Molluscicidal properties of glycoalkaloid extracts from MoroccanSolanum species

Bekkouche, Khalid; Markouk, Mohamed; Larhsini, Mustapha; Jana, M.; Lazrek, H. B.

doi:10.1002/1099-1573(200008)14:5<366::aid-ptr640>3.0.co;2-e

Cited by 17 publications

(19 citation statements)

References 8 publications

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“…The molluscicidal activity of the genus Solanum was widely studied and gave promising results, especially in glycoalkaloid and saponin fractions (Bagalwa et al, 2010;Bekkouche et al, 2000;Wanyonyi et al, 2002). As an extension to this field, the present data revealed the effect of Solanum elaeagnifolium on Galba truncatula snails.…”

Section: Discussionsupporting

confidence: 93%

“…According to the literature, this plant showed a potent effect on snails. In fact, glycoalkaloid extract of its berries exhibited a molluscicidal activity against Bulinus truncatus with an LC 50 of 9.5 mg/L (Bekkouche et al, 2000). Further investigations on this extract led to the isolation of six fractions among which three were very active, giving an LC 50 value of 4, 6, and 10 mg/L, but their compositions were not determined.…”

Section: Discussionmentioning

confidence: 99%

“…It is regarded as a rapid and efficient method for reducing or eliminating transmission and is among the methods of choice to bring these diseases under an adequate control through the breakage of the life cycle of the parasite. In fact, several plant extracts were found out to be toxic to snails that are responsible for the spread of many human and animal infections, especially in tropical regions (Bagalwa et al, 2010;Bekkouche et al, 2000;Wanyonyi et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Molluscicidal activity ofSolanum elaeagnifoliumseeds againstGalba truncatulaintermediate host ofFasciola hepatica: Identification ofβ-solamarine

Njeh

Feki

Koubaa

et al. 2015

Pharmaceutical Biology

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Context: The persistence of fascioliasis in many developing countries urges the search for simple, cheap, and effective substances. In this view, plants provide interesting molluscicidal activities thanks to the secondary metabolites they produce. The genus Solanum is known for its potent effect on vector snails. Materials and methods: Solanum elaeagnifolium seeds were powdered and successively extracted using n-hexane, methylene chloride, acetone, and methanol, for 20 h each. After filtration, solvents were evaporated. An acid-base treatment was conducted on seed methanolic extract to isolate total alkaloids and b-solamarine. Total saponins fraction was obtained after successive macerations and evaporations. The molluscicidal activity was evaluated by subjecting snails, in groups of 10, for 48 h to 500 mL of extracts, fractions, and pure product aqueous solutions, each containing amounts, ranging from 1 to 50 mg of plant material in 5 mg increments. Results: The methanolic extract of seeds, b-solamarine isolated for the first time from this plant and total saponins fraction showed very potent activities on snails, giving respective median lethal concentrations (LC 50 ) of 1.18, 0.49, and 0.94 mg/L. Total alkaloids fraction obtained from the methanolic extract was less active giving an LC 50 value of 14.67 mg/L. Discussion and conclusion: This study emphasizes that glycoalkaloids and saponins of Solanum elaeagnifolium are potent molluscicidal agents. Seed methanolic extract, b-solamarine, and total saponins fraction may be used as molluscicides.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Molluscicidal activity ofSolanum elaeagnifoliumseeds againstGalba truncatulaintermediate host ofFasciola hepatica: Identification ofβ-solamarine

Njeh

Feki

Koubaa

et al. 2015

Pharmaceutical Biology

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“…In the search for plants with molluscicidal activity, several extracts have been found to be toxic to the snails that carry schistosomes or other important parasites (Hostettmann, 1980). In the last two decades, for example, extracts of berries from the shrub Phytolacca dodecandra, commonly known as 'endod' (Lemma, 1965), and of several species of Solanum have been found to have significant and potentially useful molluscicidal activity (Medina and Woodbury, 1979;Medina and Ritchie, 1980;Alzerreca et al, 1981;Kloos et al, 1987;Mkoji et al, 1989;Odyek et al, 1992, Ahmed andRamzy, 1997;Bekkouche et al, 2000;Wei et al, 2002;Wanyonyi et al, 2003).…”

supporting

confidence: 52%

Molluscicidal activity of some BrazilianSolanumspp. (Solanaceae) againstBiomphalaria glabrata

Silva

Batista

Câmara

et al. 2005

Annals of Tropical Medicine & Parasitology

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Plants in the genus Solanum (Solanaceae) produce a great variety of steroidal saponins and glycoalkaloids that confer natural resistance against several pests. Methanolic extracts of 13 Solanum species have now been tested for molluscicidal activity against Biomphalaria glabrata. The extracts investigated were prepared from the fruit of S. asperum, S. capsicoides, S. palinacantum, S. paludosum, S. paniculatum, S. paraibanum and S. sisymbriifolium, the aerial parts of S. asperum, S. capsicoides, S. crinitum, S. diamantinense, S. megalonyx, S. palinacantum, S. paniculatum, S. sisymbriifolium and S. torvum, and the roots of S. asperum, S. asterophorum, S. palinacantum, S. paludosum, S. paniculatum and S. stipulaceum. Encouragingly, the extracts from S. asperum, S. diamantinese, S. paludosum, S. sisymbriifolium and S. stipulaceum showed significant molluscicidal activity, the median lethal concentrations recorded (20-50 microg/ml) falling well below the threshold, of 100 microg/ml, set for a potential molluscicide by the World Health Organization.

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“…Several articles had reported on different biological activities of the above species, namely, anti-inflammatory and molluscicidal properties of Agave americana (Shoeb et al, 1984;Peana et al, 1997), molluscicidal activity of Agave lophantha (El-Sayed et al, 1991), anti-inflammatory activity of Calotropis procera (Kumar & Basu, 1994), hypoglycemic activity of Pergularia tomentosa (Shabana et al, 1990), antiviral activity of Alkanna orientalis (El-Sohly et al, 1997), antibacterial, antinociceptive, and antiinflammatory effects of Pimenta racemosa Saenz et al, 2004), antimicrobial activities of Verbascum sinaiticum (Tadeg et al, 2005), molluscicidal properties of Solanum elaeagnifolium (Bekkouche et al, 2000), and molluscicidal and cercaricidal activities of Solanum nigrum (Ahmed & Ramzy, 1997).…”

Section: Resultsmentioning

confidence: 99%

Large-scalein Vitro. Screening of Egyptian Native and Cultivated Plants for Schistosomicidal Activity

Yousif

Hifnawy

Soliman

et al. 2007

Pharmaceutical Biology

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In vitro bioassay screening of 346 methanol extracts originated from 281 native and cultivated plant species growing in Egypt, and related to 81 families, was carried out for schistosomicidal activity. The extracts were bioassayed at 100 mg=mL on viable Schistosoma mansoni mature worms in culture medium. Viability of worms was examined after exposure for 24 h, and mortality determined. Negative (DMSO) and positive (praziquantel) controls were used. Of the tested plant extracts, 72 were found to possess reproducible in vitro antischistosomal activity. These active extracts were further subjected to determination of their LC 50

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Molluscicidal properties of glycoalkaloid extracts from MoroccanSolanum species

Cited by 17 publications

References 8 publications

Molluscicidal activity ofSolanum elaeagnifoliumseeds againstGalba truncatulaintermediate host ofFasciola hepatica: Identification ofβ-solamarine

Molluscicidal activity ofSolanum elaeagnifoliumseeds againstGalba truncatulaintermediate host ofFasciola hepatica: Identification ofβ-solamarine

Molluscicidal activity of some BrazilianSolanumspp. (Solanaceae) againstBiomphalaria glabrata

Large-scalein Vitro. Screening of Egyptian Native and Cultivated Plants for Schistosomicidal Activity

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