Monitoring metastatic lesions in TENIS, initiating multi-targeted tyrosine kinase inhibitors and follow-up: should the newer FDG PET-CT quantitative indices be the defining objective parameter in clinical trials?

Basu, Sandip; Kalshetty, Ashwini

doi:10.1007/s00259-017-3648-x

Cited by 3 publications

(3 citation statements)

References 5 publications

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“… 24 They additionally serve as objective tools of assessment while monitoring the lesions. 25 In the setting of elevated Tg but negative radioiodine scan; FDG PET-CT can give additional information on tumor burden. It was found that those who achieved good reduction in Tg levels on suppressive hormonal therapy and with negative FDG PET-CT had good outcome, showing high negative predictive value of FDG PET-CT. 26 …”

Section: Discussionmentioning

confidence: 99%

Assessment of Pulmonary Metastasis in Differentiated Thyroid Carcinoma: Value of HRCT Correlation with Functional Imaging

Kalshetty

Basu

2023

World J Nucl Med

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Pulmonary metastases in thyroid carcinoma demonstrates varying imaging characteristics and disease biology and the outcome. The valuable complimentary role of high-resolution CT (HRCT) in conjunction with functional imaging such as radioiodine scan has been discussed and illustrated in this review along with the varied clinical and imaging presentations of lung metastases from differentiated thyroid cancer (DTC). A multi-modality patient-specific diagnostic approach and awareness about the atypical presentations helps in early identification as well as effective management of these patients, and especially in certain situations that could need multi-disciplinary management. While HRCT of the lungs as an added tool provides detailed visualization of the lung parenchyma, in the era of hybrid imaging, the routine adoption of SPECT-CT in patients with pulmonary metastases (in diagnostic or post-treatment settings) could provide equivalent or even incremental information from further management viewpoint.

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Section: Discussionmentioning

confidence: 99%

Assessment of Pulmonary Metastasis in Differentiated Thyroid Carcinoma: Value of HRCT Correlation with Functional Imaging

Kalshetty

Basu

2023

World J Nucl Med

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“…In the post-operative follow-up scenario, 18 F-FDG PET/CT can be used to identify lesions in patients in whom there is a suspicion of non-iodine-avid metastatic disease (based on elevated basal and/or stimulated Tg and negative radioiodine scan, i.e., Tg+/scan), classically termed as 'TENIS'. Figure 7 shows a TENIS patient exemplified with temporal profile of FDG-PET/CT [92] Following systemic therapies (such as tyrosine kinase inhibitors in TENIS), FDG-PET/CT is used routinely for treatment response and disease status evaluation. The 18 F-FDG-PET/CT metabolic parameters (e.g., standardized uptake value (SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG)) can be of potential help in defining the biology of the metastatic tumor burden, especially in patients with less favorable or non-response settings ("radioiodine refractory" thyroid cancer) [14,93].…”

Section: Role Of Fdg-pet/ctmentioning

confidence: 99%

“…While the bone metastasis is not a criterion in the standard RECIST criteria, the progressive disease was clearly evident in increasing indices on FDG-PET (arrowheadss) and osteolysis on CT (arrows). Reproduced with permission from:[92] 2017, Springer-Verlag Berlin Heidelberg.…”

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confidence: 99%

Comprehensive Review of the Imaging Recommendations for Diagnosis, Staging, and Management of Thyroid Carcinoma

Chakrabarty,

Mahajan,

Basu

et al. 2024

JCM

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Thyroid cancer is the most common head and neck cancer (HNC) in the world. In this article, we comprehensively cover baseline, posttreatment, and follow-up imaging recommendations for thyroid carcinomas along with the eighth edition of the tumor, node, metastasis (TNM) staging system proposed by the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC). We include characterization and risk stratification of thyroid nodules on ultrasound (US) proposed by various international bodies. Management guidelines (depending upon the type of thyroid carcinoma) based on the international consensus recommendations (mainly by the American Thyroid Association) are also extensively covered in this article, including the role of a radioiodine scan. The management of recurrent disease is also briefly elucidated in this article. In addition, we cover the risk factors and etiopathogenesis of thyroid carcinoma along with the non-imaging diagnostic workup essential for thyroid carcinoma management, including the significance of genetic mutations. US is the diagnostic imaging modality of choice, with US-guided fine needle aspiration (FNA) being the procedure of choice for tissue diagnosis. The roles of computed tomography (CT), magnetic resonance imaging (MRI), and fluorodeoxyglucose positron emission tomography/CT (FDG-PET/CT) in thyroid carcinoma staging are also specified. Through this article, we aim to provide a comprehensive reference guide for the radiologists and the clinicians in the pursuit of optimal care for patients with thyroid carcinoma.

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Sub-segmentation specific paradigms for better individualized management of poorly differentiated thyroid carcinoma: can a systematic approach be evolved?

Basu

Kalshetty

2020

Nuclear Medicine Communications

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Monitoring metastatic lesions in TENIS, initiating multi-targeted tyrosine kinase inhibitors and follow-up: should the newer FDG PET-CT quantitative indices be the defining objective parameter in clinical trials?

Cited by 3 publications

References 5 publications

Assessment of Pulmonary Metastasis in Differentiated Thyroid Carcinoma: Value of HRCT Correlation with Functional Imaging

Assessment of Pulmonary Metastasis in Differentiated Thyroid Carcinoma: Value of HRCT Correlation with Functional Imaging

Comprehensive Review of the Imaging Recommendations for Diagnosis, Staging, and Management of Thyroid Carcinoma

Sub-segmentation specific paradigms for better individualized management of poorly differentiated thyroid carcinoma: can a systematic approach be evolved?

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