Monitoring Local Disposition Kinetics of Carboplatinin Vivoafter Subcutaneous Injection in Rats by Means of195Pt NMR

Becker, Markus; Port, Ruediger E.; Zabel, H.-J.; Zeller, W. J.; Bachert, Peter

doi:10.1006/jmre.1998.1436

Cited by 18 publications

(6 citation statements)

References 26 publications

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“…49,50 A recent study involving the monitoring of local disposition kinetics of carboplatin after subcutaneous injection in rats was studied using 195 Pt NMR. 156 The in vitro measurements were performed in different solvents containing potassium tetrachloroplatinate(II), carboplatin and cisplatin which showed resonances at 21623, 21705 and 22060 ppm, respectively. The T 1 relaxation time of carboplatin was found to be around 100 ms.…”

Section: Pharmaceutical Chemistry (Drug Binding Studies)mentioning

confidence: 99%

195Pt NMR—theory and application

et al. 2007

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This critical review highlights the progress in (195)Pt NMR over the last 25 years. In particular, some of the recent applications of (195)Pt NMR in catalytic and mechanistic studies, intermetallics and drug binding studies are discussed. (195)Pt NMR chemical shifts obtained from both theoretical studies and experiments are presented for Pt(0), Pt(II), Pt(III) and Pt(IV) complexes. (195)Pt coupling with various nuclei (viz. coupling constants) have also been collected in addition to data on (195)Pt relaxation. The latest developments in the theoretical knowledge and experimental advances have made (195)Pt NMR into a rich source of information in many fields. (164 references.).

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Section: Pharmaceutical Chemistry (Drug Binding Studies)mentioning

confidence: 99%

195Pt NMR—theory and application

et al. 2007

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“…anti-cancer drug carboplatin 17 was selected as a candidate due to the likely complementarity between the size and shape of the drug and the confines of the molecular capsule. A 2 : 1 solution of carboplatin: p-phosphonic acid calix [5]arene in D 2 O was stirred within this inclined rotating tube at 1500 rpm under ambient conditions for five minutes.…”

Section: Communicationmentioning

confidence: 99%

Multifunctional water-soluble molecular capsules based on p-phosphonic acid calix[5]arene

et al. 2011

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“…However, the 195 Pt NMR has proved to be a helpful probe in investigating the biological activity of platinum-based drugs. For example, a recent study involving the monitoring of carboplatin after subcutaneous injection in rats was studied using 195 Pt NMR [ 34 ]. Thus, all the complexes presented here were characterized with standard techniques and the influence of structural variations, i.e., on one hand the coordination sphere and on the other hand the NHC ligand’s functionalization, were correlated to their chemical shift in 195 Pt NMR.…”

Section: Discussionmentioning

confidence: 99%

N-Heterocyclic Carbene Platinum(IV) as Metallodrug Candidates: Synthesis and 195Pt NMR Chemical Shift Trend

et al. 2020

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A series of octahedral platinum(IV) complexes functionalized with both N-heterocyclic carbene (NHC) ligands were synthesized according to a straightforward procedure and characterized. The coordination sphere around the metal was varied, investigating the influence of the substituted NHC and the amine ligand in trans position to the NHC. The influence of those structural variations on the chemical shift of the platinum center were evaluated by 195Pt NMR. This spectroscopy provided more insights on the impact of the structural changes on the electronic density at the platinum center. Investigation of the in vitro cytotoxicities of representative complexes were carried on three cancer cell lines and showed IC50 values down to the low micromolar range that compare favorably with the benchmark cisplatin or their platinum(II) counterparts bearing NHC ligands.

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Monitoring Local Disposition Kinetics of Carboplatinin Vivoafter Subcutaneous Injection in Rats by Means of195Pt NMR

Cited by 18 publications

References 26 publications

195Pt NMR—theory and application

195Pt NMR—theory and application

Multifunctional water-soluble molecular capsules based on p-phosphonic acid calix[5]arene

N-Heterocyclic Carbene Platinum(IV) as Metallodrug Candidates: Synthesis and 195Pt NMR Chemical Shift Trend

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