Mometasone Furoate Nasal Spray is Safe for the Treatment of Nasal Polyps in Pediatric Subjects 6-17 Years of Age

Sinus Surgery and Delivery Method Influence the Effectiveness of Topical Corticosteroids for Chronic Rhinosinusitis: Systematic Review and Meta-Analysis

“…Forty-two (87.5%) trials compared topical steroid against placebo. 17–20,22–59 Five trials (10.4%) compared topical steroid against no intervention. 60–64 One trial (2.1%) compared two different treatment regimens for steroid administration.…”

“…The steroid agents used differed across the studies. They were tixocortol pivalate, 63 fluticasone propionate, 17,19,20,22,26,36,37,41,43,48–50,53,55,56,61 betamethasone, 18,44 beclomethasone dipropionate, 26,43,48,51,52,60,62,65 mometasone furoate, 27–30,38,45,54 budesonide, 23–25,31–35,39,42,57,58,64 flunisolide, 46,47 triamcinolone acetonide, 59 and dexamethasone. 40…”

“…Thirty trials delivered the topical steroid via a nasal spray, 17,22–24,26–30,32,34–38,40,41,43,45–48,51,54,56–58,60,61,65 seven trials used nasal drops, 19,20,44,49,50,53,55 one trial instilled the drug through an intranasal tube, 18 five trials used aerosol, 24,33,42,52,59 three trials used turbuhaler, 25,31,58 and one study 62 used the term “intranasal” without clearly stating the delivery method used.…”

“…For 27 trials (56.3%), 17,19,20,26,30,33,34,[37][38][39]43,[46][47][48]50,[52][53][54][55][56][57][58][59][60][61][62]64 patients (all or the majority) had sinus surgery before administering steroid either as a coint-ervention or they had previous surgery documented. In 15 (31.3%) studies, 18,[22][23][24][25][27][28][29]31,35,36,44,45,49,51 patients (all or the majority) had no previous sinus surgery. Mixed populations of patients with an undefined proportion having previous surgeries were presented in six trials (12.5%).…”

“…40 Three trials used a direct sinus delivery technique whereby the drug was instilled directly into the sinus through a sinusotomy tube in one study, 39 intrasinus lavage in one study, 63 and postoperative nasal irrigation in one study. 64 Thirty trials delivered the topical steroid via a nasal spray, 17,[22][23][24][26][27][28][29][30]32,[34][35][36][37][38]40,41,43,[45][46][47][48]51,54,[56][57][58]60,61,65 seven trials used nasal drops, 19,20,44,49,50,53,55 one trial instilled the drug through an intranasal tube, 18 five trials used aerosol, 24,33,42,52,59 three trials used turbuhaler, 25,…”