Monitoring cell adhesion by using thickness shear mode acoustic wave sensors

Li, Fang; Wang, James H.‐C.; Wang, Qing-Ming

doi:10.1016/j.bios.2007.03.018

Cited by 41 publications

(18 citation statements)

References 22 publications

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“…Although lots of sensors for DNA, enzyme and cells based on electrochemical [38] and QCM technique have been developed [39][40][41], however, to our knowledge, the process of mammalian cells adhering to CNTs filled biocomposite film has not been studied with the QCM.…”

Section: Introductionmentioning

confidence: 97%

Quartz crystal microbalance and electrochemical cytosensing on a chitosan/multiwalled carbon nanotubes/Au electrode

Jia

Tan

Xie

et al. 2008

Sensors and Actuators B: Chemical

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Section: Introductionmentioning

confidence: 97%

Quartz crystal microbalance and electrochemical cytosensing on a chitosan/multiwalled carbon nanotubes/Au electrode

Jia

Tan

Xie

et al. 2008

Sensors and Actuators B: Chemical

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“…In previous studies, we developed a multiple layer model for cells adhering to the thickness shear mode resonators [8,9]. Similarly, the cell-based Love mode biosensors can be considered to include four uniform layers, which are the semi-infinite piezoelectric substrate, wave-guiding layer, interfacial layer and semi-infinite cell layer.…”

Section: Theoretical Model and Simulationmentioning

confidence: 99%

Love mode surface acoustic wave sensors for cellular toxicity sensing

Qin

et al. 2014

2014 IEEE International Ultrasonics Symposium

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Clean water supply systems and infrastructure require periodic testing of water samples to maintain water quality. To enable this, toxicity tests need to be rapid, accurate, portable , and low cost to provide affordable water security especially in developing countries. Qualitative and quantitative measurement of contaminants in water is classically done by standard analytic chemical methods, which are time-consuming, labor-intensive, expensive, and cannot be performed easily outside the laboratory. An alternative to these methods is cell-based sensors, which can detect the presence of a wide range of toxicants by monitoring the cell states. Although electric cell-substrate impedance sensing (ECIS) has been demonstrated to be an effective method for water toxicity sensing, the use of ECIS only is not sensitive enough to detect many toxicants at low concentrations. Merging a sensor platform with multiparametric measurement capabilities could increase the security of detection. Love mode surface acoustic wave (SAW) device is considered as one of the powerful candidates for cell-based toxicity biosensors. In this study, a hybrid Love mode SAW/ECIS sensor was developed. Theoretical analysis and experiments were performed to demonstrate the capability of two sensing techniques (i.e., SAW and ECIS) for toxicity sensing.

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“…An understanding of the physics of the propagation process is of considerable importance because the TSM has been increasingly employed in bioanalytical chemistry in recent years with applications in the detection of nucleic acid duplex formation (Cavic and Thompson 2002), immunochemistry (Yang et al 1993), examination of protein conformational changes (Luppa, Sokoll, and Chan 2001), and study of the behavior of cells (Zhou et al 2000;Marx et al 2007;Gryte, Ward, and Hu 1993;Li et al 2007;Alessandrini et al 2006;Cheran et al 2008;Wang et al 2008). The theoretical aspects of the interaction of acoustic waves with such biochemical layers have been addressed and reviewed recently (Ellis 2008).…”

Section: Introductionmentioning

confidence: 98%

Modulation of Acoustic Coupling by Photo-Oxidation of Self-Assembled Monolayers

et al. 2010

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A thickness-shear mode acoustic wave device operated in a flow-injection configuration has been used to study the effects of oxygen on thiol-based self-assembled monolayers at the liquid-sensor interface when exposed to UV light. The films were composed of dodecanethiol or undec-5-yne-1-thiol. Piezoelectric AT-cut quartz sensors with gold electrodes were submerged in thiol solutions with varying amounts of oxygen present in the solution by altering the amount of time that the solutions were exposed to nitrogen. Oxygen was also removed or incorporated into the system by sparging the liquid buffer used in the flow system with helium gas. When exposed to UV radiation, the device with thiol monolayers in place exhibited reversible changes in series renounces frequency and motional resistance only in the presence of oxygen. This result is ascribed to a photochemically induced oxidation of the sulfur moiety at the device-liquid interface. The response of the device under these conditions is governed by acoustic coupling phenomena and not mass effects. Finally, the in situ cross-linking of undec-5-yne-thiol does not result in any additional changes in response other than those indicated for dodecanethiol confirming that thickness viscoelastic changes at the monolayer level are not relevant to device response.

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Monitoring cell adhesion by using thickness shear mode acoustic wave sensors

Cited by 41 publications

References 22 publications

Quartz crystal microbalance and electrochemical cytosensing on a chitosan/multiwalled carbon nanotubes/Au electrode

Quartz crystal microbalance and electrochemical cytosensing on a chitosan/multiwalled carbon nanotubes/Au electrode

Love mode surface acoustic wave sensors for cellular toxicity sensing

Modulation of Acoustic Coupling by Photo-Oxidation of Self-Assembled Monolayers

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