Momordica charantia Extract Confers Protection Against Hypertension in Dahl Salt-Sensitive Rats

Zeng, Li; Chen, Meng; Ahmad, Hussain; Zheng, Xiaodong; Ouyang, Yanan; Yang, Pengfei; Yang, Zhe; Gao, Di; Tian, Zhongmin

doi:10.1007/s11130-022-00971-6

Cited by 4 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…That the plants are, nevertheless, used against HF may be due to their potential to relieve the cardiac workload [6]. Indeed, previous studies reported that an aqueous extract from A. muricata fruit displayed ACE inhibitory activity and blood pressure-lowering effects in vitro [33]; preparations from M. charantia leaf, whole plant, and seed extracts lowered blood pressure in laboratory rats [34][35][36]; and those from C. cainito fruit pulp and leaf elicited antihypertensive activity in isolated rat aortic rings and salt-induced hypertensive rats [37][38][39]. In addition, A. muricata leaf extracts relaxed blood vessels and decreased blood pressure in both normotensive and hypertensive laboratory rats, presumably by blocking calcium ion channels [40,41].…”

Section: Discussionmentioning

confidence: 99%

Effects of plants with presumed cardiotonic properties on the decreased contractility of isolated guinea pig atria caused by acetylcholine: Implications for their clinical usefulness

Dennis R.A. Mans,

Rouafsa F. Joemmanbaks,

Walther Jap Tjoen San

2024

World J. Bio. Pharm. Health Sci.

View full text Add to dashboard Cite

Heart failure (HF) has been related to a chronic imbalance between autonomic sympathetic and parasympathetic activation. In the Republic of Suriname (South America), this condition is regularly treated with plant-derived preparations with presumed cardiotonic properties, mostly by traditional healers. In this study, aqueous extracts from Annona muricata (leaf), Mansoa alliacea (leaf), Momordica charantia (leaf and stem), Gossypium barbadensis (leaf), Artocarpus altilis (leaf), Chrysophyllum cainito (leaf), Solanum melongena (unripe fruit), and Stachytarpheta jamaicensis (leaf and stem) were evaluated at serial dilutions for their capability to reverse the decreased contractility and for their effects on the decreased beating frequency of isolated guinea pig atria caused by EC50 acetylcholine (10-7 M). The effects of the plant extracts alone were also investigated. Experiments were for 3 min with 2 x 2-min intervals in Ringer-Locke buffer, 100% O2, and 30 °C. Results (g/sec and beats/min, means ± SDs; n ≥ 3) were expressed relative to those found with acetylcholine alone or buffer alone, and compared for statistically significant differences using one-way ANOVA (p < 0.05). None of the extracts reversed the decreased contractility and beating frequency of the atria caused by acetylcholine, but those from M. alliacea (0.001 mg/mL) and S. melongena (0.001 and 0.01 mg/mL) lowered these activities by more than 50%. The latter extracts exerted similar effects on their own. Thus, the preparations did not display useful cardiotonic properties against parasympathetic abnormalities in HF, and those from M. alliacea and S. melongena might even be cardiotoxic, warranting care when they are medicinally used.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of plants with presumed cardiotonic properties on the decreased contractility of isolated guinea pig atria caused by acetylcholine: Implications for their clinical usefulness

Dennis R.A. Mans,

Rouafsa F. Joemmanbaks,

Walther Jap Tjoen San

2024

World J. Bio. Pharm. Health Sci.

View full text Add to dashboard Cite

show abstract

Extraction methods, multiple biological activities, and related mechanisms of Momordica charantia polysaccharide: A review

Liu,

Guo,

Sun

et al. 2024

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Recent advances of traditional Chinese medicine against cardiovascular disease: overview and potential mechanisms

Dai,

Qiu,

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

Cardiovascular disease (CVD) is the leading cause of human mortality worldwide. Despite Western medicine having made encouraging results in the clinical management of CVD, the morbidity, mortality, and disability rates of the disease remain high. Modern pharmacology has confirmed that traditional Chinese medicine (TCM), characterized by its multi-component, multi-target, and integrity, plays a positive and important role in the prevention and treatment of various CVDs in China, which has notable advantages in stabilizing disease, improving heart function, and enhancing the quality of life. Importantly, TCM is gradually being accepted by the international community due to its low cost, high safety, versatile bioactivity, and low toxicity. Unfortunately, comprehensive studies on the therapeutic effect of TCM on CVD and its mechanisms are very limited, which may restrict the clinical application of TCM in CVD. Therefore, this review is performed to analyze the pathogenesis of CVD, including inflammatory response, oxidative stress, mitochondrial dysfunction, pyroptosis, ferroptosis, dysbiosis of gut microbiota, etc. Moreover, we summarized the latest progress of TCM (formulas, extracts, and compounds) in curing CVD according to published literature from 2018 to 2023, as well as its mechanisms and clinical evidence. In conclusion, this review is expected to provide useful information and reference for the clinical application of TCM in the prevention and treatment of CVD and further drug development of CVD.

show abstract

Momordica charantia Extract Confers Protection Against Hypertension in Dahl Salt-Sensitive Rats

Cited by 4 publications

References 28 publications

Effects of plants with presumed cardiotonic properties on the decreased contractility of isolated guinea pig atria caused by acetylcholine: Implications for their clinical usefulness

Effects of plants with presumed cardiotonic properties on the decreased contractility of isolated guinea pig atria caused by acetylcholine: Implications for their clinical usefulness

Extraction methods, multiple biological activities, and related mechanisms of Momordica charantia polysaccharide: A review

Recent advances of traditional Chinese medicine against cardiovascular disease: overview and potential mechanisms

Contact Info

Product

Resources

About