Momordica charantia polysaccharide ameliorates D-galactose-induced aging through the Nrf2/β-Catenin signaling pathway

Yue, Jun; Guo, Peng; Jin, Yang; Li, Ming; Wang, Wan; Wei, Xuewen; Qi, Suhua

doi:10.1007/s11011-022-01103-4

Cited by 12 publications

(5 citation statements)

References 50 publications

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“…The acetone fraction of fruit juice can also decrease NLRP3 expression in RAW264.7 [137], which is in agreement with the observations of Nerurkar et al in mice [138]. In addition, pawoka polysaccharides improve antioxidant capacity by decreasing the level of malondialdehyde and increasing the expression of antioxidant enzymes such as superoxide dismutase and glutathione via enhancing the entry of Nrf2 into the nuclei of hypothalamus cells in a D-galactose induced aging rat model [139].…”

Section: Momordica Charantia L 1753supporting

confidence: 89%

Antioxidant Activities of Natural Compounds from Caribbean Plants to Enhance Diabetic Wound Healing

Accipe,

Abadie,

Neviere

et al. 2023

Antioxidants

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Diabetic wound healing is a global medical challenge. Several studies showed that delayed healing in diabetic patients is multifactorial. Nevertheless, there is evidence that excessive production of ROS and impaired ROS detoxification in diabetes are the main cause of chronic wounds. Indeed, increased ROS promotes the expression and activity of metalloproteinase, resulting in a high proteolytic state in the wound with significant destruction of the extracellular matrix, which leads to a stop in the repair process. In addition, ROS accumulation increases NLRP3 inflammasome activation and macrophage hyperpolarization in the M1 pro-inflammatory phenotype. Oxidative stress increases the activation of NETosis. This leads to an elevated pro-inflammatory state in the wound and prevents the resolution of inflammation, an essential step for wound healing. The use of medicinal plants and natural compounds can improve diabetic wound healing by directly targeting oxidative stress and the transcription factor Nrf2 involved in the antioxidant response or the mechanisms impacted by the elevation of ROS such as NLRP3 inflammasome, the polarization of macrophages, and expression or activation of metalloproteinases. This study of the diabetic pro-healing activity of nine plants found in the Caribbean highlights, more particularly, the role of five polyphenolic compounds. At the end of this review, research perspectives are presented.

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Section: Momordica Charantia L 1753supporting

confidence: 89%

Antioxidant Activities of Natural Compounds from Caribbean Plants to Enhance Diabetic Wound Healing

Accipe,

Abadie,

Neviere

et al. 2023

Antioxidants

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show abstract

“…One study did not report the route of administration [ 11 ]. Eighteen studies tested the dose of herbal medicine at a single concentration [ 11 , 13 , 17 , 18 , 19 , 20 , 21 , 24 , 28 , 31 , 37 , 38 , 39 , 40 , 42 , 46 , 48 , 50 ], and in 21 studies, 2 or 3 types of concentrations were tested [ 8 , 9 , 10 , 14 , 15 , 16 , 22 , 23 , 25 , 26 , 27 , 29 , 30 , 32 , 33 , 34 , 35 , 36 , 41 , 45 , 47 ]. The other two studies did not report the dosage used [ 12 , 44 ].…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of In Vivo Studies of the Efficacy of Herbal Medicines for Anti-Aging in the Last Five Years

et al. 2023

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Background: The world’s population is rapidly aging, and attention to and research on the increase in life expectancy and age-related diseases are needed. This study aimed to review the in vivo studies on the anti-aging effects of herbal medicines. Methods: In vivo studies of single or complex herbal medicines for anti-aging that were published in the last five years were included in this review. The following databases were used: PubMed, Scopus, ScienceDirect, Web of Science and EMBASE. Results: A total of 41 studies were considered eligible for the review. The articles were classified into body organs and functions, experimental country, herbal medicine, extraction method, administration route, dosage, duration, animal model, aging-induced method, sex, number of animals per group, and outcomes and mechanisms A single herbal extract was used in a total of 21 studies including Alpinia oxyphylla Miq., Acanthopanax senticosus and Lyceum barbarum, and a multi-compound herbal prescription was used in a total of 20 studies, including Modified Qiongyu paste, Wuzi Yanzong recipe, etc. Each herbal medicine had anti-aging effects on learning and memory, cognition, emotion, internal organs, gastrointestinal tracts, sexual functions, musculoskeletal function and so on. The common mechanisms of action were antioxidant and anti-inflammatory, and various effects and mechanisms for each organ and function were identified. Conclusions: Herbal medicine exhibited beneficial effects on anti-aging in various parts of the body and its function. Further investigation of the appropriate herbal medicine prescriptions and their components is recommended.

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“…Neuroprotective activities of bioactive metabolites from MC have been reported especially those of polysaccharides. 30,34,35,39,54,57,58 Other neuroprotective metabolites include protocatechuic acid, 28,45,55 charantin 52 and α-eleostearic acid. 38 Their chemical structures are described below.…”

Section: Neuroprotective Metabolitesmentioning

confidence: 99%

A Mini-Review on the Neuroprotective Effects of Extracts and Metabolites of Momordica charantia

2024

TJNPR

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This mini-review is on the neuroprotective effects of Momordica charantia (MC), a climbing cucurbit better well-known for its anti-diabetic and anti-cancer properties. Commonly known as bitter gourd or bitter melon, MC is a belongs to the family Curcubitaceae. Bitter gourd is rich in bioactive chemical constituents such as polysaccharides, cucurbitane triterpenoids, triterpene glycosides, phenolic acids, flavonoids, essential oils, saponins, fatty acids and proteins. The neuroprotective activities of MC extracts and metabolites can be categorized into different nervous system disorders as targets. They are central nervous system injury, neuronal damage, defective memory, neuronal cancer, neuro-inflammation, cognitive impairment and aging. Studies on the neuroprotective activities of MC juice, extracts, fractions, essential oil and metabolites are based on models of induced brain, cerebral ischemic/reperfusion and neuronal injury. Neuroprotective studies on MC are also based on models of induced neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Research on neurological cancer cells include studies on neuroblastoma and glioma cells. Bioactive metabolites with neuroprotective activities include polysaccharides, protocatechuic acid, charantin and α-eleostearic acid. Aspects for further research are suggested.

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Momordica charantia polysaccharide ameliorates D-galactose-induced aging through the Nrf2/β-Catenin signaling pathway

Cited by 12 publications

References 50 publications

Antioxidant Activities of Natural Compounds from Caribbean Plants to Enhance Diabetic Wound Healing

Antioxidant Activities of Natural Compounds from Caribbean Plants to Enhance Diabetic Wound Healing

A Systematic Review of In Vivo Studies of the Efficacy of Herbal Medicines for Anti-Aging in the Last Five Years

A Mini-Review on the Neuroprotective Effects of Extracts and Metabolites of Momordica charantia

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