MON-PO460: Accute Effects of Diet in Older Adults with a Risk Phenotype for Neurodegenerative Diseases Using Neurofilament Light: A Proof of Concept

Becks, S.; Schönknecht, Yannik Bernd; Göpfert, Jens; Fimmers, R.; Stehle, P.; Simon, Marie‐Christine; Egert, Sarah

doi:10.1016/s0261-5614(19)32293-9

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“…Since we were able to show that protein concentrations changed already in the very early postprandial phase, it is likely that the acute postprandial phase was not reflected. In contrast to this and in line with our findings, in a pilot study, serum NfL levels decreased after food intake and increased again after 120 min 36 . Also CSF levels of metabolites associated with brain‐related diseases were reported to be putatively affected by food intake 37 .…”

Section: Discussionsupporting

confidence: 84%

“…In contrast to this and in line with our findings, in a pilot study, serum NfL levels decreased after food intake and increased again after 120 min. 36 Also CSF levels of metabolites associated with brain-related diseases were reported to be putatively affected by food intake. 37 Moreover, the intake of a protein-rich beverage 38 and an oral glucose load 39 led to increases in amyloid precursor protein (APP), Aβ40, and Aβ42 plasma levels in healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

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Levels of Alzheimer's disease blood biomarkers are altered after food intake—A pilot intervention study in healthy adults

Huber,

Ashton,

Schieren

et al. 2023

Alzheimer's & Dementia

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INTRODUCTIONBlood biomarkers accurately identify Alzheimer's disease (AD) pathophysiology and axonal injury. We investigated the influence of food intake on AD‐related biomarkers in cognitively healthy, obese adults at high metabolic risk.METHODSOne‐hundred eleven participants underwent repeated blood sampling during 3 h after a standardized meal (postprandial group, PG). For comparison, blood was sampled from a fasting subgroup over 3 h (fasting group, FG). Plasma neurofilament light (NfL), glial fibrillary acidic protein (GFAP), amyloid‐beta (Aβ) 42/40, phosphorylated tau (p‐tau) 181 and 231, and total‐tau were measured via single molecule array assays.RESULTSSignificant differences were found for NfL, GFAP, Aβ42/40, p‐tau181, and p‐tau231 between FG and PG. The greatest change to baseline occurred for GFAP and p‐tau181 (120 min postprandially, p < 0.0001).CONCLUSIONOur data suggest that AD‐related biomarkers are altered by food intake. Further studies are needed to verify whether blood biomarker sampling should be performed in the fasting state.Highlights Acute food intake alters plasma biomarkers of Alzheimer's disease in obese, otherwise healthy adults. We also found dynamic fluctuations in plasma biomarkers concentration in the fasting state suggesting physiological diurnal variations. Further investigations are highly needed to verify if biomarker measurements should be performed in the fasting state and at a standardized time of day to improve the diagnostic accuracy.

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Section: Discussionsupporting

confidence: 84%