MOMS technology for fully fiber optic ultrasonic probes: A proposal for virtual biopsy

Biagi, E.; Cerbai, S.; Masotti, L.; Belsito, Luca; Roncaglia, Alessandro; Masetti, G.; Speciale, N.

doi:10.1109/icsens.2010.5690824

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…Similar to the axial resolution, good lateral resolution values was achieved in this study, with values as low as

150

µm. These values were comparable to a typical commercial ultrasound device which can achieve lateral resolutions of

200

µm depending on the bandwidth and frequency of the device [ 2 , 34 , 35 ], as well as being comparable to previously reported OpUS transducers [ 1 , 3 , 13 ]. Unlike the axial resolution, the lateral resolution showed dependence on various imaging parameters.…”

Section: Discussionsupporting

confidence: 86%

“…However, this methodology is at significant risk of sampling error; the likelihood of positive identification of Barrett’s Oesophagus is shown to correlate with the number of biopsies acquired [ 26 , 27 ]. The addition of OpUS imaging through this working channel might be used to provide a ’virtual biopsy’ [ 13 , 28 ] of the current stage of the disorder in real-time, as well as providing potential guidance for biopsy.…”

Section: Introductionmentioning

confidence: 99%

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All-optical ultrasound catheter for rapid B-mode oesophageal imaging

Lewis‐Thompson¹,

Zhang²,

Beard³

et al. 2023

Biomed. Opt. Express

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All-optical ultrasound (OpUS) is an imaging paradigm that uses light to both generate and receive ultrasound, and has progressed from benchtop to in vivo studies in recent years, demonstrating promise for minimally invasive surgical applications. In this work, we present a rapid pullback imaging catheter for side-viewing B-mode ultrasound imaging within the upper gastrointestinal tract. The device comprised an ultrasound transmitter configured to generate ultrasound laterally from the catheter and a plano-concave microresonator for ultrasound reception. This imaging probe was capable of generating ultrasound pressures in excess of 1 MPa with corresponding −6 dB bandwidths > 20 MHz. This enabled imaging resolutions as low as 45 µm and 120 µm in the axial and lateral extent respectively, with a corresponding signal-to-noise ratio (SNR) of 42 dB. To demonstrate the potential of the device for clinical imaging, an ex vivo swine oesophagus was imaged using the working channel of a mock endoscope for device delivery. The full thickness of the oesophagus was resolved and several tissue layers were present in the resulting ultrasound images. This work demonstrates the promise for OpUS to provide rapid diagnostics and guidance alongside conventional endoscopy.

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“…Similar to the axial resolution, good lateral resolution values was achieved in this study, with values as low as

150

µm. These values were comparable to a typical commercial ultrasound device which can achieve lateral resolutions of

200

Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

All-optical ultrasound catheter for rapid B-mode oesophageal imaging

Lewis‐Thompson¹,

Zhang²,

Beard³

et al. 2023

Biomed. Opt. Express

View full text Add to dashboard Cite

show abstract

“…A small coating thickness can be important to minimize acoustic attenuation within nanocomposite materials ( 10 ). To this end, several methods have been explored for depositing nanocomposite materials onto the distal surface of the fiber optic transducer, including spin-coating ( 17 ), electrospinning ( 18 ), and dip-coating ( 15 ). With the latter method, a “bottom up” approach typically involves coating the substrate with an optical absorber and a subsequent polymer overcoat (for instance, PDMS).…”

Section: Introductionmentioning

confidence: 99%

Optically Generated Ultrasound for Intracoronary Imaging

Little

Colchester

Noimark

et al. 2020

Front. Cardiovasc. Med.

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Conventional intravascular ultrasound (IVUS) devices use piezoelectric transducers to electrically generate and receive US. With this paradigm, there are numerous challenges that restrict improvements in image quality. First, with miniaturization of the transducers to reduce device size, it can be challenging to achieve the sensitivities and bandwidths required for large tissue penetration depths and high spatial resolution. Second, complexities associated with manufacturing miniaturized electronic transducers can have significant cost implications. Third, with increasing interest in molecular characterization of tissue in-vivo , it has been challenging to incorporate optical elements for multimodality imaging with photoacoustics (PA) or near-infrared spectroscopy (NIRS) whilst maintaining the lateral dimensions suitable for intracoronary imaging. Optical Ultrasound (OpUS) is a new paradigm for intracoronary imaging. US is generated at the surface of a fiber optic transducer via the photoacoustic effect. Pulsed or modulated light is absorbed in an engineered coating on the fiber surface and converted to thermal energy. The subsequent temperature rise leads to a pressure rise within the coating, which results in a propagating ultrasound wave. US reflections from imaged structures are received with optical interferometry. With OpUS, high bandwidths (31.5 MHz) and pressures (21.5 MPa) have enabled imaging with axial resolutions better than 50 μm and at depths >20 mm. These values challenge those of conventional 40 MHz IVUS technology and show great potential for future clinical application. Recently developed nanocomposite coating materials, that are highly transmissive at light wavelengths used for PA and NIRS light, can facilitate multimodality imaging, thereby enabling molecular characterization.

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MOMS technology for fully fiber optic ultrasonic probes: A proposal for virtual biopsy

Cited by 2 publications

References 6 publications

All-optical ultrasound catheter for rapid B-mode oesophageal imaging

All-optical ultrasound catheter for rapid B-mode oesophageal imaging

Optically Generated Ultrasound for Intracoronary Imaging

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