A study was conducted in Thuma area in central Malawi to quantify contemporary land cover and to explore the degree of land use change in the Thuma forest reserve area of Malawi by analysing and comparing satellite-derived land cover maps from 1997, 2007 and 2017. The study was carried out using Remote Sensing and Geographic Information System (GIS), focusing on analysis of Landsat 5 ETM and Landsat 8 ORI/TIRS satellite images. The classification was conducted for the following distinct classes; closed forest, open forest, shrubland, savanna grassland, agriculture fields, and water. The analysis revealed that closed forest diminished from 19% in 1997 to 10% in 2007 to 6% in 2017. Open forest reduced from 30% to 21% from 1997 to 2007 but increased to 22% in 2017. Agriculture area almost doubled from 37 % in 1997 to 64 % in 2017. Actual area from 1997 to 2017, shows that closed forest has reduced from 7,000 ha to 3,000 ha while open forest from 12,900 ha to 7800 ha. Savanna grassland has doubled from 5,900 ha to 13,000 ha. However, future studies should use modern satellites such as Sentinel and Landsat 9 for improved quantification of changes. The findings show that even the protected forest reserve (previously dominated by closed forest) is not fully protected from deforestation by local communities. Government and other stakeholders should devise measures to meet the needs of the surrounding communities and the ecological/biophysical needs of the reserves. Based on this study, issues of re-demarcation of the forest reserve and accessed area should also be explored. This study serves as a reference for the management of Thuma Forest Reserve as a refuge for natural tree species, rivers that harbour endemic fish species (Opsaridium microlepis and Opsaridium microcephalis) and the sustainable management of endangered elephants in the reserve.