Monitoring magnesium degradation using microdialysis and fabric-based biosensors

Abstract

ABSTRACTindicating a high selectivity of the fabric device. Furthermore, the device requires only 3 µL of fluid sample to complete the measurement compared to spectroscopic method (±50 µL), hence providing a higher temporal resolution and reduced sampling time. The system could potentially provide a real time assessment of the degradation behavior, a new studied aspect in biodegradable metals research.

In-Vivo Corrosion Characterization and Assessment of Absorbable Metal Implants

“…It was suspected that the generated hydrogen bubbles inhibited sufficient distribution of the released elements in the circulating solution within the capillary, possibly leading to inaccurate results. Natasha et al [83] developed an online monitoring system which consisted of a microdialysis probe (to collect the fluid surrounding the Mg implant) and a fabric-based electrochemical device (FED) (as a catalytic Mg biosensor), both of which were connected to a potentiostat (Figure 8b). The set-up indicated a pseudo-linear response of concentration with ion selectivity as high as 99% and high temporal resolution with little sampling time and volume of the fluid sample as low as 3 µL.…”

“…Experimental setup of: (a) micro-flow-capillary-coupled Inductively Coupled Plasma Mass Spectrometer (ICP-MS); (b) coupled microdialysis probe-fabric-based electrochemical device (FED) biosensor connected to a potentiostat (inset: dialysate is dropped at the reaction region of the biosensor that was immobilized with the GK and GPOx enzymes to detect Mg 2+ ions via enzymes cascade reaction). Adapted with permission from Elsevier and Springer Nature[82,83].…”

Updates on the research and development of absorbable metals for biomedical applications

“…With this set-up, they analyzed the in situ and real-time electrochemical corrosion mechanism of magnesium alloy under the influence of dynamic flow as previously described. Lately, Natasha et al ( 2018 ) developed an online monitoring system which consisted of a microdialysis probe (as a tool to sample the fluid adjacent to magnesium implant) and a fabric-based electrochemical device (FED) (as a catalytic biosensor specific to Mg 2+ ), both of which were connected to a potentiostat (Fig. 6 b).…”

“…6 Corrosion monitoring systems: a experimental set-up of in situ and real-time flow-induced electrochemical corrosion study, b experimental set-up of the microdialysis probe-FED biosensor coupling with potentiostat (inset: dialyzate is dropped at the reaction zone of the FED that was immobilized with the GK and GPOx enzymes to detect Mg 2+ ions via enzymes cascade reaction), c hydrogen microsensor assembled on a micromanipulator for measuring hydrogen transdermally from a magnesium alloy implanted subcutaneously in a mouse where the sensor tip is in a direct contact with the mouse skin, d photograph of an anaesthetized nude mouse with marked measurement points, and color development of thin-film visual hydrogen sensor at two different observation times, e 3D reconstruction of the brightness change in the hydrogen sensor area at 213 min and associated volume change of the magnesium implant. Adapted with permission from Elsevier and Springer Nature (Wang et al 2016b ; Zhao et al 2016b , c ; Natasha et al 2018 ) …”

“… Adapted with permission from Elsevier and Springer Nature (Wang et al 2016b ; Zhao et al 2016b , c ; Natasha et al 2018 ) …”