Moluccensins R–Y, Limonoids from the Seeds of a Mangrove, <i>Xylocarpus moluccensis</i>

Li, Jun; Li, Minyi; Feng, Gang; Zhang, Jing; Karonen, Maarit; Sinkkonen, Jari; Satyanandamurty, Tirumani; Wu, Jun

doi:10.1021/np300053f

Cited by 40 publications

(33 citation statements)

References 36 publications

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“…The Rhus genus is also a rich source for biflavonoids and bischalcones. In general, naturally occurring bischalcones, rhuschalcone (I), littorachalcone (II), and verbenachalcone (III) as depicted in Figure 1 carry either a C-O-C or C-C linkage between the two chalcone fragments [8][9][10][11]. Rhuschalcone II-VI has been isolated from the root bark of Rhus pyroides and synthetic analogs have been shown to possess strong antiplasmodial and moderate antiproliferative, antiprotozoal activities.…”

Section: Introductionmentioning

confidence: 99%

“…Rhuschalcone II-VI has been isolated from the root bark of Rhus pyroides and synthetic analogs have been shown to possess strong antiplasmodial and moderate antiproliferative, antiprotozoal activities. In addition, rhuschalcone (I) displays important cytotoxic activity against the HT29 and HCT-116 colon tumor cell lines [9,11,12]. Its dihydro analogs, bearing diaryl ether linkage, both littorachalcone (II) and verbenachalcone (III), showed a significant extension of nerve growth factor-mediated neurite outgrowth from the PC12D cells [10,11].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Biological Evaluation of Novel Bischalcone Derivatives as Carbonic Anhydrase Inhibitors

Arslan

Çelik

Celik

et al. 2016

Archiv der Pharmazie

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Design and synthesis of a new type of bischalcones as an alternative to natural and synthetic bischalcones are reported for the first time. Key steps involved the solvent-free Claisen-Schmidt condensation of chalcones, and the successful first application of the diazotization-diazocoupling reaction in the synthesis of CNNC-linked bischalcones by simple structural modification of p-aminoacetophenone. The structures of all compounds were confirmed by means of FT-IR, (1) H and (13) C NMR, ESI/MS, and elemental analysis. In addition, the newly synthesized compounds were screened for carbonic anhydrase inhibition activities. Almost all bischalcones exhibited moderate-to-good inhibitory activities.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of Novel Bischalcone Derivatives as Carbonic Anhydrase Inhibitors

Arslan

Çelik

Celik

et al. 2016

Archiv der Pharmazie

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“…Seeds : Triterpenoids : limonoids [190,247,248,253,254,255,256,257,258,259,260,261], tirucallane-type triterpenoids [260]; Protein , minerals and fatty acids [262]. …”

Section: Traditional Antidiarrhoeal Plants From Bangladeshmentioning

confidence: 99%

Can Scientific Evidence Support Using Bangladeshi Traditional Medicinal Plants in the Treatment of Diarrhoea? A Review on Seven Plants

et al. 2013

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Diarrhoea is a common disease which causes pain and may be deadly, especially in developing countries. In Bangladesh, diarrhoeal diseases affect thousands of people every year, and children are especially vulnerable. Bacterial toxins or viral infections are the most common cause of the disease. The diarrhoea outbreaks are often associated with flood affected areas with contaminated drinking water and an increased risk of spreading the water-borne disease. Not surprisingly, plants found in the near surroundings have been taken into use by the local community as medicine to treat diarrhoeal symptoms. These plants are cheaper and more easily available than conventional medicine. Our question is: What is the level of documentation supporting the use of these plants against diarrhoea and is their consumption safe? Do any of these plants have potential for further exploration? In this review, we have choosen seven plant species that are used in the treatment of diarrhoea; Diospyros peregrina, Heritiera littoralis, Ixora coccinea, Pongamia pinnata, Rhizophora mucronata, Xylocarpus granatum, and Xylocarpus moluccensis. Appearance and geographical distribution, traditional uses, chemical composition, and biological studies related to antidiarrhoeal activity will be presented. This review reveals that there is limited scientific evidence supporting the traditional use of these plants. Most promising are the barks from D. peregrina, X. granatum and X. moluccensis which contain tannins and have shown promising results in antidiarrhoeal mice models. The leaves of P. pinnata also show potential. We suggest these plants should be exploited further as possible traditional herbal remedies against diarrhoea including studies on efficacy, optimal dosage and safety.

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“…[ 11,13 ] Graphene oxide exhibits potential as a solution-processable, fl exible material, for fabricating graphene-based composites due to its outstanding mechanical properties, fl exible 2D structure, high binding potential and single/double atomic layers that can easily turn into a conductive reduced-graphene oxide (rGO) form. [14][15][16][17] Biomedical applications such as drug/gene delivery and biocomposites with high colloidal stability and biocompatibility have been reported. [18][19][20] Importantly, in spite of structural defects, the elastic modulus of graphene oxide is still very high, around 0.25 TPa.…”

Section: Introductionmentioning

confidence: 99%

Robust Microcapsules with Controlled Permeability from Silk Fibroin Reinforced with Graphene Oxide

Combs

Calabrese

et al. 2014

Small

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Robust and stable microcapsules are assembled from poly-amino acid-modified silk fibroin reinforced with graphene oxide flakes using layer-by-layer (LbL) assembly, based on biocompatible natural protein and carbon nanosheets. The composite microcapsules are extremely stable in acidic (pH 2.0) and basic (pH 11.5) conditions, accompanied with pH-triggered permeability, which facilitates the controllable encapsulation and release of macromolecules. Furthermore, the graphene oxide incorporated into ultrathin LbL shells induces greatly reinforced mechanical properties, with an elastic modulus which is two orders of magnitude higher than the typical values of original silk LbL shells and shows a significant, three-fold reduction in pore size. Such strong nanocomposite microcapsules can provide solid protection of encapsulated cargo under harsh conditions, indicating a promising candidate with controllable loading/unloading for drug delivery, reinforcement, and bioengineering applications.

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Moluccensins R–Y, Limonoids from the Seeds of a Mangrove, Xylocarpus moluccensis

Cited by 40 publications

References 36 publications

Synthesis and Biological Evaluation of Novel Bischalcone Derivatives as Carbonic Anhydrase Inhibitors

Synthesis and Biological Evaluation of Novel Bischalcone Derivatives as Carbonic Anhydrase Inhibitors

Can Scientific Evidence Support Using Bangladeshi Traditional Medicinal Plants in the Treatment of Diarrhoea? A Review on Seven Plants

Robust Microcapsules with Controlled Permeability from Silk Fibroin Reinforced with Graphene Oxide

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