Monitoring of adverse drug reactions in psychiatry outpatient department of a Secondary Care Hospital of Ras Al Khaimah, UAE

Sridhar, Sathvik Belagodu; Al-Thamer, Sura Saad Faris; Jabbar, Riadh

doi:10.4103/0976-0105.183263

Cited by 29 publications

(61 citation statements)

References 28 publications

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“…8,[13][14][15][16] The present study also shows similar results. Most of the ADRs were mild in nature on the severity scale.…”

Section: Discussionsupporting

confidence: 79%

“…13,16 More than 50% ADRs were seen in the age group of 21-40 yrs, which is working and productive; also correlates well with previous studies. 8,13,16 Some reasons could be prevalence of the disorder or better treatment seeking practices among the working age group or more attention to their health. The most commonly diagnosed condition was schizophrenia and related disorders, closely followed by mood disorders.…”

Section: Discussionmentioning

confidence: 99%

“…ADR monitoring helps to develop appropriate interventional strategies to manage, prevent and minimize the risk of developing ADRs and thereby increasing the quality of life and reducing the cost of care. 8 Data regarding ADRs due to psychotropic medication and their patterns in patients with psychiatric disorders is scanty. This study was therefore planned to monitor and assess the ADRs at the psychiatry outpatient department (OPD) of a tertiary care hospital.…”

Section: Introductionmentioning

confidence: 99%

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Adverse drug reaction profile at psychiatry outpatient department of a tertiary care centre

Gawali

Kesari

Gawand

2017

Int J Basic Clin Pharmacol

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Background: Monitoring adverse drug reactions (ADRs) helps in alerting physicians and developing strategies to prevent and minimize the risk of developing ADRs. Data regarding pattern of ADRs due to psychotropic medications is scanty. Hence, the study was planned to assess ADRs among psychiatry outpatients of a tertiary care hospital in Maharashtra.Methods: A prospective, observational study was conducted in psychiatry outpatient department of a tertiary care centre for 3 months. Cases were enrolled by active and passive surveillance after obtaining informed consent. Demographic details, adverse event details, history of medications were recorded. Pattern of ADRs was studied according to demographic parameters, drug class, organ system affected, causality (WHO - Uppsala Monitoring Centre Scale) and severity (modified Hartwig and Siegel Scale).Results: Out of total 1200 patients screened, 77 qualified the inclusion and exclusion criteria and 92 ADRs were reported; overall incidence rate of 6.41%. Maximum ADRs were reported in the age group of 31- 40 years. 63.63% subjects received more than 2 psychotropic drugs. Among 24 types of ADRs observed, tremor (13.04%) was the commonest, closely followed by somnolence. Antipsychotics (45.65%) were most frequently incriminated and central nervous system (46.73%) the most often affected. Trifluoperazine (11.96%) was the commonest drug, followed by olanzapine and haloperidol (10.53% each). Causality analysis yielded 66 ADRs as “probable” and on severity analysis 80.43% were mild.Conclusions: The study provides an insight into pattern of ADRs in psychiatry outpatients. It is prudent to communicate this to treating physicians as well as counsel patients (and caregivers). Initiatives and concerted efforts involving all stakeholders in healthcare can go a long way in decreasing drug-related morbidity and health costs.

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“…8,[13][14][15][16] The present study also shows similar results. Most of the ADRs were mild in nature on the severity scale.…”

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Adverse drug reaction profile at psychiatry outpatient department of a tertiary care centre

Gawali

Kesari

Gawand

2017

Int J Basic Clin Pharmacol

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“…1 ADR monitoring in psychiatry unit play an important role in detecting the patients at high risk for developing ADRs and to understand the nature of ADRs in a local population which helps to alert the physicians about the possibility of such events thereby protecting the patients from avoidable harm. 2,3 ADRs associated with psychotropic drugs causes either noncompliance or at times discontinuation of therapy. 4 The incidence of serious and fatal ADRs in out-patient setting ranges from 5% to 35%.…”

Section: Introductionmentioning

confidence: 99%

“…8 ADR monitoring helps in developing appropriate interventional strategies to manage, prevent and minimize the risk of developing ADRs and thereby reducing the cost of care. 2 The study of ADRs is the field known as pharmacovigilance. 7 Pharmacovigilance is the pharmacological science relating to the detection, assessment, understanding and prevention of adverse effect, particularly long term and short term side effects of medicines.…”

Section: Introductionmentioning

confidence: 99%

Pharmacovigilance study in psychiatry out-patient department of a tertiary care teaching hospital

Ramarao

2017

Int J Basic Clin Pharmacol

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Background: Adverse drug reactions are important in psychiatry practice like any other branch of medicine. Adverse drug reactions associated with psychotropic drugs causes either noncompliance or at times discontinuation of therapy. The objective of the study was to evaluate the incidence and nature of adverse drug reactions in psychiatry outpatient department and to assess the causality and severity of the documented adverse drug reactions. Methods: Prospective observational study was done in the psychiatry outpatient department. All the patients were interviewed for basic details, history of medications and relevant history for adverse drug reactions. The causality, severity and modes of management assessment of the documented adverse drug reactions were done. Results: 2,727 patients attended psychiatry outpatient department, of which 582 patients developed at least one adverse drug reaction. The incidence of adverse drug reaction observed to psychotropic drugs was 21.34%. Majority of adverse drug reactions were seen with antidepressants 298 (10.93%) followed by antipsychotics 187 (6.86%), sedative hypnotics, anticonvulsants and antimanics. The most common adverse drug reactions were sedation 3.44%, weight gain 3.04%, and extrapyramidal symptoms 2.79%. Reported adverse drug reactions were assessed for causality and maximum belonged to probable (15.6 9%). The severity assessment of the reported adverse drug reactions revealed that most of the adverse drug reactions were mild (16.83%) in nature and majority of patients were made to continue the same treatment. Conclusions: Active monitoring of adverse drug reactions in psychiatry outpatient department can help in early detection and management of adverse drug reactions.

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Overview of pharmacovigilance practices at the largest academic healthcare system in the State of Qatar

et al. 2018

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Adverse Drug Reactions (ADRs) are major global concern, adversely impacting patient safety and health outcomes. ADRs cause significant morbidity and mortality among hospitalised patients, causing greater length of hospital stay, increased healthcare costs and patient dissatisfaction to the treatments. Pharmacovigilance (PV), a process of detecting, monitoring and preventing drug-related harm, plays a vital role to ensure patient safety. ADR reporting is the cornerstone of PV. PV practices in Qatar are relatively new and are evolving rapidly. The purpose of this article is to explore the medication safety practices (notably ADR reporting) at the largest academic healthcare center in Qatar. The article further provides evidence on how information related to ADRs are generated and interpreted. Furthermore, it describes how a designated center for monitoring medication safety activities was established at the largest healthcare provider in Qatar.

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Monitoring of adverse drug reactions in psychiatry outpatient department of a Secondary Care Hospital of Ras Al Khaimah, UAE

Cited by 29 publications

References 28 publications

Adverse drug reaction profile at psychiatry outpatient department of a tertiary care centre

Adverse drug reaction profile at psychiatry outpatient department of a tertiary care centre

Pharmacovigilance study in psychiatry out-patient department of a tertiary care teaching hospital

Overview of pharmacovigilance practices at the largest academic healthcare system in the State of Qatar

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