Antimony (Sb) is a trace element applied widely in modern industry. A large number of tailing solid wastes are left and accumulated in the mining area after purifying the precious antimony from the antimony ores, causing serious pollution to the environment. The major aim of this study is to investigate the feasibility of utilizing antimony tailing coarse aggregate (ATCA) as a complete substitute for natural coarse aggregate (NCA) in high-strength concrete. Concrete specimens with 25%, 50%, 75%, and 100% ATCA replacing the NCA in conventional concrete were prepared for evaluating the performance of ATCA concrete. The investigators find that ATCA concrete has good workability, and the mechanical properties and long-term behavior (shrinkage and creep) of ATCA concrete with all replacement levels are superior to those of NCA concrete. The durability indices of ATCA concrete, such as the frost-resistant, chloride permeability, and resistance to carbonation, are better than those of NCA concrete. While the alkali activity and cracking sensitivity behavior of ATCA concrete seem to be decreased, nevertheless, the difference is not significant and can be neglected. The researchers demonstrate that all of the control indices of ATCA concrete meet the requirements of the current industry standards of China. Overall, ATCA can be used in concrete to minimize environmental problems and natural resources depletion.