2024
DOI: 10.1007/s10753-024-02090-7
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Monensin Suppresses Multiple Features of House Dust Mite-Induced Experimental Asthma in Mice

Venkata Sita Rama Raju Allam,
Srinivas Akula,
Ida Waern
et al.

Abstract: Despite intense efforts to develop efficient therapeutic regimes for asthma, there is a large demand for novel treatment strategies in this disease. Here we evaluated the impact of monensin, a drug with potent anti-mast cell effects, in a mouse model of asthma. Allergic airway inflammation was induced by sensitization of mice with house dust mite (HDM) antigen, and effects of monensin on airway hyperreactivity and inflammatory parameters were studied. Following intraperitoneal administration, monensin did not … Show more

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