Monitoring of Asthma Outpatients After Adapting Treatment to Meet International Guidelines

Morell, Ferrán; Genover, Teresa; Reyes, Leonardo; Benaque, Esther; Roger, Albert; Ferrera, Jaume

doi:10.1016/s1579-2129(07)60017-2

Cited by 6 publications

(3 citation statements)

References 21 publications

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“…1 It is the most common chronic lung disease in both the developed and developing countries. 2 , 3 Multicenter studies conducted in large general populations indicate that asthma is a disease extremely prevalent with up to one out of ten adults and one out of three children worldwide. 4 , 5 Asthma is responsible for a significant personal and social burden, due to staggering costs to the patient and the health care system, and the potential for adverse outcomes.…”

Section: Introductionmentioning

confidence: 99%

The efficacy of nebulized magnesium sulfate alone and in combination with salbutamol in acute asthma

Sarhan

Ali

Youssef

2016

DDDT

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ObjectiveEvaluation of the efficacy of nebulized magnesium sulfate (MgSO4) alone and in combination with salbutamol in acute asthma.MethodsA double-blind randomized controlled study was conducted in Chest and Emergency Departments. Thirty patients of acute attack of bronchial asthma were randomized into three groups: MgSO4 nebulization (group A), salbutamol nebulization (group B), and their combination (group C). All patients were monitored before and after nebulization (each 20 minutes) for peak expiratory flow rate (PEFR), respiratory rate (RR), heart rate (HR), blood pressure, pulsus paradoxus, oxygen saturation, clinical examination, and Fischl index.ResultsA highly significant improvement in PEFR, PEFR percentage, and Fischl index and significant decrease in RR and HR was observed in all groups. A similar improvement in PEFR was observed in group A and group B (P=0.389). The difference in peak expiratory flow (PEF) improvement was insignificant between group B and group C (P=0.101), while there was a significant difference between group A and group C (P=0.014) in favor of group C.ConclusionNebulized MgSO4 alone or combined with salbutamol has a clinically significant bronchodilator effect in acute asthma and leads to clinical improvement, increase in PEFR, reduction in HR, and reduction in RR. The response to nebulized MgSO4 alone (PEFR improvement 54±35.6 L/min, P=0.001) is comparable (P=0.389) to that of nebulized salbutamol (PEFR improvement 67.0±41.9 L/min, P=0.001) and is significantly less than (P=0.014) that of nebulized combination (PEFR improvement 92.0±26.9 L/min, P=0.000).

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Section: Introductionmentioning

confidence: 99%

The efficacy of nebulized magnesium sulfate alone and in combination with salbutamol in acute asthma

Sarhan

Ali

Youssef

2016

DDDT

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“…The prevalence of childhood asthma varies from 10% to 30%. 1,2 Different studies show that asthma is prevalent up to one out of three children worldwide. 3,4 Intermittent acute exacerbations are common and are characterized by episodes of cough, respiratory distress, dyspnea, wheeze.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Nebulized Magnesium Sulphate in the Treatment of Acute Bronchial Asthma Compared to Nebulized Salbutamol: A Randomized Control Trial

Sarmin

Anwar

Khan

et al. 2020

Bangladesh J Child Health

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Background: Nebulized salbutamol is commonly used in treatment of asthma in children. The use of nebulized MgSO4 is one of the different treatment options available during acute exacerbation. Objective: To compare the efficacy of nebulized MgSO4 with nebulized salbutamol in the treatment of acute asthma in children. Materials and method: This randomized controlled study was conducted in Dhaka Medical College Hospital between January to December 2016. Children of 7-12 years with acute exacerbation of asthma were randomized into study group-A (MgSO4 group, n=30) and control group-B (Salbutamol group, n=30). Children of both groups were treated with serial nebulization thrice at 20 minute intervals by either 2.4 ml (4% MgSO4, 96 mg) or salbutamol (0.15 mg/kg minimum 2.5 mg) with 2.5 ml of isotonic normal saline. Results: The mean final PEFR were not different between the two groups (275.0±41.42 L/min in MgS04 group and 263±36.17 L/min in salbutamol group). The increase in PEF was statistically significant and comparable in both groups (by 35.1% in the MgS04 group and by 42.1% in the salbutamol group). Fischl score improvement was comparable and significant in both groups (4.31 to 0.43 in MgS04 group and 4.29 to 0.76 in salbutamol group). Statistically significant increase in oxygen saturation and reduction of heart rate was found in MgS04 group without any side effects. Nebulized MgSO4 was found having significant bronchodilator effect which is comparable to salbutamol. Conclusion: Nebulized MgS04 was found equally effective as nebulized salbutamol in the treatment of severe acute asthma in children. Bangladesh J Child Health 2020; VOL 44 (1) :24-29

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“…The prevalence of asthma in Iranian children is between 1.26–11.6%, depending on gender, race, and socioeconomic status ( 2 ). Insufficient asthma management could cause repeated emergency department visits by patients who are in asthma crisis ( 3 ). Exacerbation of acute bronchial asthma is a common medical emergency ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Severe angina pectoris in asthma attack: a case report

et al. 2016

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Asthma is a chronic inflammatory disorder of the airways related to the obstruction of reversible airflow. Asthma presents as recurrent attacks of cough and dyspnea. Poor control causes recurrent admissions to the ICU, and mortality is related to poor drug compliance and follow-up. Angina pectoris is a syndrome of recurrent chest discomfort related to myocardial ischemia. The presence of these two disorders rarely has been reported. We reported a 12-year-old boy who was referred with exacerbation of asthma and developed angina pectoris during hospitalization. He had labored breathing and diffuse wheezing. During treatment of the asthma, the patient developed severe chest pain due to shunt formation and coronary hypoxia, caused by the sole administration of ventolin, since oxygen had been disconnected. After receiving appropriate therapy, both his asthma and angina recovered, and, to date, he has not experienced angina pectoris again.

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Monitoring of Asthma Outpatients After Adapting Treatment to Meet International Guidelines

Cited by 6 publications

References 21 publications

The efficacy of nebulized magnesium sulfate alone and in combination with salbutamol in acute asthma

The efficacy of nebulized magnesium sulfate alone and in combination with salbutamol in acute asthma

Efficacy of Nebulized Magnesium Sulphate in the Treatment of Acute Bronchial Asthma Compared to Nebulized Salbutamol: A Randomized Control Trial

Severe angina pectoris in asthma attack: a case report

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