A railway bridge has been the object of investigation in the context of structural health monitoring (SHM). The current work is focused on utilization of experimental data for refining a numerical model of the structure as well as on tests of dynamic excitations using a controlled hydraulic shaker and passing trains. The numerical model has been matched to experimental measurements using experimental modal analysis - classical and operational. The tailored SHM system for monitoring of the bridge consists of 15 piezoelectric strain sensors taking advantage of wireless communication for data transfer. Experimental responses of the bridge collected by the SHM system are confronted with the ones produced by the FE numerical model of the bridge. The long-term objective of the investigation is to elaborate a method for assessment of structural condition and prediction of remaining lifetime of the bridge.