Molybdenum disulfide (MoS<sub>2</sub>)-based nanostructures for tissue engineering applications: prospects and challenges

Kumar, Anuj; Sood, Ankur; Han, Sung Soo

doi:10.1039/d2tb00131d

Cited by 30 publications

(10 citation statements)

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“…Appropriateness of a material for biomedical applications is substantially concluded by their extent of interaction with the biological system. A variety of organic and inorganic nanoparticles has been demonstrated to interact with biological systems which includes metal oxide, [1][2][3][4] magnetic materials, [5][6][7] noble metals, [8] polymeric particles, [9,10] miscellaneous inorganic compounds, [11][12][13] etc. Recently, a lot of emphasis has been given to piezoelectric nanomaterials, which are known to become electrically polarized under mechanical stress.…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Review on Barium Titanate Nanoparticles as a Persuasive Piezoelectric Material for Biomedical Applications: Prospects and Challenges

Sood

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Stimulation of cells with electrical cues is an imperative approach to interact with biological systems and has been exploited in clinical practices over a wide range of pathological ailments. This bioelectric interface has been extensively explored with the help of piezoelectric materials, leading to remarkable advancement in the past two decades. Among other members of this fraternity, colloidal perovskite barium titanate (BaTiO3) has gained substantial interest due to its noteworthy properties which includes high dielectric constant and excellent ferroelectric properties along with acceptable biocompatibility. Significant progression is witnessed for BaTiO3 nanoparticles (BaTiO3 NPs) as potent candidates for biomedical applications and in wearable bioelectronics, making them a promising personal healthcare platform. The current review highlights the nanostructured piezoelectric bio interface of BaTiO3 NPs in applications comprising drug delivery, tissue engineering, bioimaging, bioelectronics, and wearable devices. Particular attention has been dedicated toward the fabrication routes of BaTiO3 NPs along with different approaches for its surface modifications. This review offers a comprehensive discussion on the utility of BaTiO3 NPs as active devices rather than passive structural unit behaving as carriers for biomolecules. The employment of BaTiO3 NPs presents new scenarios and opportunity in the vast field of nanomedicines for biomedical applications.

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Section: Introductionmentioning

confidence: 99%

A Comprehensive Review on Barium Titanate Nanoparticles as a Persuasive Piezoelectric Material for Biomedical Applications: Prospects and Challenges

Sood

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Dev

et al. 2022

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“…34 The beneficial adhesion of the cells on the substrate has huge potential for stimulating cell proliferation and differentiation as well as bone regeneration. 35 In this work, the cell adhesion ratio for PM40 was the highest, followed by PM20, and that for PI was the lowest, indicating that the cell adhesion ratio on the composites improved with the increase of MD content. Cell proliferation is one of the critical factors directly related to bone regeneration.…”

Section: Discussionmentioning

confidence: 49%

Molybdenum disulfide nanosheet/polyimide composites with improved tribological performances, surface properties, antibacterial effects and osteogenesis for facilitating osseointegration

et al. 2022

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“…Two-dimensional materials such as graphene and MoS 2 are renowned for tissue engineering applications [ 179 , 180 , 181 ]. Recent years witnessed remarkable prospects for MXene in tissue engineering ( Table 6 ) owing to its structural, biological, optical, electronic, and extraordinary physicochemical properties.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Advances of MXenes; Perspectives on Biomedical Research

2022

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The last decade witnessed the emergence of a new family of 2D transition metal carbides and nitrides named MXenes, which quickly gained momentum due to their exceptional electrical, mechanical, optical, and tunable functionalities. These outstanding properties also rendered them attractive materials for biomedical and biosensing applications, including drug delivery systems, antimicrobial applications, tissue engineering, sensor probes, auxiliary agents for photothermal therapy and hyperthermia applications, etc. The hydrophilic nature of MXenes with rich surface functional groups is advantageous for biomedical applications over hydrophobic nanoparticles that may require complicated surface modifications. As an emerging 2D material with numerous phases and endless possible combinations with other 2D materials, 1D materials, nanoparticles, macromolecules, polymers, etc., MXenes opened a vast terra incognita for diverse biomedical applications. Recently, MXene research picked up the pace and resulted in a flood of literature reports with significant advancements in the biomedical field. In this context, this review will discuss the recent advancements, design principles, and working mechanisms of some interesting MXene-based biomedical applications. It also includes major progress, as well as key challenges of various types of MXenes and functional MXenes in conjugation with drug molecules, metallic nanoparticles, polymeric substrates, and other macromolecules. Finally, the future possibilities and challenges of this magnificent material are discussed in detail.

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Molybdenum disulfide (MoS₂)-based nanostructures for tissue engineering applications: prospects and challenges

Abstract: Prospects of MoS2 nanostructure-based scaffolds in tissue engineering with enhanced cellular response, immunomodulation, and antibacterial properties. An interdisciplinary and collaborative effort is crucial to perceive their clinical translation.

Cited by 30 publications

References 162 publications

A Comprehensive Review on Barium Titanate Nanoparticles as a Persuasive Piezoelectric Material for Biomedical Applications: Prospects and Challenges

A Comprehensive Review on Barium Titanate Nanoparticles as a Persuasive Piezoelectric Material for Biomedical Applications: Prospects and Challenges

Molybdenum disulfide nanosheet/polyimide composites with improved tribological performances, surface properties, antibacterial effects and osteogenesis for facilitating osseointegration

Advances of MXenes; Perspectives on Biomedical Research

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Molybdenum disulfide (MoS2)-based nanostructures for tissue engineering applications: prospects and challenges

Abstract: Prospects of MoS2 nanostructure-based scaffolds in tissue engineering with enhanced cellular response, immunomodulation, and antibacterial properties. An interdisciplinary and collaborative effort is crucial to perceive their clinical translation.

Cited by 30 publications

References 162 publications

A Comprehensive Review on Barium Titanate Nanoparticles as a Persuasive Piezoelectric Material for Biomedical Applications: Prospects and Challenges

A Comprehensive Review on Barium Titanate Nanoparticles as a Persuasive Piezoelectric Material for Biomedical Applications: Prospects and Challenges

Molybdenum disulfide nanosheet/polyimide composites with improved tribological performances, surface properties, antibacterial effects and osteogenesis for facilitating osseointegration

Advances of MXenes; Perspectives on Biomedical Research

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Molybdenum disulfide (MoS₂)-based nanostructures for tissue engineering applications: prospects and challenges