Molecules of Cellular Adhesion Icam-1 and Vcam-1 in Infectious Pathology

Moskalets, O.V.

doi:10.17238/pmj1609-1175.2018.2.21-25

Cited by 15 publications

(7 citation statements)

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“…Receptors involved in lymphocyte-platelet adhesion are ICAM-1 ligands for β2-integrins (CD11a/ CD18, CD11b/CD18), LFA-1, Mac-1, and CD43 [9]. The content of cells carrying integrins was increased in all patients during the period of acute…”

Section: Resultsmentioning

confidence: 99%

Effect of dexamethasone therapy on factors of adhesiveness and coagulation in acute lower limb ischemia

Magamedov,

Pivovarova,

Platonov

et al. 2023

Med. immunol.

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Leukocyte-platelet adhesion during hypoxia, tissue damage, activation of inflammation and coagulation is associated with the expression of ICAM-1 membrane molecules and integrins by blood and tissue cells. At the same time, platelet adhesion receptors determine their adhesion to the endothelium and recruited lymphocytes. The role of platelets in the pathogenesis of ischemic cardiovascular diseases also consists in their ability to modulate both hemostasis and inflammatory reactions, which is accompanied by the secretion of inflammatory mediators and factors that promote the recruitment of leukocytes to tissue damage sites. Purpose of the study: to study the effect of the synthetic glucocorticoid dexamethasone on the expression of adhesion receptors CD18+ and CD54+ on leukocytes, the content of platelets and fibrinogen in the blood of patients with ALLI, the relationship of these indicators with the severity and outcome of the disease.To study the effect of anti-inflammatory therapy, a group of 32 patients treated with dexamethasone was formed; the comparison group was represented by 71 patients with basic therapy, the control group consisted of 15 volunteers. After revascularization, all patients received antiplatelet and anticoagulant therapy. Dexamethasone infusions were carried out in a course of 4 to 6 days after reconstructive surgery. In all patients, the content of C-reactive protein in the blood, the content of platelets and fibrinogen were determined. The number of lymphocytes expressing adhesion molecules ICAM-1 (CD54+) and integrins (CD18+) was counted using the immunocytochemical method. Studies were performed before surgery and on days 1, 3, 7, and 10 after surgery.With exacerbation of ischemia and damage to the endothelium, the accumulation of cytolysis products, the expression of adhesion molecules increases both on endotheliocytes and on inflammatory effector cells – leukocytes and platelets. Adhesion molecules conduct an activation signal inside the cell, which promotes adhesion of leukocytes and platelets to the endothelium, lymphocytic-platelet adhesion, the formation of a parietal thrombus, and possible occlusion of damaged vessels. Increased expression of adhesion molecules is associated with the activation of metabolism, inflammation, coagulation and oxidative stress, stimulates all hematopoietic lineages, including platelets. The level of involvement of cellular reactions in the pathogenesis of the disease affects the effectiveness and duration of treatment, the risk of recurrent thrombosis and death. Anti-inflammatory therapy with dexamethasone contributed to earlier remission, a decrease in the proportion of infectious complications, such as wound suppuration from 10% to 6%, the number of necessary amputations from 32% to 16%, the frequency of deaths from 31% to 6%, and a reduction in hospital stay from 13 days to 10.Inflammation, adhesiveness of effector cells and thrombosis are important factors in the pathogenesis of acute lower limb ischemia. Therapy with dexamethasone helps to reduce the level of systemic inflammatory response, the number of necessary amputations, the number of complications and adverse outcomes in the treatment of ALLI, and reduce the length of stay in the hospital.

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Section: Resultsmentioning

confidence: 99%

Effect of dexamethasone therapy on factors of adhesiveness and coagulation in acute lower limb ischemia

Magamedov,

Pivovarova,

Platonov

et al. 2023

Med. immunol.

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Section: Introductionmentioning

confidence: 99%

“…The severity of the course, frequent relapses, insufficient the effectiveness of common therapy force us to continue the search for more effective methods for predicting the development of these complications, including laboratory assays. Various markers of inflammation and endothelial disfunction, as well as autoantibody levels are quite promising [2,3,5].In connection with the above, the purpose of this study was to determine the value of some immunological markers in exudative iridocyclitis and endophthalmitis after pseudophakia.Material and methods. The study included 26 patients (10 men and 16 women) aged 45 to 80 years with exudative iridocyclitis and endophthalmitis developed after phacoemulsification aboratory studies were performed twice (on the 2-3 day after admission to the hospital and before discharge) and included determination of the level of antibodies to double-stranded DNA (anti-DNA), soluble adhesion molecules (sICAM-1, sVCAM-1) and neopterin.…”

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confidence: 99%

Predictors of outcomes of postoperative inflammatory reactions after intraocular lens implantation

Moskalets¹

2021

Scientific Achievements of the Third Millennium

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Introduction.Exudative iridocyclitis and endophthalmitis after cataract extraction with implantation of intraocular lens (IOL) presently remain an urgent problem in ophthalmosurgery. According to various authors, the incidence of postoperative iridocyclitis ranges from 1 to 37.8% [1]. The severity of the course, frequent relapses, insufficient the effectiveness of common therapy force us to continue the search for more effective methods for predicting the development of these complications, including laboratory assays. Various markers of inflammation and endothelial disfunction, as well as autoantibody levels are quite promising [2,3,5].In connection with the above, the purpose of this study was to determine the value of some immunological markers in exudative iridocyclitis and endophthalmitis after pseudophakia.Material and methods. The study included 26 patients (10 men and 16 women) aged 45 to 80 years with exudative iridocyclitis and endophthalmitis developed after phacoemulsification aboratory studies were performed twice (on the 2-3 day after admission to the hospital and before discharge) and included determination of the level of antibodies to double-stranded DNA (anti-DNA), soluble adhesion molecules (sICAM-1, sVCAM-1) and neopterin. The follo-up period was 6 months. We used test systems from IBL (Austria), Orgentec (Germany), Bender MedSystems (Austria).Results. Exudative reactions (ER) occurred in all patients at different times after surgery (from 2 to 14 days). The severity of ER distribution was as follows: II degree -12 patients (46,1%), III degree -11 patients (42,3%), IY degree -3 patients (11,3%).The initial levels anti-DNA was increased in 14 (53,8%) patients, neopterin in 11 (42,3%), sICAM-1 in 3 (11,5%), sVCAM-1 in 5 (19,2%). No correlations with the timing of the development of EVR and its severity were revealed. There was a large scatter of individual indicators.Monitoring of these indicators demonstrated, that normalization of anti-DNA levels occurred in 9 patients, while in 5 it significantly decreased compared to the initial level. At the same time, in 1 patient with severe postoperative endophthalmitis, this indicator increased even more. This fact may be due to increased apoptosis.In 6 patients neopterin levels decreased to normal ranges but in 2 cases it remained elevated. It should be noted that in 1 patient this indicator before discharge from the hospital increased significantly compared to the initial normal value, although the course of the disease was favorable and no complications and relapses were noted later.Patient monitoring revealed the following. In 1 patient with endophthalmitis, the most unfavorable outcome was eye removal. At the same time, he also had the highest initial level of sVCAM-1 (3472 ng / ml), a high level of neopterin (20.6 nmol / L), both of which rapidly increased. The second patient with endophthalmitis had an initially high level of anti-DNA; before discharge, it increased by almost 5 times, but the remaining indicators practically did not exceed normal...

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“…Predicting the course and outcome of EVR is quite difficult, therefore, the search for laboratory markers that allow this to be done seems quite relevant. Potential candidates include various markers of inflammation and endothelial disfunction, as well as autoantibodies [2,3,5].…”

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confidence: 99%

Molecules of Cellular Adhesion Icam-1 and Vcam-1 in Infectious Pathology

Cited by 15 publications

References 0 publications

Effect of dexamethasone therapy on factors of adhesiveness and coagulation in acute lower limb ischemia

Effect of dexamethasone therapy on factors of adhesiveness and coagulation in acute lower limb ischemia

Predictors of outcomes of postoperative inflammatory reactions after intraocular lens implantation

Potential predictors of outcomes of exudative inflammatory reaction in pseudophakia

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