Monitoring of antimicrobial susceptibility of Streptococcus suis in the Netherlands, 2013–2015

Hout, Jobke van; Heuvelink, Annet; Gonggrijp, Maaike

doi:10.1016/j.vetmic.2016.03.014

Cited by 44 publications

(43 citation statements)

References 21 publications

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“…However, a Chinese report showed relatively lower susceptibility (77.9%) of S. suis isolates to ceftiofur compared with that detected in the present study [44]. The MIC 50 (≤0.032 µ g/m l ) and MIC 90 (0.5 µ g/m l ) values for ampicillin obtained in the present study were higher than those reported for isolates in the Netherlands (0.0125 µ g/m l and 0.1 µ g/m l , respectively) [37], but were lower than those reported in China (0.2 µ g/m l and 2 µ g/m l , respectively) [44]. Overall, the present results suggest that β-lactam antimicrobials could be the best option for treating S. suis infection in Korea.…”

Section: Discussioncontrasting

confidence: 41%

“…However, most of the S. suis isolates in Belgium and the Netherlands tended to be highly susceptible to enrofloxacin [3, 37, 45]. This geographical discrepancy may be attributed to the extent to which enrofloxacin is used for the clinical treatment of diseased pigs in different regions [38].…”

Section: Discussionmentioning

confidence: 99%

“…In the absence of effective vaccines to prevent S. suis , antimicrobials, such as broad-spectrum penicillins, have been traditionally used to treat pigs with clinical signs of S. suis infection [37]. However, previous studies have warned about the routine treatment of S. suis with penicillin, and high rates of resistance to other commonly used antimicrobials in the swine industry have been reported [1, 13].…”

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confidence: 99%

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Capsular serotypes, virulence-associated genes and antimicrobial susceptibility of <i>Streptococcus suis</i> isolates from pigs in Korea

Jeon

Jung

et al. 2017

The Journal of Veterinary Medical Science

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Streptococcus suis is an important pig pathogen with potential for human transmission. The serotype distributions and phenotypic characteristics vary over time and among regions; however, little is known about the characteristics of S. suis isolates in Korea. In this study, 240 S. suis isolates collected from pigs in Korea in 2009–2010 were serotyped by coagglutination tests, subsequently screened for three virulence-associated genes (mrp, epf and sly) and tested for antimicrobial susceptibility. As for 80 isolates, the serotypes of which were relevant to human infections, clonal complexes (CCs) were further identified by PCR. Serotype 3 was the most prevalent (15.8%), followed by serotype 2 (15.0%), with geographical variation for each serotype. Overall, 55.4% of the isolates carried mrp, whereas only 3.8% carried epf. CC25 was the most prevalent (41.3%) and was related to serotypes 2 and 9. The isolates showed higher susceptibility to ampicillin (93.4%) and ceftiofur (90.8%) than to the other antimicrobial agents tested. The highest resistance rate was observed to tetracycline (98.0%), followed by erythromycin (88.8%). In addition, the resistance to certain antimicrobials was significantly associated, in part, with virulence-associated genes or serotypes. Therefore, continuous characterization of S. suis is essential for the benefit of veterinary and human medicine.

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Section: Discussioncontrasting

confidence: 41%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Capsular serotypes, virulence-associated genes and antimicrobial susceptibility of <i>Streptococcus suis</i> isolates from pigs in Korea

Jeon

Jung

et al. 2017

The Journal of Veterinary Medical Science

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“…Observations of calves that outlived this period, were censored at 200 days. The Kaplan-Meier survival function in Stata (Stel et al, 2011;Kaplan and Meier, 1958) was used to determine the daily hazard rate, conditional on having survived until that specific day. Parameters such as mortality rates, probability of survival and the cumulative probability of dying were presented using life tables.…”

Section: Statistical Analysesmentioning

confidence: 99%

Using routinely collected data to evaluate risk factors for mortality of veal calves

Santman-Berends

Bont-Smolenaars

Roos

et al. 2018

Preventive Veterinary Medicine

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From 2009 to 2012 a gradual increase in on-farm mortality of Dutch veal calves was observed. In 2012, the cattle industry decided that more information was needed on risk factors for mortality in both veal herds and herds of origin to enable implementation of risk mitigating measures. Routinely collected data were available from seven different data sources and contained information from 2.4 million white veal calves that were fattened in the period between 1 January 2011 and 30 June 2014. Survival analysis techniques (Kaplan-Meier), multilevel Poisson and multilevel Logistic regression models were applied to analyse the data. Two different models were assembled in which risk factors for veal calf mortality in respectively veal herds and herds of origin were identified. Univariable and multivariable regression techniques were used to detect risk factors significantly associated with mortality of veal calves during the fattening period. During the study period, the mean mortality was 4.9% per production cycle. The probability to die was highest during the first weeks after arrival in the veal herds and declined thereafter. Important risk factors included a veal herds with a higher use of antimicrobials, hair colour as proxy for breed, certain countries of origin, veal herd management with a limited amount of supplied feed and a not having an all-in / all-out system. A higher body weight at arrival in the veal herd was associated with lower mortality as well as veal calves that were fed an above median amount of milk, roughage and concentrates. From the calves that were fattened during the study period, observations of 1.1 million calves originated from the Netherlands and were available to study risk factors for veal calf mortality associated with the herd of origin. Important risk factors included purchase, herds with high mortality rates in the quarter in which the calf was born, fast growth in herd size, high cattle replacement rates and a higher antibiotic use in the quarter of birth. Calves that originated from herds that were certified BVD-free, Salmonella-unsuspected or Paratuberculosis-unsuspected, had a lower odds to die during the subsequent fattening period in a veal herd. Veal calf mortality was influenced by risk factors at the herd of origin as well as at veal herds. Adequate collaboration between the different industries is necessary to optimize veal calf management leading to a reduction in veal calf mortality during the fattening period.

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“…Antimicrobial agents play an important role in the treatment and control of S. suis infection. However, irrational use of antibiotics leads to a continual increase in drug resistance of S. suis worldwide [11][12][13][14][15] . Therefore, antimicrobial susceptibility testing is a crucial step preceding the prescription of antibiotic treatment.…”

Section: Introductionmentioning

confidence: 99%

Güney Çin’de Hastalıklı ve Sağlıklı Domuzlarda Streptococcus suis’in Antimikrobiyal Direnci, Serotipleri ve Genetik Çeşitliliği

Peng¹,

ChongBo²,

Yang³

et al. 2019

Kafkas Univ Vet Fak Derg

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In the study, the characteristics of 81 Streptococcus suis isolates recovered from healthy and diseased pigs in Southern China were analyzed. These isolates showed differential resistance rates of over 40% to 22 and over 80% to 11 antibiotics out of 42 tested drugs. These isolates belonged to 6 serotypes (2, 3, 7, 9, 19, and 28), 9.9% of which were characterised as non-typable (NT), and were classified into 15 sequence types (STs), 8 of which were new (ST812-ST815, ST821-823, and ST832). Additionally, 6 virulence-associated gene patterns (VAGPs) and 10 random amplified polymorphic DNA (RAPD) patterns were found among the 81 strains. Among the 4 genotyping methods used in this study, multilocus sequence typing (MLST) provided the highest resolution for identification of S. suis strains. Significant differences in STs, RAPD patterns, and VAGPs were observed between strains isolated from healthy pigs and those isolated from diseased pigs. This study did not find any statistically significant correlations between antimicrobial resistance and serotypes, STs, RAPD patterns, VAGPs, or strain sources. Serotype 2 strains were predominant (44.4%) in the study and all of these strains showed the molecular characteristics of highly pathogenic strains in VAGP, GDH sequence types, and MLST. Our results showed that S. suis strains in Southern China are continually evolving, and therefore increased surveillance of S. suis in piggeries must be considered. Güney Çin'de Hastalıklı ve Sağlıklı Domuzlarda Streptococcus suis'in Antimikrobiyal Direnci, Serotipleri ve Genetik Çeşitliliği ÖzBu çalışmada Güney Çin'de sağlıklı ve hasta domuzlardan elde edilen 81 Streptococcus suis izolatının özellikleri incelendi. İzolatlar, test edilen 42 antibiyotikten 22'sine %40'ın üzerinde ve 11'ine %80'in üzerinde değişen direnç gösterdi. Bu izolatlar 6 serotipe (2,3,7,9,19 ve 28) ait olup %9.9'u tiplendirilemeyen olarak karakterize edildi ve 8'i yeni (ST812-ST815, ST821-823 ve ST832) olmak üzere 15 sekans tipine (ST) sınıflandırıldı. Ayrıca, 81 suşta 6 adet virulans ile ilişkili gen şeması (VAGP) ve 10 adet rastgele amplifiye polimorfik DNA (RAPD) şeması bulundu. Çalışmada kullanılan 4 genotiplendirme metodu arasında multilokus sekans tiplendirme (MLST) S. suis suşlarının tespitinde en yüksek rezolusyonu sağladı. Sağlıklı ve hasta domuzlardan izole edilen suşlar arasında sekans tiplerinde, RAPD şemasında ve VAGP'lerde anlamlı farklılıklar gözlemlendi. Çalışmada antimikrobiyal direnç ile serotipler, ST, RAPD şeması, VAGP'ler veya suş kaynakları arasında istatistiksel olarak bir ilişki tespit edilmedi. Serotip 2 suşu çalışmadaki predominant olandı ve tüm bu suşlar VAGP, GDH sekans tipi ve MIST'de oldukça patojenik suşların moleküler özelliklerini göstermekteydi. Elde edilen sonuçlar Güney Çin'de S. suis suşlarının sürekli olarak değiştiğini ve bu yüzden domuzlarda S.suis takibinin gerekli olduğunu göstermiştir.

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Monitoring of antimicrobial susceptibility of Streptococcus suis in the Netherlands, 2013–2015

Cited by 44 publications

References 21 publications

Capsular serotypes, virulence-associated genes and antimicrobial susceptibility of <i>Streptococcus suis</i> isolates from pigs in Korea

Capsular serotypes, virulence-associated genes and antimicrobial susceptibility of <i>Streptococcus suis</i> isolates from pigs in Korea

Using routinely collected data to evaluate risk factors for mortality of veal calves

Güney Çin’de Hastalıklı ve Sağlıklı Domuzlarda Streptococcus suis’in Antimikrobiyal Direnci, Serotipleri ve Genetik Çeşitliliği

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