2019
DOI: 10.1101/605444
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Monitoring contractility in single cardiomyocytes and whole hearts with bio-integrated microlasers

Abstract: 12Cardiac regeneration and stem cell therapies depend critically on the ability to locally resolve the 13 contractile properties of heart tissue 1,2 . Current regeneration approaches explore the growth of 14 cardiac tissue in vitro and the injection of stem cell-derived cardiomyocytes 3-6 (CMs) but scientists 15 struggle with low engraftment rates and marginal mechanical improvements, leaving the estimated 16 26 million patients suffering from heart failure worldwide without effective therapy 7-9 . One 17 impe… Show more

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Cited by 4 publications
(4 citation statements)
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“…The research data underpinning this publication can be accessed at https://doi.org/10.17630/97927f1f-a111-46d0-8d41-038771733b73. 49…”
Section: Competing Interestsmentioning
confidence: 99%
See 1 more Smart Citation
“…The research data underpinning this publication can be accessed at https://doi.org/10.17630/97927f1f-a111-46d0-8d41-038771733b73. 49…”
Section: Competing Interestsmentioning
confidence: 99%
“…The custom-made computer code is available at https://doi.org/10.17630/97927f1f-a111-46d0-8d41-038771733b73. 49 47.…”
Section: Competing Interestsmentioning
confidence: 99%
“…In the same vein, Wispering Galery Mode Microlasers are micron-sized deformable optical microresonators able to emit laser light pulses with a frequency dependent on their geometry 154 , and thus enabling the quantification of their deformation from their emission spectrum. These reporters have been inserted into the cytoplasm of contractile cardiomyocytes and in zebrafish hearts to monitor cell and organ contractility 155 , but they remain to be used as direct force reporters.…”
Section: Inclusionsmentioning
confidence: 99%
“…In the same vein, Whispering Gallery Mode Microlasers are micron-sized deformable optical microresonators able to emit laser light pulses with a frequency dependent on their geometry [177], and thus enabling the quantification of their deformation from their emission spectrum. These reporters have been inserted into the cytoplasm of contractile cardiomyocytes and in zebrafish hearts to monitor cell and organ contractility [178], but they remain to be used as direct force reporters.…”
Section: Inclusionsmentioning
confidence: 99%