The article analyzes the levels of organic ecotoxicants, specifically organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), in the surface waters of the Dnieper River and other global water systems, highlighting trends over recent decades. The levels of OCPs and PCBs in the Dnieper River remained stable, with slight increases observed between 1994 and 2021. The average total concentrations during this period were 12.19±4.73 ng/dm³ (OCPs) and 23.13±20.64 ng/dm³ (PCBs). In other regions, average OCP concentrations (ng/ dm³) were: 5.7±1.8 (Italy), 1.77±0.56 (Tyrrhenian Sea), 318 (Ganga River), 21.3 (Yangtze River), 34.4 (Huai River), and 69.9 (Pearl River Delta). For PCBs, the respective concentrations (ng/dm³) were: 27.9±8.7 (Italy), 11.7±1.5 (Tyrrhenian Sea), 8.5±6.4 (Yangtze River), and 3.50 (Pearl River Delta). Relative standard deviations ranged from 31.6% to 140.3% for OCPs and 12.7% to 94.3% for PCBs, reflecting variability in data collection over time and across studies. In China and India, PCB levels showed a declining trend, remaining below 50 ng/dm³. Correlation analysis between individual OCPs and PCBs helped estimate emission timing into aquatic systems. Overall, while some regions show downward trends in ecotoxicant levels, PCB concentrations in natural waters remain relatively stable globally.