Monckeberg's sclerosis in temporal artery biopsy specimens

Castillo, Bienvenido V.; Torczynski, Elise; Edward, Deepak P.

doi:10.1136/bjo.83.9.e1088

Cited by 28 publications

(11 citation statements)

References 4 publications

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“…They found that 39 % of them had focal calcifications, opposite to Castillo et al that only found 6 % [6]. To a lesser extent, calcifications of elastic intima may also be found in older normal arteries (aterosclerosis).…”

Section: Commentscontrasting

confidence: 38%

Calciphylaxis of the temporal artery masquerading as temporal arteritis: a case presentation and review of the literature

Roverano¹,

Ortiz²,

Henares³

et al. 2015

Clin Rheumatol

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An 82-year-old woman came to consultation with sudden visual loss in her left eye. Fifteen days before, she complained of diplopia. She had doubtful symptoms of giant cell arteritis and showed a normal physical exam. Lab results showed erythrosedimentation rate (ESR) = 62 mm/1°h; uremia = 0.56 g/dl (normal <0.45); serum creatinine = 1.7 mg% (normal <1.4); low calcium and phosphorus; and normal urine calcium and serous PTH. Fundus exam and brain magnetic resonance imaging (MRI) showed normality of optic nerves, chiasma, retrochiasmatic area, ocular muscles, eyeballs, lacrimal glands, periorbital fat, cavernous sinuses, and occipital cortex. A temporal arteritis was suspected; therefore, a biopsy was carried on. It showed the presence of large calcium deposits in the artery's tunica media and internal elastic lamina, with narrowing of the lumen, with no inflammation and multinuclear giant cells. Histological diagnosis is calciphylaxis. Although calciphylaxis is a well-described entity that occurs in end-stage renal patients, many cases are due to non-uremic causes. To date, there are only six cases described in literature of calciphylaxis mimicking GCA.

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Section: Commentscontrasting

confidence: 38%

Calciphylaxis of the temporal artery masquerading as temporal arteritis: a case presentation and review of the literature

Roverano¹,

Ortiz²,

Henares³

et al. 2015

Clin Rheumatol

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“…The infiltrate is essentially composed of mononuclear cells and includes epithelioid histiocytes and occasionally giant cells. Calcification may be focally present and is often secondary to atherosclerosis, hence the term ‘calcific uremic arteriolopathy’ 4 . Although the symptoms and signs manifested by the patient were suggestive of temporal arteritis, histopathology revealed only minimal inflammation and extensive medial arterial calcification, a combination of findings that is consistent with calciphylaxis.…”

Section: Discussionmentioning

confidence: 90%

Calciphylaxis of the temporal artery masquerading as temporal arteritis

Awwad¹,

Ghosn²,

Hogan³

2010

Clinical Exper Ophthalmology

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We describe a case of a 75-year-old man with diabetes type II and end-stage renal disease, presenting with a one-month history of blurring of vision in the left eye. Fundus exam showed pale and swollen optic nerve in the left eye, and temporal artery biopsy showed diffuse and extensive calcification at the internal elastic lamina and media. Biopsy of dusky erythematous lesions over the calves revealed the diagnosis of calciphylaxis. The temporal artery calcific lesions should hence be differentiated from the less extensive atherosclerotic changes, which mainly affect the media of the artery, as it is crucial to suspect this life-threatening diagnosis in patients at risk.

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“…Vascular media calcification, also named arteriosclerosis, or Mönckebergs' sclerosis, is characterized by concentric calcifications in the tunica media of large elastic arteries, medium-sized visceral and renal arteries, as well as in small transitional arteries [69][70][71]. The principal consequences are increased wall thickness, arterial stiffening and development of left ventricular hypertrophy.…”

Section: Vascular Calcificationmentioning

confidence: 99%

The Role of Sclerostin in Bone and Ectopic Calcification

Maré

D’Haese

Verhulst

2020

IJMS

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Sclerostin, a 22-kDa glycoprotein that is mainly secreted by the osteocytes, is a soluble inhibitor of canonical Wnt signaling. Therefore, when present at increased concentrations, it leads to an increased bone resorption and decreased bone formation. Serum sclerostin levels are known to be increased in the elderly and in patients with chronic kidney disease. In these patient populations, there is a high incidence of ectopic cardiovascular calcification. These calcifications are strongly associated with cardiovascular morbidity and mortality. Although data are still controversial, it is likely that there is a link between ectopic calcification and serum sclerostin levels. The main question, however, remains whether sclerostin exerts either a protective or deleterious role in the ectopic calcification process.

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Monckeberg's sclerosis in temporal artery biopsy specimens

Cited by 28 publications

References 4 publications

Calciphylaxis of the temporal artery masquerading as temporal arteritis: a case presentation and review of the literature

Calciphylaxis of the temporal artery masquerading as temporal arteritis: a case presentation and review of the literature

Calciphylaxis of the temporal artery masquerading as temporal arteritis

The Role of Sclerostin in Bone and Ectopic Calcification

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