Mon-267 Relationship Between Liver Fibrosis and Chronic Kidney Disease in Non-Alcoholic Fatty Liver Disease Subjects

Ramadhan, Z.; Rasyid, Haerani; Bakri, Syakib; Kasim, Hasyim; Parewangi, Muhammad Luthfi; Akil, Fardah; Seweng, Arifin

doi:10.1016/j.ekir.2019.05.1071

Cited by 1 publication

(2 citation statements)

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“…Ramadhan et al . 58 found that the presence of liver fibrosis increased the CKD risk by approximately 3.8 times in patients with NAFLD (95% CI: 1.07–13.79, p =0.035); meanwhile, the frequency of grades 2 and 3 CKD was higher in patients with liver fibrosis than in those without ( p =0.034). Kasim et al .…”

Section: Effects Of Nafld On Ckd Severitymentioning

confidence: 97%

“…A meta-analysis of 33 studies also showed that the presence of steatohepatitis (odds ratio [OR]=2.53, 95% CI: 1.58-4.05) and advanced fibrosis (OR=5.20, 95% CI: 3.14-8.61) increased the risk of CKD, and a positive correlation was also found between NAFLD severity and CKD stages. 34 Ramadhan et al 58 found that the presence of liver fibrosis increased the CKD risk by approximately 3.8 times in patients with NAFLD (95% CI: 1.07-13.79, p=0.035); meanwhile, the frequency of grades 2 and 3 CKD was higher in patients with liver fibrosis than in those without (p=0.034). Kasim et al 35 also found more grade 3 CKD patients in the NAFLD group than in the control group (37.3% vs. 9.0%).…”

Section: Effects Of Nafld On Ckd Severitymentioning

confidence: 99%

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Influence of Nonalcoholic Fatty Liver Disease on the Occurrence and Severity of Chronic Kidney Disease

Tao¹,

Li²,

Cheng³

et al. 2021

J Clin Transl Hepatol

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Nonalcoholic fatty liver disease (NAFLD) is reported to affect 20-30% of adults and is accompanied by various metabolic comorbidities, where the economic and clinical burden of NAFLD is attributed to the progression of liver disease as well as the presence of extrahepatic diseases. Chronic kidney disease (CKD), which has a high incidence rate, high morbidity and mortality rates, and high medical costs, has been linked to NAFLD. CKD is associated with some metabolism-related risk factors that overlap with metabolic comorbidities of NAFLD. Therefore, to investigate the potential factors that influence CKD occurrence, the association between NAFLD and CKD should be clarified. Some studies have confirmed that NAFLD influences the occurrence and severity of CKD, whereas some studies have indicated that there is no correlation. In this review, the results of a few studies have been discussed, the potential risk factors for CKD in NAFLD are explored, and the respective biological mechanisms are elaborated to help clinicians identify CKD in patients much earlier than it is diagnosed now and thus help in reducing the incidence of liver and kidney transplants.

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Section: Effects Of Nafld On Ckd Severitymentioning

confidence: 97%