Monitoring of Adverse Reactions to Penicillins in Patients of Healthcare Institutions in the City of Kharkiv and Kharkiv Region

Abstract

Aim. The paper aims at analyzing the state of monitoring of adverse reactions to penicillins based on spontaneous reports of the pharmacovigilance system of Ukraine, received from healthcare institutions of Kharkiv region and the city of Kharkiv during 2017-2019.
 Materials and Methods. The objects of the study included maps-reports of adverse reactions to the use of penicillins, which came from health care facilities of Kharkiv region and the city of Kharkiv to the pharmacovigilance system of Ukraine during 2017-2019. Information on adverse drug reactions was obtained using the method of collecting spontaneous messages in mixed form (paper and electronic versions).
 Results. The analysis revealed that among the 6 INNs of the penicillin group, the largest number of adverse reactions were registered for amoxicillin / clavulanic acid (in 2017 - 73% of message cards, in 2018 - 54% of message cards, in 2019 - 70% of message cards). In the number of reports amoxicillin drugs ranked second place (in 2017 - 22% of card-messages, in 2018 - 43% of card-messages, in 2019 - 27% of card-messages).
 Discussion. The recorded adverse reactions are not serious and most frequently manifested in the form of local reactions: itching, swelling and redness of the skin, as well as from the gastrointestinal tract: diarrhea and nausea. No serious adverse reactions with lethal outcome were reported.
 Conclusions. The conducted monitoring confirmed the literature data on typical adverse reactions to antibiotics of the penicillin group. It has been established that penicillin-type antibiotics, namely amoxicillin/clavulanic acid and amoxicillin, have a high risk of adverse reactions as they are prescribed more frequently.