Mollaret's meningitis responding to phenylbutazonum

Limburg, M.; Feenstra, Louw; Lecluse, F. L. E.; Muller, H.P.

doi:10.1016/0303-8467(85)90110-6

Cited by 8 publications

(2 citation statements)

References 11 publications

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“…Although acyclovir is a safe, effective, and specific anti-Herpes drug, 10,11 it has not been shown to definitively alter the natural history of the disease, whereas other therapies, including estrogen, steroids, antihistamine, phenylbutazonum, and colchicine have been unsuccessful in the treatment of Mollaret meningitis. 12,13 The case we present is an interesting case of Mollaret meningitis, with numerous reoccurrences spanning a period of 20 years. To our knowledge, this is the largest number of recurrent episodes documented to occur in an individual patient.…”

Section: Discussionmentioning

confidence: 95%

Recurrent Herpes Simplex Type 2 Virus (Mollaret) Meningitis

Mirakhur

McKenna²

2004

The Journal of the American Board of Family Medicine

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Section: Discussionmentioning

confidence: 95%

Recurrent Herpes Simplex Type 2 Virus (Mollaret) Meningitis

Mirakhur

McKenna²

2004

The Journal of the American Board of Family Medicine

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“…the lack of colchicine effect on plasma IFN-γ levels reported in the patients with FMF (Koklu et al, 2005), as well as the induction of neuronal NOS and inducible NOS expressions in the central and peripheral catecholaminergic neurons by colchicine (Vanhatalo, Lumme, & Soinila, 1998;Dufourny, Leroy, & Warembourg, 2000), also may, at least in part, explain failure of this drug in the treatment of some subjects with MM (Stamm et al, 1984)]. Moreover, therapy of few patients with MM with indomethacin (Wynants, Taelman, Martin, & Van den Ende, 2000;Ikari et al, 1993) or phenylbutazone (Limburg, Feenstra, Lecluse, & Muller, 1985) resulted in a faster recovery and longer symptom-free intervals between episodes. This favorable effect of indomethacin may, at least in part, be explained by its action preventing increased catecholamines turnover in the brain (Masana, Heyes, & Mefford, 1990) with normalization of their excretion with urine (Schmollack & Steup, 1988).…”

Section: Metaraminolmentioning

confidence: 99%

Mollaret Meningitis may be Caused by Reactivation of Latent Cerebral Toxoplasmosis

Prandota

2009

International Journal of Neuroscience

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Mollaret meningitis (MM) occurs mainly in females and is characterized by recurrent episodes of headache, transient neurological abnormalities, and the cerebrospinal fluid containing mononuclear cells. HSV-2 was usually identified as the causative agent. Recently, we found that recurrent headaches in non-HIV-infected subjects were due to acquired cerebral toxoplasmosis (CT). The aim of the study was therefore to focus on molecular pathomechanisms that may lead to reactivation of latent CT and manifest as MM. Literature data cited in this work were selected to illustrate that various factors may affect latent CNS Toxoplasma gondii infection/inflammation intensity and/or host defense mechanisms, i.e., the production of NO, cytokines, tryptophan degradation by indoleamine 2,3-dioxygenase, mechanisms mediated by an IFN-gamma responsive gene family, limiting the availability of intracellular iron to T. gondii, and production of reactive oxygen/nitrogen species, finally inducing choroid plexitis and/or vasculitis. Examples of triggers revealing MM and accompanying disturbances of IFN-gamma-mediated immune responses that control HSV-2 and T. gondii include: female predominance (female mice are more susceptible to T. gondii infection than males); HSV-2 infection (increased IFN-gamma, IL-12); metaraminol (increased plasma catecholamine levels, changes in cytokine expression favoring T(H)2 cells responses); probably cholesterol contained in debris from ruptured epidermoid cysts (decreased NO; increased TNF-alpha, IL-6, IL-8). These irregularities induced by the triggers may be responsible for reactivation of latent CT and development of MM. Thus, subjects with MM should have test(s) for T. gondii infection performed obligatorily.

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Mollaret's meningitis: CSF-immunocytological examinations

1987

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Mollaret's meningitis is a rare clinical entity consisting of recurrent attacks of meningeal irritation, which, after a sudden onset, last for a few days. The prognosis appears to be excellent, although the aetiology has not been established. In the CSF so-called endothelial cells are a typical finding, but their classification is not yet clear. In the present case immunocytological examination of CSF cells revealed that the so-called Mollaret cells are monocytes. The time course of changes in helper/suppressor ratio is similar to that in other infectious diseases of the central nervous system.

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Mollaret's meningitis responding to phenylbutazonum

Cited by 8 publications

References 11 publications

Recurrent Herpes Simplex Type 2 Virus (Mollaret) Meningitis

Recurrent Herpes Simplex Type 2 Virus (Mollaret) Meningitis

Mollaret Meningitis may be Caused by Reactivation of Latent Cerebral Toxoplasmosis

Mollaret's meningitis: CSF-immunocytological examinations

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