Molecules and targets of antidiabetic interest

Gawli, Kavishankar; Bojja, Kavya Sritha

doi:10.1016/j.phyplu.2023.100506

Cited by 1 publication

(2 citation statements)

References 362 publications

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“…Therapeutic targeting of free fatty acid receptors, as proposed by Ichimura et al (2014), has been suggested for diabetes treatment. Free fatty acids act as ligands, influencing insulin secretion by interacting with Gprotein-coupled receptors on the plasma membrane, particularly the highly expressed free fatty acid receptor 1 (FFAR1 or GPR40) in beta cells (Oliveira de Souza et al, 2021;Gawli & Bojja, 2024). Braidy et al (2019) highlighted the therapeutic potential of nicotinamide adenine dinucleotide (NAD) and related precursors for age-related degenerative diseases, noting that NAD+ effectively restores normal blood glucose levels, indicating its ability to reduce blood sugar levels.…”

Section: Pathway Enrichment Patterns Of the Bioactive Constituentsmentioning

confidence: 99%

“…The conventional use of S. cumini seeds is attributed to their antioxidant potential, which stems from secondary derivatives like gallic acid, oxalic acid, tannic acid, quercetin, b-sitosterol, ferulic acid, guaiacol, catechin, epicatechin, tannic acid and certain alkaloids (Das et al, 2023). Natural antioxidant or antidiabetic molecules derived from plants are recognised for their cost-effectiveness, efficiency and lower toxicity compared with their synthetic counterparts (Gawli & Bojja, 2024). These natural molecules play a vital role in augmenting plasma, reducing cancer risk, mitigating heart and stroke diseases and are potential antidiabetic candidates.…”

Section: Introductionmentioning

confidence: 99%

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Exploring the antioxidant and antidiabetic potentials of Syzygium cumini L. landraces: phytochemicals, bioactive constituents and pathway enrichment analysis

Gajera,

Hirpara,

Gevariya

et al. 2024

Int J of Food Sci Tech

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SummaryThis study proposes an efficient antidiabetic strategy by identifying potential mechanisms of antioxidant metabolism and α‐amylase inhibition in Syzygium cumini L. fruits. Six indigenous landraces of S. cumini were evaluated for major phytochemicals and bioactive constituents using gas chromatography–mass spectrometry (GC–MS) profiling and correlated with antioxidant and antidiabetic properties. Black jamin landrace‐6 (BJLR‐6), characterised by small fruits, exhibited greater 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) scavenging activity and in vitro α‐amylase inhibition, especially in the kernel. The kernel of BJLR‐6 had the lowest IC50 for DPPH radicals (4.2 μg mL−1) and α‐amylase inhibition (5.3 μg mL−1). Therapeutic compounds like terpenoids in the pulp and alkaloids in the seed contribute to their curative potential. GC–MS profiling of BJLR‐6 revealed major bioactive constituents like propanamide, allantoic acid and 2‐furancarboxaldehyde in the pulp and alkaloids such as piperazine, 3‐pyridinol, imidazole and furan carboxaldehyde in the kernel tissues. Pathway enrichment analysis of bioactive constituents emphasises antioxidant and insulin‐regulating pathways, steroid hormone metabolism and signal transduction pathways associated with therapeutic/antidiabetic activity in fruit pulp and kernel tissues. This study unveils the phytochemical composition and novel bioactive constituents in the fruit parts of small‐fruited S. cumini BJLR‐6, emphasising their potential as a better source of functional herbal formulations.

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