting extensive chromatographic and spectral studies.

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Section: Determination Of In Vitro Antioxidant and Metal Ion Chelatinmentioning

confidence: 99%

Foliar Biophenolic Antioxidant Metabolites of Alternanthera bettzickiana

Petrus¹,

Kalpana²,

Devi³

2014

Orient. J. Chem

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show abstract

“…In addition, other biological effects induced by flavonoids include lowering plasma levels of low-density lipoproteins, inhibiting platelet aggregation, and reducing cell proliferation (23,(25)(26)(27). These effects are related to their actions in inhibiting the cell cycle, diminishing oxidative stress, improving the efficacy of detoxification enzymes, inducing apoptosis, and stimulating the immune system (25)(26)(27). These inherent properties of flavonoids categorize them as a class of beneficial compounds which possess health-promoting and disease-preventing dietary effects, including efficacy in cancer prevention.…”

Section: Introductionmentioning

confidence: 99%

Apigenin and cancer chemoprevention: Progress, potential and promise (Review)

Patel

Shukla²,

Gupta³

2007

Int J Oncol

315

362

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Abstract. Cancer is one of the major public health burdens in the United States and in other developed countries, causing approximately 7 million deaths every year worldwide. Cancer rates vary dramatically in different regions and populations around the globe, especially between developing and developed nations. Changes in cancer prevalence patterns occur within regions as their populations age or become progressively urbanized. Migration has also contributed to such variations as changes in dietary habits influence cancer rates. These epidemiologic findings strongly suggest that cancer rates are influenced by environmental factors including diet, which is largely preventable. Approaches to prevent cancer include overlapping strategies viz. chemoprevention or dietary cancer prevention. Chemoprevention aims at prevention or reversal of the initiation phase of carcinogenesis or arrest at progression of carcinogenesis through the administration of naturally occurring constituents or pharmacological agents. Cancer prevention through diet may be largely achievable by increased consumption of fruits and vegetables. Considerable attention has been devoted to identifying plant-derived dietary agents which could be developed as promising chemopreventives. One such agent is apigenin. A naturally occurring plant flavone (4', 5, 7,-trihydroxyflavone) abundantly present in common fruits and vegetables including parsley, onions, oranges, tea, chamomile, wheat sprouts and some seasonings. Apigenin has been shown to possess remarkable anti-inflammatory, antioxidant and anti-carcinogenic properties. In the last few years, significant progress has been made in studying the biological effects of apigenin at cellular and molecular levels. This review examines the cancer chemopreventive effects of apigenin in an organ-specificity format, evaluating its limitations and its considerable potential for development as a cancer chemopreventive agent.

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“…It can be classified into primary in healthy individuals who have increased risk in developing cancer, secondary in individuals with already diagnosed premalignant lesions, and tertiary in patients who have been treated for a cancer and aims at preventing the development of a recurrence or a second primary tumor (9). Chemoprevention agents might be synthetic compounds or natural products.…”

Section: The Multistep Nature Of Respiratory Epithelium Carcinogenesismentioning

confidence: 99%

The Activator Protein-1 Transcription Factor in Respiratory Epithelium Carcinogenesis

Karamouzis

Konstantinopoulos²,

Papavassiliou³

2007

Molecular Cancer Research

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Respiratory epithelium cancers are the leading cause of cancer-related death worldwide. The multistep natural history of carcinogenesis can be considered as a gradual accumulation of genetic and epigenetic aberrations, resulting in the deregulation of cellular homeostasis. Growing evidence suggests that crosstalk between membrane and nuclear receptor signaling pathways along with the activator protein-1 (AP-1) cascade and its cofactor network represent a pivotal molecular circuitry participating directly or indirectly in respiratory epithelium carcinogenesis. The crucial role of AP-1 transcription factor renders it an appealing target of future nuclear-directed anticancer therapeutic and chemoprevention approaches. In the present review, we will summarize the current knowledge regarding the implication of AP-1 proteins in respiratory epithelium carcinogenesis, highlight the ongoing research, and consider the future perspectives of their potential therapeutic interest. (Mol Cancer Res 2007;5(2):109 -20)

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Molecularly targeted agents: Their promise as cancer chemopreventive interventions

Cited by 31 publications

References 115 publications

Foliar Biophenolic Antioxidant Metabolites of Alternanthera bettzickiana

Foliar Biophenolic Antioxidant Metabolites of Alternanthera bettzickiana

Apigenin and cancer chemoprevention: Progress, potential and promise (Review)

The Activator Protein-1 Transcription Factor in Respiratory Epithelium Carcinogenesis

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