“…The crude product was purified by column chromatography (SiO 2 ,C H 2 Cl 2 /petroleum ether = 1:4v /v) to obtain aw hite solid (6.50 g, 66. 3, 14.8, 7.4 Hz, 7H), 6.89 (t, J = 7.5 Hz, 1H), 6.81 (d, J = 7.4 Hz, 5H), 6.69 (d, J = 7.8 Hz, 1H), 6.63 ppm (d, J = 7.8 Hz, 1H); MS (MALDI-TOF): m/z:4 11.044;e lemental analysis calcd (%) for C 25 H 18 BrN (412.32): C7 2.82,H4 .40,N3 .40;f ound:C72.59,H4 .85,- [1,1'-biphenyl]-4-carbonitrile (3):K 2 CO 3 (16.8 g, 122 mmol), 2 (5.0 g, 12.2 mmol), 4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- [1,1'-biphenyl]-4-carbonitrile [26] (4.45 g, 14.6 mmol), and Pd(PPh 3 ) 4 (0.28 g, 0.24 mmol) were added to at oluene/ethanol/water mixture (10:2:1, v/v/v) under aN 2 atmosphere. The mixture was heated to reflux overnight.…”