Mometasone furoate nasal spray reduces the ocular symptoms of seasonal allergic rhinitis

Prenner, Bruce M.; Lanier, Bob; Bernstein, David I.; Shekar, Tulin; Teper, Ariel

doi:10.1016/j.jaci.2010.03.004

Cited by 28 publications

(26 citation statements)

References 64 publications

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“…There was a significant reduction intotal ocular symptom score and total nasal symptom score in these study groups when compared to placebo group (P < .001) [25,26].…”

Section: Intranasal Corticosteroidsmentioning

confidence: 76%

An Evidence Based Review on the Current Medical Management of Allergic Rhinitis

Munonyara¹,

Mohammed²

2012

J Aller Ther

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“…There was a significant reduction intotal ocular symptom score and total nasal symptom score in these study groups when compared to placebo group (P < .001) [25,26].…”

Section: Intranasal Corticosteroidsmentioning

confidence: 76%

An Evidence Based Review on the Current Medical Management of Allergic Rhinitis

Munonyara¹,

Mohammed²

2012

J Aller Ther

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“…MFNS was associated with a significant reduction in total nasal symptom scores (standardized mean difference (SMD), −0.49; 95% confidence interval (CI), −0.60 to −0.38; P<0.00001), total nonnasal symptom scores (−0.30; 95% CI, −0.43 to −0.18; P<0.00001), and rhinorrhea (SMD, −0.44; 95% CI, −0.66 to −0.21; P=0.0001), as well as the other individual nasal symptoms evaluated [46]. Specifically with regard to rhinorrhea, a number of individual clinical trials, as well as several meta-analyses, support the efficacy of INS for relief of this particularly bothersome AR symptom (Table 4) [46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62].…”

Section: Clinical Efficacy Of Ins For Rhinorrhea In Armentioning

confidence: 88%

Intranasal Steroids in the Treatment of Allergy-Induced Rhinorrhea

Nathan¹

2010

Clinic Rev Allerg Immunol

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While nasal congestion has been identified as one of the most bothersome and prevalent symptoms of allergic rhinitis, it is underappreciated that many patients find rhinorrhea also to be bothersome. Rhinorrhea as a symptom of allergic rhinitis virtually never occurs alone; about 97% of patients with allergic rhinitis suffer from at least two symptoms, a finding that underscores the advantage of treating a broad range of symptoms with a single medication. Along with sneezing and nasal obstruction, rhinorrhea is a classic acute symptom of allergic rhinitis; it appears as a late-phase symptom as well. In this review, the characterization and epidemiology of rhinorrhea, the pathophysiology of rhinorrhea in allergic rhinitis, the roles played by mediators in early- and late-phase rhinorrhea, the prevalence and impact of this symptom, and the efficacy and safety of available treatment options are all discussed in context of relevant literature. A review of the clinical studies assessing the efficacy of intranasal corticosteroids (INS) for rhinorrhea is presented. Many clinical studies and several meta-analyses conclusively demonstrate that, in addition to being safe and well-tolerated, INS are more effective than other agents (including oral and intranasal antihistamines) across the spectrum of AR symptoms, including rhinorrhea and nasal congestion.

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“…Individuals with both nasal and ocular symptoms may benefit from INSs treatment. Indeed, recent clinical trial evidence in adults showed that INSs provided relief from the ocular symptoms of SAR/SAC [20,21,84,85,86,87]. However, few INSs have demonstrated this effect consistently in well-controlled clinical studies.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence obtained more recently increasingly suggests that INSs may be effective in alleviating ocular symptoms (e.g. eye watering) [18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35]. …”

Section: Introductionmentioning

confidence: 99%

“…The favorable effect of INSs on ocular symptoms [44] was supported by recent studies which included treatment with INSs agents: mometasone furoate (MF) [18,19,20,21], fluticasone furoate (FF) [22,23,24,25,26,27,28], fluticasone propionate (FP) [29,30], budesonide [31], and (to some degree) triamcinolone acetonide (TA) [32] and beclomethasone dipropionate (BDP) aqueous nasal spray [33,34]. However, the effects of INSs on ocular symptoms were inconsistent across some separate studies [37,40].…”

Section: Introductionmentioning

confidence: 99%

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Should Intranasal Corticosteroids Be Used for the Treatment of Ocular Symptoms of Allergic Rhinoconjunctivitis? A Review of Their Efficacy and Safety Profile

Lightman

Scadding²

2012

Int Arch Allergy Immunol

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Allergic rhinoconjunctivitis (ARC) presents as nasal symptoms, eye watering and additional signs of ocular allergy (e.g. itchy/burning eyes). Intranasal corticosteroids (INSs) are the most effective treatment for the nasal symptoms of seasonal allergic rhinitis (SAR; based on 4 meta-analyses) and are considered first-line therapy when nasal congestion forms a substantial component of the patient’s rhinitis symptoms. Clinical trial evidence shows that INSs also provide some relief from ocular symptoms of SAR and seasonal ARC in adults. INSs probably alleviate eye watering, the main ocular symptom of SAR, by relieving nasal congestion. Other ocular symptoms also improve with INSs. The mechanism for this effect is unknown, but might relate to naso-ocular reflex reduction. There are limited data on ocular safety with INSs. However, the literature supports the use of INSs over several months as there appears to be no considerable increase in the risk of ocular hypertension or glaucoma.

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Mometasone furoate nasal spray reduces the ocular symptoms of seasonal allergic rhinitis

Cited by 28 publications

References 64 publications

An Evidence Based Review on the Current Medical Management of Allergic Rhinitis

An Evidence Based Review on the Current Medical Management of Allergic Rhinitis

Intranasal Steroids in the Treatment of Allergy-Induced Rhinorrhea

Should Intranasal Corticosteroids Be Used for the Treatment of Ocular Symptoms of Allergic Rhinoconjunctivitis? A Review of Their Efficacy and Safety Profile

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