Molluscum sebaceum

Calnan, C. D.; Haber, H.

doi:10.1002/path.1700690110

Cited by 39 publications

(8 citation statements)

References 17 publications

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“…Treatment with 800–1500 r of X‐irradiation has also been reported to be useful,, and caused impressive, albeit only temporary, regression in our patient. If larger doses such as are administered for squamous‐cell carcinoma are given, cure seems assured ,…”

Section: Discussionsupporting

confidence: 62%

Keratoacanthoma Recurrent After Surgical Excision

Epstein

1978

The Journal of Dermatologic Surgery and Oncology

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A 62-year-old man developed a recurrent keratoacanthoma within two and a half weeks after grossly and microscopically complete removal of the primary tumor. X-irradiation of the recurrent lesion caused partial regression, and then intralesional injections of a suspension of triamicinolone caused final resolution of it. Although dermatologists generally practice partial destruction and surgeons almost always do total excision, neither method invariably cures this benign tumor, and repeated treatment may be necessary.

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Section: Discussionsupporting

confidence: 62%

Keratoacanthoma Recurrent After Surgical Excision

Epstein

1978

The Journal of Dermatologic Surgery and Oncology

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“…These lectin histochemical observations suggest a differentiation of the glandular structure into an apocrine duct, matching the lectin binding patterns of normal sweat glands and sweat gland tumors in the previous reports (3)(4)(5)(6)(7). On the other hand, KA probably originates from the infundibulum of one or several hair follicles (8,9). From this point of view, the facts that the tumor of our case was located on the cheek and that a few apocrine glands associated with hair follicles exist on the face (10) are suggestive.…”

Section: Discussionmentioning

confidence: 56%

Keratoacanthoma with Glandular Proliferation

Akiyama

Hata

Nishikawa

1993

The Journal of Dermatology

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A case of keratoacanthoma (KA) with glandular proliferation was reported. The tumor was a firm, dome-shaped, elevated nodule on the cheek of an 82-year-old Japanese male. Generally, the tumor showed the typical histopathological features of KA; slight nuclear atypia and mitotic figures were present in a cup-shaped proliferation of keratinocytes and, in the center of the lesion, a keratin-filled crater with nests of dyskeratotic and acantholytic cells was seen. In the bottom of the lesion, a glandular structure forming branching, thin lumina was observed. The epithelium of the lumina was made up of two or more layers of columnar or cuboidal cells without keratinization. Tall columnar cells with oval nuclei were located in the luminal row and small cuboidal cells with round nuclei and scanty cytoplasm were in the outer layer. Immunohistochemical staining revealed that only the glandular structure was carcinoembryonic antigen positive. Lectin binding patterns observed in the glandular proliferation were similar to those reported for the apocrine gland. KA sometimes exhibits an adenoid structure in its lesion because of acantholytic changes. However, KA associated with true glandular proliferation has not been reported as far as we know, and our case is the first reported one. KA is thought to be a tumor of follicular origin, and the glandular proliferation observed in the present case seemed to have certain characteristics that suggest its apocrine origin.

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“…O'Donovan ( 1920) in discussing skin cancer among tar workers illustrates two examples of large tumours arising within two months and showing all the features of molluscum sebaceum. Such an association with tar workers has been common in patients with this condition ( Calnan and Haber, 1955) and the "tar wart" with its frequently benign clinical course, has in many cases been identified with the molluscum sebaceum (Klaber, 1936). While Dupont ( 1930) has been credited with first recognizing the true nature of this lesion under the term kysth sebace' atypique, its first description in Eritish literature was the very clear correlation of the clinical and histological features by MacCormac and Scarff (1936).…”

Section: Historicalmentioning

confidence: 91%